Skip to main content

Advertisement

SpringerLink
Log in

A novel fish herpesvirus of Osmerus eperlanus

  • Published:
Virus Genes Aims and scope Submit manuscript

Abstract

A herpesvirus of smelt (Osmerus eperlanus) was identified by thin section electron microscopy. Degenerated cells of skin lesions located on the back fin of smelt showed either intranucleic- or cytoplasmic herpesvirus-specific structures. In the nuclei “naked” virus capsids with a diameter of about 100 nm were observed. The diameter of the complete virion including its unilaterally extended envelope ranged from 200 to 350 nm. Remarkably, in complete virions the electron-opaque tegument is completely filling the region between nucleocapsid and envelope and as another unique feature the virion shows a “comet-shape” due to a long unilateral extension of its envelope. This kind of shape had been not reported for any of herpesviruses known so far. Consequently this virus was termed herpesvirus of Osmerus eperlanus (HVOE1) or Comet herpesvirus of smelt. Due to the long time storage at the nonstandard temperature of smelt virus the biological and genomic analysis of the HVOE1 was hampered. All attempts to study host range of HVOE1 failed as no virus replication was observed, indicating that infectivity was lost or the suitable cell culture was missing. The genomic DNA of HVOE1 was analyzed by DNA restriction endonucleases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. S. Essbauer, W. Ahne, J Vet Med B 48, 403–475 (2001)

    Article  CAS  Google Scholar 

  2. A.J. Davison, R. Eberle, B. Ehlers, G.S. Hayward, D.J. McGeoch, A.C. Minson, P.E. Pellett, B. Roizman, M.J. Studdert, E. Thiry, Arch. Virol. 154, 171–177 (2009)

    Article  CAS  PubMed  Google Scholar 

  3. T.B. Waltzek, G.O. Kelley, M.E. Alfaro, T. Kurobe, A.J. Davison, R.P. Hedrick, Dis Aquat Org 84, 179–194 (2009)

    Article  CAS  PubMed  Google Scholar 

  4. F.P. Meyer, J. Anim. Sci. 69, 4201–4208 (1991)

    CAS  PubMed  Google Scholar 

  5. R.P. Hedrick, T. Sano, in Viruses of Lower Vertebrate, ed. by W. Ahne, E. Kurstak (Springer, Heidelberg, 1989), pp. 161–170

    Google Scholar 

  6. K. Anders, H. Möller, J. Fish Dis. 8, 233–235 (1985)

    Article  Google Scholar 

  7. K. Anders, Biology of Tumour- and Tumour-like Diseases of Fish from the Lower Elbe River (Moeller Publications, Kiel, 1988)

    Google Scholar 

  8. K. Anders, LCD of Fishes, in Viruses of Lower Vertebrates, ed. by W. Ahne, E. Kurstak (Springer-Verlag, Heidelberg, 1989), pp. 141–160

    Google Scholar 

  9. K. Anders, A Herpesvirus Associated with an Epizootic Epidermal Papillomatosis in European Smelt, Osmerus eperlanus L, in Viruses of Lower Vertebrates, ed. by W. Ahne, E. Kurstak (Springer-Verlag, Heidelberg, 1989), pp. 184–197

    Google Scholar 

  10. K. Anders, M. Yoshimizu, Dis Aquat Org 19, 215–232 (1994)

    Article  Google Scholar 

  11. H. Moller, Helgolaender Meeresunters 37, 389–413 (1984)

    Article  Google Scholar 

  12. C.N. Burke, R.L. Herman, S. Perry, Virus Infection of Squamous Cell Carcinoma in Rainbow Smelt (Osmerus mordax). Proceedings of the 14th Annual Eastern Fish Health 80 Workshop, 17–20 July, Annapolis, USA, 1989, p. 15

  13. R.L. Herman, C.N. Burke, S.J. Perry, Wildl Dis 33, 925–929 (1997)

    CAS  Google Scholar 

  14. G. Darai, B. Matz, R.M. Flügel, A. Grafe, H. Gelderblom, H. Delius, Virology 104, 122–138 (1980)

    Article  CAS  PubMed  Google Scholar 

  15. G. Darai, L. Zöller, W. Hofmann, P. Möller, A. Schwaier, R.M. Flügel, Am. J. Primatol. 2, 177–189 (1981)

    Article  Google Scholar 

  16. G. Darai, K. Andres, H.G. Koch, H. Delius, H. Gelderblom, C. Samalecos, R.M. Flügel, Virology 126, 466–479 (1983)

    Article  CAS  PubMed  Google Scholar 

  17. H. Gelderblom, H. Bauer, H. Ogura, R. Wigand, A.B. Fischer, Int. J. Cancer 13, 246–253 (1974)

    Article  CAS  PubMed  Google Scholar 

  18. G. Darai, B. Matz, C.H. Schröder, R.M. Flügel, U. Berger, K. Munk, H. Gelderblom, J. Gen. Virol. 43, 541–551 (1979)

    Article  CAS  Google Scholar 

  19. H.G. Koch, H. Delius, B. Matz, R.M. Flügel, J. Clarke, G. Darai, J. Virol. 55, 86–95 (1985)

    CAS  PubMed  Google Scholar 

  20. U. Bahr, G. Darai, J. Virol. 75, 4854–4870 (2001)

    Article  CAS  PubMed  Google Scholar 

  21. T.C. Mettenleiter, B.G. Klupp, H. Granzow, Virus Res. 143, 222–234 (2009)

    Article  CAS  PubMed  Google Scholar 

  22. J.A. Plumb, in Viruses of Lower Vertebrate, ed. by W. Ahne, E. Kurstak (Springer, Heidelberg, 1989), pp. 198–216

    Google Scholar 

  23. R.P. Hedrick, O. Gilard, S. Yun, J.V. Spangenberg, R.W. Nordhausen, M.J. Kebus, H. Bercovier, A. Eldar, J Aquat Anim Health 12, 44–57 (2000)

    Article  Google Scholar 

  24. R.P. Hedrick, T.S. McDowell, J.M. Groff, S. Yun, W.H. Wingfield, Dis Aquat Org 11, 49–55 (1991)

    Article  Google Scholar 

  25. T. Kobayashi, T. Miyazaki, Fish Pathol 32, 89–95 (1997)

    Google Scholar 

  26. Y. Ueno, T. Kitao, S.N. Chen, T. Aoki, G.H. Kou, Gyobyo Kenkyu 27, 7–17 (1992)

    Google Scholar 

  27. L. Bekesi, I. Horvath, E. Kovacs-Gayer, G. Csaba, J. Appl. Ichthyol. 2, 190–192 (1986)

    Article  Google Scholar 

  28. T. Sano, H. Fukuda, M. Furukawa, Fish Pathol 20, 381–388 (1985)

    Google Scholar 

  29. S.J. Jung, T. Miyazaki, J. Fish Dis. 18, 211–220 (1995)

    Article  Google Scholar 

  30. P.E. McAllister, B.C. Lidgerding, R.L. Herman, L.C. Hoyer, J.J. Hankins, Wildl Dis 21, 199–204 (1985)

    CAS  Google Scholar 

  31. T. Yamamoto, R.K. Kelly, O. Nielsen, Arch. Virol. 9, 255–272 (1983)

    Google Scholar 

  32. K. Wolf, Fish Viruses and Fish Viral Diseases (Cornell University Press, Ithaca, NY, 1988)

    Google Scholar 

  33. T. Kimura, M. Yoshimizu, in Viruses of Lower Vertebrate, ed. by W. Ahne, E. Kurstak (Springer, Heidelberg, 1989), pp. 171–183

    Google Scholar 

  34. P.E. McAllister, R.L. Herman, Dis Aquat Org 6, 113–119 (1989)

    Article  Google Scholar 

  35. L. Leibovitz, S.S. Lebouitz, J. Fish Dis. 21, 199–204 (1985)

    Google Scholar 

  36. T. Miyazaki, K. Fujiwara, J. Kobara, M. Matsumoto, M. Abe, T. Nagano, J Aquat Anim Health 1, 85–93 (1989)

    Article  Google Scholar 

  37. S. Mellergard, B. Bloch, Dis Aquat Org 5, 151–155 (1988)

    Article  Google Scholar 

  38. M.L. Kent, M.S. Meyers, Dis Aquat Org 41, 237–239 (2000)

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors thank Dr. Kerstin Anders for providing skin lesion autopsies of Osmerus eperlanus.

Author information

Authors and Affiliations

  1. Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany

    Nurith J. Jakob

  2. Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany

    Roland Kehm

  3. Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany

    Hans R. Gelderblom

Authors
  1. Nurith J. Jakob
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roland Kehm
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hans R. Gelderblom
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nurith J. Jakob.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jakob, N.J., Kehm, R. & Gelderblom, H.R. A novel fish herpesvirus of Osmerus eperlanus . Virus Genes 41, 81–85 (2010). https://doi.org/10.1007/s11262-010-0490-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11262-010-0490-7

Keywords

Search

Navigation