Skip to main content
SpringerLink
Log in

Genetic characterization of an H5N1 avian influenza virus with neurovirulence in ducks

  • Published:
Virus Genes Aims and scope Submit manuscript

Abstract

In this report, an H5N1 avian influenza virus, A/duck/Hubei/hangmei01/2006, which could lead to acute disease including neurovirulence and mortality in ducks, was isolated in brains of domestic ducks in spring of 2006. Molecular characterization of the genes revealed that this virus harbored the common characteristics of a highly pathogenic avian influenza (HPAI). Phylogenetic analyses demonstrated that this virus was a member of the Fujian-like virus sublineage. All eight genes except NA and PB2 had the closest genetic relatives to the human influenza virus A/China/GD01/2006. It might indicate that the virus A/duck/Hubei/hangmei01/2006 originated from southern China, resulting from the wild bird migration or poultry transportation, and indicate that more surveillance upon evolution and transmission of influenza viruses in ducks was urgent.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. H. Chen, Y. Li, Z. Li, J. Shi, K. Shinya, G. Deng, Q. Qi, G. Tian, S. Fan, H. Zhao, Y. Sun, Y. Kawaoka, J. Virol. 80, 5976–5983 (2006). doi:https://doi.org/10.1128/JVI.00110-06

    Article  CAS  Google Scholar 

  2. J. Liu, H. Xiao, F. Lei, Q. Zhu, K. Qin, X.W. Zhang, X.L. Zhang, D. Zhao, G. Wang, Y. Feng, J. Ma, W. Liu, J. Wang, G.F. Gao, Science 309, 1206 (2005). doi:https://doi.org/10.1126/science.1115273

    Article  CAS  Google Scholar 

  3. Y. Kawaoka, T.M. Chambers, W.L. Sladen, R.G. Webster, Virology 163, 247–250 (1988). doi:https://doi.org/10.1016/0042-6822(88)90260-7

    Article  CAS  Google Scholar 

  4. R.G. Webster, Y. Guan, M. Peiris, D. Walker, S. Krauss, N.N. Zhou, E.A. Govorkova, T.M. Ellis, K.C. Dyrting, T. Sit, D.R. Perez, K.F. Shortridge, J. Virol. 76, 118–126 (2002). doi:https://doi.org/10.1128/JVI.76.1.118-126.2002

    Article  CAS  Google Scholar 

  5. L.E. Perkins, D.E. Swayne, Avian Dis. 46, 53–63 (2002). doi:https://doi.org/10.1637/0005-2086(2002)046[0053:POAHKO]2.0.CO;2

    Article  Google Scholar 

  6. K.M. Sturm-Ramirez, T. Ellis, B. Bousfield, L. Bissett, K. Dyrting, J.E. Rehg, L. Poon, Y. Guan, M. Peiris, R.G. Webster, J. Virol. 78, 4892–4901 (2004). doi:https://doi.org/10.1128/JVI.78.9.4892-4901.2004

    Article  CAS  Google Scholar 

  7. N. Kishida, Y. Sakoda, N. Isoda, K. Matsuda, M. Eto, Y. Sunaga, T. Umemura, H. Kida, Arch. Virol. 150, 1383–1392 (2005). doi:https://doi.org/10.1007/s00705-004-0473-x

    Article  CAS  Google Scholar 

  8. D.J. Hulse-Post, K.M. Sturm-Ramirez, J. Humberd, P. Seiler, E.A. Govorkova, S. Krauss, C. Scholtissek, P. Puthavathana, C. Buranathai, T.D. Nguyen, H.T. Long, T.S. Naipospos, H. Chen, T.M. Ellis, Y. Guan, J.S. Peiris, R.G. Webster, Proc. Natl. Acad. Sci. USA 102, 10682–10687 (2005). doi:https://doi.org/10.1073/pnas.0504662102

    Article  CAS  Google Scholar 

  9. K.S. Li, Y. Guan, J. Wang, G.J. Smith, K.M. Xu, L. Duan, A.P. Rahardjo, P. Puthavathana, C. Buranathai, T.D. Nguyen, A.T. Estoepangestie, A. Chaisingh, P. Auewarakul, H.T. Long, N.T. Hanh, R.J. Webby, L.L. Poon, H. Chen, K.F. Shortridge, K.Y. Yuen, R.G. Webster, J.S. Peiris, Nature 430, 209–213 (2004). doi:https://doi.org/10.1038/nature02746

    Article  CAS  Google Scholar 

  10. E.C. Claas, A.D. Osterhaus, R. van Beek, J.C. De Jong, G.F. Rimmelzwaan, D.A. Senne, S. Krauss, K.F. Shortridge, R.G. Webster, Lancet 351, 472–477 (1998). doi:https://doi.org/10.1016/S0140-6736(97)11212-0

    Article  CAS  Google Scholar 

  11. H. Zhou, M. Jin, H. Chen, Q. Huag, Z. Yu, Virus Genes 32, 85–95 (2006). doi:https://doi.org/10.1007/s11262-005-5849-9

    Article  CAS  Google Scholar 

  12. Y. Ha, D.J. Stevens, J.J. Skehel, D.C. Wiley, Proc. Natl. Acad. Sci. USA 98, 11181–11186 (2001). doi:https://doi.org/10.1073/pnas.201401198

    Article  CAS  Google Scholar 

  13. J. Keawcharoen, A. Amonsin, K. Oraveerakul, S. Wattanodorn, T. Papravasit, S. Karnda, K. Lekakul, R. Pattanarangsan, S. Noppornpanth, R.A. Fouchier, A.D. Osterhaus, S. Payungporn, A. Theamboonlers, Y. Poovorawan, Acta Virol. 49, 277–280 (2005)

    CAS  PubMed  Google Scholar 

  14. H. Chen, G. Deng, Z. Li, G. Tian, Y. Li, P. Jiao, L. Zhang, Z. Liu, R.G. Webster, K. Yu, Proc. Natl. Acad. Sci. USA 101, 10452–10457 (2004). doi:https://doi.org/10.1073/pnas.0403212101

    Article  CAS  Google Scholar 

  15. A.C. Ward, Virus Genes 10, 253–260 (1995). doi:https://doi.org/10.1007/BF01701815

    Article  CAS  Google Scholar 

  16. Z. Li, H. Chen, P. Jiao, G. Deng, G. Tian, Y. Li, E. Hoffmann, R.G. Webster, Y. Matsuoka, K. Yu, J. Virol. 79, 12058–12064 (2005). doi:https://doi.org/10.1128/JVI.79.18.12058-12064.2005

    Article  CAS  Google Scholar 

  17. Y. Guan, J.S. Peiris, A.S. Lipatov, T.M. Ellis, K.C. Dyrting, S. Krauss, L.J. Zhang, R.G. Webster, K.F. Shortridge, Proc. Natl. Acad. Sci. USA 99, 8950–8955 (2002). doi:https://doi.org/10.1073/pnas.132268999

    Article  CAS  Google Scholar 

  18. Q. Zhu, H. Yang, W. Chen, W. Cao, G. Zhong, P. Jiao, G. Deng, K. Yu, C. Yang, Z. Bu, Y. Kawaoka, H. Chen, J. Virol. 82, 220–228 (2008). doi:https://doi.org/10.1128/JVI.00978-07

    Article  CAS  Google Scholar 

  19. P. Jiao, G. Tian, Y. Li, G. Deng, Y. Jiang, C. Liu, W. Liu, Z. Bu, Y. Kawaoka, H. Chen, J. Virol. 82, 1146–1154 (2008). doi:https://doi.org/10.1128/JVI.01698-07

    Article  CAS  Google Scholar 

  20. D.J. Hulse-Post, J. Franks, K. Boyd, R. Salomon, E. Hoffmann, H.L. Yen, R.J. Webby, D. Walker, T.D. Nguyen, R.G. Webster, J. Virol. 81, 8515–8524 (2007). doi:https://doi.org/10.1128/JVI.00435-07

    Article  CAS  Google Scholar 

  21. K. Shinya, S. Hamm, M. Hatta, H. Ito, T. Ito, Y. Kawaoka, Virology 320, 258–266 (2004)

    Article  CAS  Google Scholar 

  22. J.J. Zhou, J. Fu, D.Y. Fang, H.J. Yan, J. Tian, J.M. Zhou, J.P. Tao, Y. Liang, L.F. Jiang, Arch. Virol. 152, 1515–1521 (2007). doi:https://doi.org/10.1007/s00705-007-0985-2

    Article  CAS  Google Scholar 

Download references

Acknowledgment

This work was supported by 973 program (2005CB523003) and National Key Technology R&D Program (2006BAD06A11).

Author information

Authors and Affiliations

  1. Unit of Animal Infectious Disease, State Key Laboratory of Agriculture Microbiology, Huazhong Agricultural University, Wuhan, 430070, People’s Republic of China

    Wei Zou, Zhengjun Yu, Hongbo Zhou, Jiagang Tu & Meilin Jin

  2. Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, People’s Republic of China

    Meilin Jin

Authors
  1. Wei Zou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zhengjun Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hongbo Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jiagang Tu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Meilin Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Meilin Jin.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 65 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zou, W., Yu, Z., Zhou, H. et al. Genetic characterization of an H5N1 avian influenza virus with neurovirulence in ducks. Virus Genes 38, 263–268 (2009). https://doi.org/10.1007/s11262-008-0319-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11262-008-0319-9

Keywords

Search

Navigation