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Genetic characterization of avian influenza viruses isolated in Israel during 2000–2006

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Abstract

Our aim was to establish the phylogenetic and genetic relationships among avian influenza viruses (AIV) recently isolated from poultry in Israel. During this study we analyzed complete nucleotide sequences of two envelope (hemagglutinin and neuraminidase) and six internal genes (polymerase B1, polymerase B2, polymerase A, nucleoprotein, nonstructural, and matrix) of 29 selected H9N2 and six internal genes of five H5N1 viruses isolated in Israel during 2000–2006. Comparative genetic and phylogenetic analyses of these sequences revealed that the local H5N1 viruses are closely related to H5N1 viruses isolated in European, Asian, and Middle Eastern countries in 2005–2006. The H9N2 Israeli isolates, together with viruses isolated in Jordan and Saudi Arabia formed a single group. Our data support the claim that during recent years a new endemic focus of H9N2 has been formed in the Middle East. The introduction of H5N1 and co-circulation of these two subtypes of AIV in this region may augment the risk of potentially pandemic strains emergence.

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Acknowledgments

We thank Dr. Michael Lipkind and Dr. Esther Shihmanter for help in the beginning of our work, Mrs. Rivi Ascarelli-Goell, MSc and Mrs. Magda David, MSc, Mrs. Ekaterina Lapin, Dr. Ezra Rozenblut and Mrs. Faina Golender for excellent technical assistance. This study was supported by the Kameya Grant of the Israel Ministry of Absorption, by Research Grant No. IS–3679–05 from BARD, The United States-Israel Binational Agricultural Research and Development Fund, and by Grant No. 847–0319 from the Poultry Association of the Israel Ministry of Agriculture and Rural Development.

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Authors and Affiliations

  1. Division of Avian and Aquatic Diseases, Kimron Veterinary Institute, P.O.B. 12, Beit Dagan, 50250, Israel

    Natalia Golender, Alexander Panshin, Caroline Banet-Noach, Sagit Nagar, Irit Davidson & Shimon Perk

  2. Poultry Veterinary Services, Beit Dagan, Israel

    Shimon Pokamunski & Michael Pirak

  3. Rambam Medical Center, Haifa, Israel

    Yevgeny Tendler

  4. College of Veterinary Medicine, The University of Georgia, Athens, GA, USA

    Maricarmen García

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  1. Natalia Golender
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  2. Alexander Panshin
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  10. Shimon Perk
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Correspondence to Alexander Panshin.

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Golender, N., Panshin, A., Banet-Noach, C. et al. Genetic characterization of avian influenza viruses isolated in Israel during 2000–2006. Virus Genes 37, 289–297 (2008). https://doi.org/10.1007/s11262-008-0272-7

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