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Molecular relationships between type Asia 1 new strain from China and type O Panasia strains of foot-and-mouth-disease virus

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Abstract

The complete genome of Asia 1/HNK/CHA/05 strain of foot-and-mouth disease virus (FMDV) was sequenced, which was isolated from Chinese Hongkong in 2005. It is 8187 nt long in size and contains 5′-UTR, polyprotein region, and 3′-UTR. Polyprotein region can be divided into four parts of L, P1, P2 and P3. In this report, these six parts of the whole genome of the strain were compared with 12 reference strains using DNAStar and Simplot softwares. The comparison of P1 confirmed that Asia 1/HNK/CHA/05 has a high identity with nine type Asia 1 reference sequences from 85.9 to 92.6% (Ind/491/97 strain is the highest) but from 69.6 to 69.7% with three type O Panasia sequences. The identities of 5′-UTR, L, P2, P3 and 3′-UTR with three Panasia strains are from 89.0 to 90.6%, 92.5 to 93.4%, 94.8 to 95.5%, 96.0 to 96.7% and 90.7 to 92.5% separately, but with nine type Asia 1 strains are from 83.5 to 85.9%, 87.7 to 90.7%, 87.0 to 91.6%, 91.6 to 92.8% and 86.0 to 100% separately, which illuminates the closer relationship between Asia 1/HNK/CHA/05 and Panasia strains in 5′-UTR, L, nonstructural region and 3′-UTR although they do not belong to the same serotype. The SimPlot software was used to examine the authentic relationships of Asia 1/HNK/CHA/05 with 12 reference sequences. It was found that Asia 1/HNK/CHA/05 strain has a highest similarity with three Panasia strains especially Tibet/CHA/99 in 5′-UTR, L, nonstructural region and 3′-UTR but has a highest similarity with Asia 1/Ind/491/97 strain in P1 region, which suggested that the gene recombination had occurred around nucleotide position 1811 and 3971in the polyprotein region between Tibet/CHA/99 and Ind/491/97 to recombine the Asia 1/HNK/CHA/05 strain.

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Acknowledgments

We are thankful to National Foot-and-Mouth Disease Reference Laboratory of China (NFMDRLC) under Lanzhou Veterinary Research Institute (LVRI), Lanzhou, for providing the necessary facilities to carry out this work. This work has been supported by a grant from “Chinese national 973 project, No. 2005CB523201.” This work was also supported by National key Technology R&D program of China, No. 2006DAD06A03.

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Authors and Affiliations

  1. Key laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiologic Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Yanchangbao Xujiaping No.1, Lanzhou, Gansu, 730046, China

    Dong Li, You-Jun Shang, Zai-Xin Liu, Xiang-Tao Liu & Xue-Peng Cai

  2. Faculty of Animal Medicine, Gansu Agricultural University, Lanzhou, 730050, China

    Dong Li

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  1. Dong Li
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  2. You-Jun Shang
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  3. Zai-Xin Liu
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  5. Xue-Peng Cai
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Correspondence to Xiang-Tao Liu or Xue-Peng Cai.

Additional information

The nucleotide sequence data of Asia 1/HNK/CHA/05 strain reported in this article has been submitted to the Genbank nucleotide sequence database and has been assigned the accession number EF149010.

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Li, D., Shang, YJ., Liu, ZX. et al. Molecular relationships between type Asia 1 new strain from China and type O Panasia strains of foot-and-mouth-disease virus. Virus Genes 35, 273–279 (2007). https://doi.org/10.1007/s11262-006-0073-9

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  • DOI: https://doi.org/10.1007/s11262-006-0073-9

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