Skip to main content
SpringerLink
Log in

A new clade of hepatitis B virus subgenotype F1 from Peru with unusual properties

  • Published:
Virus Genes Aims and scope Submit manuscript

Abstract

There are eight genotypes A–H of hepatitis B virus (HBV). Most genotypes are further divided into subgenotypes. Genotypes and subgenotypes influence the natural course of infection and therapy. We analysed nine sera from HBV carriers from Peru. Using the small hepatitis B surface protein HBs, all samples could be grouped to genotype F. Sequencing of three complete Peruvian genomes showed that HBV from Peru belongs to subgenotype F1. Two of the genomes from HBeAg positive carriers coded surprisingly for a stop codon in the polymerase-ORF leading to a translational stop after 213 and 214 aa, respectively. The third isolate from an HBe Ag positive carrier had three deletions: aa 1–53 and aa 111–142 in preS. In addition nt. 2002–2087 in the HBc-ORF were deleted, leading to an HBc starting at aa 66.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. A. Kramvis, K. Arakawa, M.C. Yu, R. Nogueira, D.O. Stram, M.C. Kew, J. Med. Virol. 80, 27–46 (2008)

    Article  CAS  Google Scholar 

  2. H. Norder, A.-M. Couroucé, P. Coursaget, J.M. Echevarria, S.-D. Leef, I.K. Mushahwar, B.H. Robertson, S. Locarnini, L.O. Magnius, Intervirology 47, 289–309 (2004)

    Article  Google Scholar 

  3. S. Schaefer, World J. Gastroenterol. 13, 14–21 (2007)

    Article  CAS  Google Scholar 

  4. W.F. Leemans, H.L. Janssen, R.A. de Man, World J. Gastroenterol. 13, 2554–2567 (2007)

    Article  CAS  Google Scholar 

  5. J.H. Kao, J. Gastroenterol. Hepatol. 17, 643–650 (2002)

    Article  CAS  Google Scholar 

  6. C.J. Chu, M. Hussain, A.S. Lok, Gastroenterology 122, 1756–1762 (2002)

    Article  CAS  Google Scholar 

  7. A. Kramvis, M.C. Kew, J. Viral Hepat. 12, 456–464 (2005)

    Article  CAS  Google Scholar 

  8. H. Naumann, S. Schaefer, C.F. Yoshida, A.M. Gaspar, R. Repp, W.H. Gerlich, J. Gen. Virol. 74, 1627–1632 (1993)

    Article  CAS  Google Scholar 

  9. H. Kato, K. Fujiwara, R.G. Gish, H. Sakugawa, H. Yoshizawa, F. Sugauchi, E. Orito, R. Ueda, Y. Tanaka, T. Kato, Y. Miyakawa, M. Mizokami, World J. Gastroenterol. 11, 6295–6304 (2005)

    Article  CAS  Google Scholar 

  10. H. Norder, P. Arauz-Ruiz, L. Blitz, F.H. Pujol, J.M. Echevarria, L.O. Magnius, J. Gen. Virol. 84, 2083–2087 (2003)

    Article  CAS  Google Scholar 

  11. M. Devesa, C. Rodriguez, G. Leon, F. Liprandi, F.H. Pujol, J. Med. Virol. 72, 377–384 (2004)

    Article  CAS  Google Scholar 

  12. T.T. Huy, H. Ushijima, T. Sata, K. Abe, Arch. Virol. 151, 589–597 (2006)

    Article  CAS  Google Scholar 

  13. V.A. Mbayed, L. Barbini, J.L. Lopez, R.H. Campos, Arch. Virol. 146, 1803–1810 (2001)

    Article  CAS  Google Scholar 

  14. F.G. Pineiro y Leone, V.A. Mbayed, R.H. Campos, Virus Genes 27, 103–110 (2003)

    Article  CAS  Google Scholar 

  15. R.H. Campos, V.A. Mbayed, Y.L.F.G. Pineiro, J. Clin. Virol. 34(Suppl. 2), S8–S13 (2005)

    Article  CAS  Google Scholar 

  16. P. Arauz-Ruiz, H. Norder, B.H. Robertson, L.O. Magnius, J. Gen. Virol. 83, 2059–2073 (2002)

    Article  CAS  Google Scholar 

  17. T. Nakano, L. Lu, X. Hu, M. Mizokami, E. Orito, C. Shapiro, S. Hadler, B. Robertson, J. Gen. Virol. 82, 359–365 (2001)

    Article  CAS  Google Scholar 

  18. H. Norder, A.M. Couroucé, L.O. Magnius, Virology 198, 489–503 (1994)

    Article  CAS  Google Scholar 

  19. E. Alestig, C. Hannoun, P. Horal, M. Lindh, J. Clin. Microbiol. 39, 3200–3203 (2001)

    Article  CAS  Google Scholar 

  20. S. Schaefer, D. Glebe, U. Wend, J. Oyunbileg, W.H. Gerlich, J. Clin. Virol. 27, 30–37 (2003)

    Article  CAS  Google Scholar 

  21. S. Günther, B.C. Li, S. Miska, D.H. Krüger, H. Meisel, H. Will, J. Virol. 69, 5437–5444 (1995)

    PubMed  PubMed Central  Google Scholar 

  22. S. Günther, G. Sommer, F. von Breunig, A. Iwanska, T. Kalinina, M. Sterneck, H. Will, J. Clin. Microbiol. 36, 531–538 (1998)

    PubMed  PubMed Central  Google Scholar 

  23. K. Tamura, J. Dudley, M. Nei, S. Kumar, Mol. Biol. Evol. 24, 1596–1599 (2007)

    Article  CAS  Google Scholar 

  24. P.H. Franca, J.E. Gonzalez, M.S. Munne, L.H. Brandao, V.S. Gouvea, E. Sablon, B.O. Vanderborght, J. Clin. Microbiol. 42, 5015–5021 (2004)

    Article  CAS  Google Scholar 

  25. H. Okamoto, F. Tsuda, H. Sakugawa, R.I. Sastrosewinjo, M. Imal, Y. Miyakawa, M. Mayumi, J. Gen. Virol. 69, 2575–2583 (1988)

    Article  CAS  Google Scholar 

  26. M.L. Funk, D.M. Rosenberg, A.S. Lok, J. Viral Hepat. 9, 52–61 (2002)

    Article  CAS  Google Scholar 

  27. M. Arii, S. Takada, K. Koike, Oncogene 7, 397–403 (1992)

    CAS  PubMed  Google Scholar 

  28. J. Li, Z. Xu, Y. Zheng, D.L. Johnson, J.H. Ou, J. Virol. 76, 5875–5881 (2002)

    Article  CAS  Google Scholar 

  29. H.J. Kwun, K.L. Jang, Nucleic Acids Res. 32, 2202–2213 (2004)

    Article  CAS  Google Scholar 

  30. M.N. Mulders, V. Venard, M. Njayou, A.P. Edorh, A.O. Bola Oyefolu, M.O. Kehinde, J.J. Muyembe Tamfum, Y.K. Nebie, I. Maiga, W. Ammerlaan, F. Fack, S.A. Omilabu, A. Le Faou, C.P. Muller, J. Infect. Dis. 190, 400–408 (2004)

    Article  CAS  Google Scholar 

  31. M. Nassal, Intervirology 42, 100–116 (1999)

    Article  CAS  Google Scholar 

  32. R.E. Lanford, L. Notvall, H. Lee, B. Beames, J. Virol. 71, 2996–3004 (1997)

    CAS  PubMed  PubMed Central  Google Scholar 

  33. F. Birnbaum, M. Nassal, J. Virol. 64, 3319–3330 (1990)

    CAS  PubMed  PubMed Central  Google Scholar 

  34. P. Preikschat, A. Kazaks, A. Dishlers, P. Pumpens, D.H. Krüger, H. Meisel, FEBS Lett. 478, 127–132 (2000)

    Article  CAS  Google Scholar 

  35. V. Bruss, D. Ganem, Proc. Natl. Acad. Sci. USA 88, 1059–1063 (1991)

    Article  CAS  Google Scholar 

  36. V. Bruss, R. Thomssen, J. Virol. 68, 1643–1650 (1994)

    CAS  PubMed  PubMed Central  Google Scholar 

  37. V. Bruss, Virus Res. 106, 199–209 (2004)

    Article  CAS  Google Scholar 

  38. D. Glebe, M. Aliakbari, P. Krass, E. Knoop, K. Valerius, W.H. Gerlich, J. Virol. 77, 9511–9521 (2003)

    Article  CAS  Google Scholar 

  39. D. Glebe, S. Urban, E.V. Knoop, N. Cag, P. Krass, S. Grun, A. Bulavaite, K. Sasnauskas, W.H. Gerlich, Gastroenterology 129, 234–245 (2005)

    Article  CAS  Google Scholar 

  40. J. Le Seyec, P. Chouteau, I. Cannie, C. Guguen-Guillouzo, P. Gripon, J. Virol. 73, 2052–2057 (1999)

    CAS  PubMed  PubMed Central  Google Scholar 

  41. J. Le Seyec, P. Chouteau, I. Cannie, C. Guguen-Guillouzo, P. Gripon, J. Virol. 72, 5573–5578 (1998)

    CAS  PubMed  PubMed Central  Google Scholar 

  42. T. Santantonio, M.C. Jung, G. Pastore, G. Angarano, S. Gunther, H. Will, J. Hepatol. 26, 221–227 (1997)

    Article  CAS  Google Scholar 

  43. S. Märschenz, A.-S. Endres, A. Brinckmann, T. Heise, G. Kristiansen, P. Nürnberg, D.H. Krüger, S. Günther, H. Meisel, Gastroenterology 131, 765–780 (2006)

    Article  Google Scholar 

  44. Y.H. Hsieh, I.J. Su, H.C. Wang, W.W. Chang, H.Y. Lei, M.D. Lai, W.T. Chang, W. Huang, Carcinogenesis 25, 2023–2032 (2004)

    Article  CAS  Google Scholar 

  45. H.C. Wang, W.T. Chang, W.W. Chang, H.C. Wu, W. Huang, H.Y. Lei, M.D. Lai, N. Fausto, I.J. Su, Hepatology 41, 761–770 (2005)

    Article  Google Scholar 

  46. O. Kirschberg, C. Schuttler, R. Repp, S. Schaefer, J. Clin. Virol. 29, 39–43 (2004)

    Article  CAS  Google Scholar 

  47. C.A. Jursch, W.H. Gerlich, D. Glebe, S. Schaefer, O. Marie, O. Thraenhardt, Med. Microbiol. Immunol. 190, 189–197 (2002)

    Article  CAS  Google Scholar 

Download references

Acknowledgement

St. S. and J. S were supported by grant 10-1854-Scha I German Cancer research Foundation and grant Scha778/3-1 from DFG.

Author information

Author notes

  1. Jianguang Sun

    Present address: Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing, 100081, P.R. China

Authors and Affiliations

  1. Abteilung für Virologie, Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universität Rostock, Schillingallee 70, D-18057, Rostock, Germany

    Markus von Meltzer, Jianguang Sun, Anja May, Monika Radtke & Stephan Schaefer

  2. Laboratorio de Radioimmunoanálisis y Biología Molecular del Centro Nuclear Instituto Peruano de Energía Nuclear, Av. Canadá Nº 1470, San Borja, Lima, 41, Peru

    Silvia Vásquez

  3. Institute of Medical Virology, Justus Liebig University, 35392, Giessen, Germany

    Ulrike C. Wendt & Wolfram H. Gerlich

Authors
  1. Markus von Meltzer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Silvia Vásquez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jianguang Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ulrike C. Wendt
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Anja May
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wolfram H. Gerlich
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Monika Radtke
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Stephan Schaefer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stephan Schaefer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

von Meltzer, M., Vásquez, S., Sun, J. et al. A new clade of hepatitis B virus subgenotype F1 from Peru with unusual properties. Virus Genes 37, 225–230 (2008). https://doi.org/10.1007/s11262-008-0261-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11262-008-0261-x

Keywords

Search

Navigation