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The Goose Reovirus Genome Segment Encoding the Minor Outer Capsid Protein, σ1/σC, is Bicistronic and Shares Structural Similarities with its Counterpart in Muscovy Duck Reovirus

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Abstract

Reoviruses have recently been shown to be associated with disease in young geese and to be involved in epizooties of severe outcome in Hungary. To assess the genetic variability among these pathogenic goose reoviruses (GRVs), we sequenced the S4 genome segment of five GRV strains isolated from different diseased flocks. We found that the GRV S4 genome segment, consisting of two partially overlapping open reading frames (ORFs), shares substantial structural similarity with its counterpart in muscovy duck reoviruses (DRVs). ORF1 is predicted to encode a polypeptide highly similar to the p10 polypeptide of DRV, and ORF2 supposedly encodes the minor outer capsid protein, σ1/σC. In one of the five GRV strains examined, we identified a single uracil base insertion close to the middle of ORF2. This insertion resulted in a frameshift and in concomitant acquisition of a termination codon (UAA) a few codons downstream, apparently causing truncation of the C-terminal part of the protein. The functional consequences of this assumed mutation, which would result in loss of more than a half of the protein, have yet to be determined. Nonetheless, the sequence and structural similarities between the genome segment encoding σl/σC in GRVs and DRVs suggest that these viruses belong to a species distinct from other established species within subgroup 2 of orthoreoviruses.

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Authors and Affiliations

  1. Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, H-7623 , Pécs, Hungary

    Krisztián Bányai & György Szűcs

  2. CEVA-Phylaxia Biologicals Co. Ltd, Szállás u. 5, H-1107, Budapest, Hungary

    Vilmos Palya

  3. Veterinary Medical Research Institute, Hungarian Academy of Sciences, P.O. Box 18, 1581, Budapest, Hungary

    Mária Benkő

  4. Department of Medical Genetics and Child Development, Faculty of Medicine, University of Pécs, Szigeti út 12, H-7623, Pécs, Hungary

    Judit Bene, Viktória Havasi & Béla Melegh

  5. Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Szigeti út 12, H-7623, Pécs, Hungary

    György Szűcs

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  1. Krisztián Bányai
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  2. Vilmos Palya
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  3. Mária Benkő
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  4. Judit Bene
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  5. Viktória Havasi
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  7. György Szűcs
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Correspondence to Krisztián Bányai.

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Bányai, K., Palya, V., Benkő, M. et al. The Goose Reovirus Genome Segment Encoding the Minor Outer Capsid Protein, σ1/σC, is Bicistronic and Shares Structural Similarities with its Counterpart in Muscovy Duck Reovirus. Virus Genes 31, 285–291 (2005). https://doi.org/10.1007/s11262-005-3243-2

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  • DOI: https://doi.org/10.1007/s11262-005-3243-2

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