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Difference of Epstein–Barr virus isolates from Japanese patients and African Burkitt’s lymphoma cell lines based on the sequence of latent membrane protein 1

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Abstract

Sequence variations in the Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) gene have been described in many EBV-isolates. To characterize the genomic relationship between Japanese EBV and the EBV isolates of other countries, we analyzed the LMP1 nucleotide sequences in EBV positive cell lines and clinical specimens, including five African Burkitt’s lymphoma (BL) cell lines, a Japanese BL cell line, a B-lymphoblastoid cell line, a nasopharyngeal carcinoma hybrid cell line, six gastric carcinoma tissues, two peripheral blood mononuclear cells, and a B95-8 cell line, which contained the prototype EBV genome. We determined the C-terminal nucleotide sequences of LMP1 by PCR-direct sequencing analysis and characterized the sequence variation of Japanese isolates, made a phylogenetic tree from the sequence patterns of LMP1 by a neighbor-joining method. The results indicate that the Japanese EBV isolates are greatly different from the African BL isolates but are closely related to the China 1, which is a strain of Chinese EBV isolates.

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Acknowledgments

This work was supported by Grants-in-Aid Scientific Research (B: 15390150, 17390136) from the Ministry of Education, Science, Sports and Culture of Japan; and by the 2nd Term Comprehensive 10-year Strategy for Cancer Control from Ministry of Health and Welfare of Japan; and by the special Coordination Funds for Promoting Science and Technology from the Ministry of Education, Culture, Sports, Science, and Technology, the Japan Government.

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Authors and Affiliations

  1. Division of Biosignaling, Department of Biomedical Sciences, School of Life Science, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan

    Kyosuke Kanai, Yukio Satoh & Takeshi Sairenji

  2. Department of Cell Biology, The Cancer Institute of the Japanese Foundation for Cancer Research, 1-37-1 Kami-Ikebukuro, Toshima, Tokyo, 170-8455, Japan

    Yuriko Saiki

  3. Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, 311-3193, Japan

    Haruo Ohtani

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  1. Kyosuke Kanai
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  2. Yukio Satoh
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  3. Yuriko Saiki
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  4. Haruo Ohtani
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  5. Takeshi Sairenji
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Correspondence to Takeshi Sairenji.

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Kanai, K., Satoh, Y., Saiki, Y. et al. Difference of Epstein–Barr virus isolates from Japanese patients and African Burkitt’s lymphoma cell lines based on the sequence of latent membrane protein 1. Virus Genes 34, 55–61 (2007). https://doi.org/10.1007/s11262-006-0010-y

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  • DOI: https://doi.org/10.1007/s11262-006-0010-y

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