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Identification of recombination between subgenotypes IA and IB of hepatitis A virus

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Abstract

Co-circulation of subgenotypes IA and IB of hepatitis A virus (HAV) has been reported in South Africa, South America, Europe, and the United States. In this study, phylogenetic and recombination analyses were performed for the first time on 31 complete HAV genomes from infected humans and simians. Three potentially significant intra-genotypic recombination events (I–III) were identified by recombination detection analysis. Recombination events I and II occurred between the lineages represented, respectively, by the Japanese isolate AH2 (AB020565, subgenotype IA) and the North African isolate MBB (M20273, subgenotype IB), giving rise to the recombinant Uruguayan isolate HAV5 (EU131373). Recombination event III occurred between the lineages represented, respectively, by the North African isolate MBB (M20273, subgenotype IB) and the German isolate GBM (X75215, subgenotype IA), resulting in the Italian isolate FG (X83302). The findings demonstrate that humans can be co-infected with different HAV subgenotypes and provide valuable hints for future research on HAV diversity.

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Acknowledgments

This work was supported by the National Grand Science and Technology Project of China (2008ZX10002-010, 2008ZX10002-015), “973” programs (2005CB522902, 2005CB522402), and Shanghai Science and Technology Committee (07DJ14006).

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Authors and Affiliations

  1. Key Laboratory of Medical Molecular Virology, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, Shanghai, China

    Wei Liu, Jianwei Zhai, Jing Liu & Youhua Xie

  2. Institute of Biomedical Sciences, Fudan University, Shanghai, 200032, China

    Wei Liu, Jing Liu & Youhua Xie

Authors
  1. Wei Liu
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  2. Jianwei Zhai
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  3. Jing Liu
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  4. Youhua Xie
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Corresponding author

Correspondence to Youhua Xie.

Additional information

Wei Liu and Jianwei Zhai contributed equally to this work.

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Liu, W., Zhai, J., Liu, J. et al. Identification of recombination between subgenotypes IA and IB of hepatitis A virus. Virus Genes 40, 222–224 (2010). https://doi.org/10.1007/s11262-009-0431-5

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  • DOI: https://doi.org/10.1007/s11262-009-0431-5

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