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Accelerated evolution of PRRSV during recent outbreaks in China

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Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is reported to have evolved at a higher evolutionary rate than other RNA viruses. However, whether this virus is capable of evolutionary acceleration during outbreaks remains unknown. In this study, we analyze the data based on ORFs of eight newly obtained epidemic PRRSVs from Hebei province with other viral genomes from GenBank. Phylogenetic analysis suggested that all isolates during recent outbreaks (2006–2008) are grouped together. We also find that ORF5 genes of this viral group are positively selected, suggesting their higher evolutionary rates and coinciding with that period of large-scale outbreaks in China. The evolutionary rate of 3.29 × 10−3 substitutions per nucleotide site per year also suggests the higher evolutionary rate of these viruses. We concluded that PRRSVs isolated during 2006–2008 in China underwent accelerated evolution, and predicted that this accelerated evolution equip these viruses more adapted to their primary hosts.

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Acknowledgments

The authors sincerely thank Dr. Qingbiao Wang and Dr. Yang Zhong, Center for Evolutionary Biology, School of Life Sciences, Fudan University, for their technical supports; thank Dr. Peter Daszak for his helpful comment; thank the Bureau of Animal Husbandry and Veterinary Medieine of Shijiazhuang to afford the materials and approve the research; and also thank the National Research Center for Wildlife Born Diseases, Institute of Zoology, Chinese Academy of Sciences to collect the samples. This work was supported by Natural Science Foundation of Hebei Province (2007000263) to Baohua Zhao; and was supported by 2010 PhD Program Scholarship Fund of ECNU (2010044) to Jie Cui.

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Authors and Affiliations

  1. College of Life Sciences, Hebei Normal University, Shijiazhuang, 050016, China

    Jie Song, Di Shen, Jie Cui & Baohua Zhao

  2. School of Life Sciences, East China Normal University, Shanghai, 200062, China

    Jie Song, Di Shen, Jie Cui & Baohua Zhao

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  1. Jie Song
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  2. Di Shen
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  3. Jie Cui
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Correspondence to Jie Cui or Baohua Zhao.

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Jie Song and Di Shen contributed equally to this paper.

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Song, J., Shen, D., Cui, J. et al. Accelerated evolution of PRRSV during recent outbreaks in China. Virus Genes 41, 241–245 (2010). https://doi.org/10.1007/s11262-010-0507-2

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