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Characterization of an H4N2 avian influenza virus isolated from domestic duck in Dongting Lake wetland in 2009

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Abstract

In January 2009, an H4N2 subtype of avian influenza virus [A/duck/Hunan/8-19/2009 (H4N2)] was isolated from domestic ducks in Dongting Lake wetland. The whole genome of the virus was sequenced and the results indicated that multiple gene segments of the virus had a high homology with viruses isolated from wild waterfowl, which indicated that the virus was probably transmitted from wild waterfowl to domestic ducks. Phylogenetic analysis revealed that the each gene belonged to the Eurasian lineage of avian influenza viruses, but genetic reassortment occurs between viruses of different subtypes.

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Acknowledgments

This study was supported by the following research funds: European Union Project (SSPE-CT-2006-44405); National 973 Project (2010CB530301); National Key Technology R&D Program of China (2006BAD06A03); National Natural Science Foundation of China.

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Authors and Affiliations

  1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430071, China

    Hongbo Zhang, Quanjiao Chen & Ze Chen

  2. College of Life Science, Hunan Normal University, Changsha, Hunan, 410081, China

    Ze Chen

  3. Shanghai Institute of Biological Products, Shanghai, 200052, China

    Ze Chen

  4. Graduate University of Chinese Academy of Sciences, Beijing, 100049, China

    Hongbo Zhang

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  1. Hongbo Zhang
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  2. Quanjiao Chen
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Correspondence to Ze Chen.

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Zhang, H., Chen, Q. & Chen, Z. Characterization of an H4N2 avian influenza virus isolated from domestic duck in Dongting Lake wetland in 2009. Virus Genes 44, 24–31 (2012). https://doi.org/10.1007/s11262-011-0658-9

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  • DOI: https://doi.org/10.1007/s11262-011-0658-9

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