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Sequence analysis of a canine parvovirus isolated from a red panda (Ailurus fulgens) in China

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ABSTRACT

Canine parvovirus (CPV) was first recognized in the late 1970 s in dogs and has mutated and spread throughout the world in canid and felid species since then. In this study, a novel CPV was isolated from the endangered red panda (Ailurus fulgens) in China. Nucleotide and phylogenetic analysis of the capsid protein VP2 gene classified the red panda parvovirus (RPPV) as a CPV-2a type. Substitution of Val for Gly at the conserved 300 residue in RPPV presents an unusual variation in the CPV-2a amino acid sequence and is further evidence for the continuing evolution of the virus. The 300 residue is important in distinguishing the antigenicity and host range of CPVs. The clinical significance and population impact of RPPV infection in captive red pandas in China is unknown and is an important topic for future research.

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Acknowledgements

We appreciate the permission from the Beijing Zoo and the Kunming Wildlife Park to collect the samples from their red pandas. Thanks also to the Chinese National Disease Laboratory for supplying the reference strain of CPV. Sincere gratitude to Drs. Edward Dubovi and Colin Parrish for their ideas in helping to interpret the results of this study. Funding for this study came from the Wildlife Infectious Disease Project of the Institute of Zoology, Chinese Academy of Sciences, the Chinese State Forestry Administration and the American Association for the Advancement of Science.

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Author notes

  1. I. Kati Loeffler

    Present address: , 5 Stevens Street, Enfield, NH, 03748, USA

Authors and Affiliations

  1. Institute of Zoology, Chinese Academy of Sciences, 25 Beisihuan Xilu, Haidian District, Beijing, 100080, China

    Qin Qin, Ming Li & Fuwen Wei

  2. Graduate School of the Chinese Academy of Sciences, 25 Beisihuan Xilu, Haidian District, Beijing, 100080, China

    Qin Qin

  3. Smithsonian’s National Zoological Park, 3001 Connecticut Ave., NW, Washington, DC, 20008, USA

    I. Kati Loeffler

  4. National Veterinary Diagnostic Center, Ministry of Agriculture of the People’s Republic of China, No. 2 Yuanmingyuan xilu, Haidian, Beijing, 100094, China

    Kegong Tian

Authors
  1. Qin Qin
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  2. I. Kati Loeffler
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  3. Ming Li
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  5. Fuwen Wei
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Correspondence to Fuwen Wei.

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Qin, Q., Loeffler, I.K., Li, M. et al. Sequence analysis of a canine parvovirus isolated from a red panda (Ailurus fulgens) in China. Virus Genes 34, 299–302 (2007). https://doi.org/10.1007/s11262-006-0023-6

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  • DOI: https://doi.org/10.1007/s11262-006-0023-6

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