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Genetic analysis of H3 subtype influenza viruses isolated from domestic ducks in northern China during 2004–2005

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Abstract

The broad distribution and prevalence of H3 subtype influenza viruses in avian and mammalian hosts constitutes a global threat to both human and veterinary health. In this present study, six H3N8 influenza viruses isolated from domestic ducks during 2004–2005 in northern China were genetically and phylogenetically characterized. Sequence analysis showed that HA, NA, and M genes of all the six H3N8 isolates had a close relationship with those of Equine/Jilin/1/89 (H3N8) virus, which once caused outbreak in equine populations in northern China. The PB2 and PA genes of the viruses possessed the highest similarities with highly pathogenic avian H5N1 influenza viruses currently circulating in this region. These findings emphasize the importance of avian influenza virus surveillance in this region for understanding the genesis and emergency of novel reassortants with pandemic potential.

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Acknowledgments

This study was supported by the National Natural Scientific Foundation (30599431), National Key Technologies R&D Program (2006BAD06A01), National Basic Research Program (973) (2005CB523003), 863 program (2006AA10A205), EU AIV project FLUINNATE (SP5B-CT-2006-044161) and CAU Scientific Research Initiation Foundation (2008016). J. H. Liu was funded by Taishan Scholar Foundation. E. G. Brown was funded by CIHR Grant number TPA90188.

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Authors and Affiliations

  1. Laboratory of Infectious Diseases, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People’s Republic of China

    Juan Pu, Qin-Fang Liu, Ying-Ju Xia, Yu-Lei Fan & Jin-Hua Liu

  2. Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada

    Earl G. Brown

  3. The Shandong Animal Disease Control Center, Jinan, 250022, Shandong province, People’s Republic of China

    Fu-Lin Tian & Jin-Hua Liu

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  1. Juan Pu
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  2. Qin-Fang Liu
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  7. Jin-Hua Liu
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Correspondence to Jin-Hua Liu.

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Pu, J., Liu, QF., Xia, YJ. et al. Genetic analysis of H3 subtype influenza viruses isolated from domestic ducks in northern China during 2004–2005. Virus Genes 38, 136–142 (2009). https://doi.org/10.1007/s11262-008-0300-7

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  • DOI: https://doi.org/10.1007/s11262-008-0300-7

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