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Association between oxidative balance score and urinary incontinence in females: results from the national health and nutrition examination survey in 2005–2018

  • Urology - Original Paper
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Abstract

Purpose

Oxidative stress plays a crucial role in the pathogenesis of urinary incontinence (UI). This study aimed to assess the association between the oxidative balance score (OBS) and UI in adult females in the United States.

Methods

The study utilized data from the National Health and Nutrition Examination Survey database, spanning from 2005 to 2018. Weighted multivariate logistic regression, subgroup analyses, and restricted cubic spline regression were conducted to determine the odds ratio (OR) and 95% confidence intervals (95% CI) regarding the association between OBS and UI. Sensitivity analyses were performed to assess the robustness of the findings.

Results

A total of 7304 participants were enrolled in this study. After adjusting for potential confounders, participants with lower OBS were found to have a higher likelihood of experiencing stress, urge, and mixed incontinence (OR, 0.986; 95% CI 0.975–0.998; p = 0.022; OR, 0.978; 95% CI 0.963–0.993; p = 0.004; and OR, 0.975; 95% CI 0.961–0.990; p = 0.001). Lifestyle factors were strongly associated with the prevalence and frequency of UI. The results remained consistent, and no significant interaction effects were observed in the subgroup analyses. The prevalence of three types of UI exhibited a nonlinear inverted U-shaped trend with increasing in OBS and dietary OBS (p for nonlinear < 0.05).

Conclusion

Among females, the higher the OBS, the lower the prevalence of UI. Therefore, dietary and lifestyle-related antioxidant therapy for females with UI should receive attention and be subject to further investigation.

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Data availability statement

The original contributions presented in the study are included in the article/Supplementary material, further inquiries can be directed to the corresponding author.

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Acknowledgements

We thank all the contributors and participants in the National Health and Nutrition Examination Survey. We also thank Zhang Jing (Shanghai Tongren Hospital) for his work on the NHANES database. His outstanding work, nhanesR package and webpage, makes it easier for us to explore NHANES database.

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This research received no external funding.

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Author notes

  1. Ye Yuan first author.

Authors and Affiliations

  1. Department of Urology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China

    Ye Yuan, Wei Tan, Yinchao Huang, Hao Huang, Yadong Li, Yuanqing Gou, Shengjie Zeng & Zili Hu

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Contributions

YY: designed the research, collected and analyzed data, and wrote the original draft. WT and YH: assisted in the data analysis. HH and YL: assisted in the data collection. YG and SJ: assisted in manuscript preparation. ZH: had primary responsibility for the final content. All authors read and approved the final manuscript.

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Correspondence to Zili Hu.

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The studies involving human participants were reviewed and approved by National Center for Health Statistics. The participants provided their written informed consent to participate in this study.

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Yuan, Y., Tan, W., Huang, Y. et al. Association between oxidative balance score and urinary incontinence in females: results from the national health and nutrition examination survey in 2005–2018. Int Urol Nephrol 55, 2145–2154 (2023). https://doi.org/10.1007/s11255-023-03665-3

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