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Relationship between parathyroid oxyphil cell proportion and clinical characteristics of patients with chronic kidney disease

  • Nephrology - Original Paper
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Abstract

Background

Parathyroid glands consist of chief cells and oxyphil cells. The parathyroid oxyphil cell proportion increased dramatically in patients with chronic kidney disease (CKD). The importance of the oxyphil cell in the treatment of secondary hyperparathyroidism (SHPT) has been enhanced in recent years. The aim of this study was to explore the possible relationship between parathyroid oxyphil cell proportion and clinical features of patients with CKD.

Methods

From December 2010 to December 2018, 78 consecutive patients with CKD 5 who underwent parathyroidectomy (PTX) were reviewed. None of the patients had used Cinacalcet. Patients were divided into two groups according to their parathyroid oxyphil cell proportion. The mean parathyroid oxyphil cell proportion of all the patients was obtained. Group 1 consisted of 37 patients, the parathyroid oxyphil cell proportion of whom was more than or equal to mean proportion. Group 2 consisted of 41 patients, the parathyroid oxyphil cell proportion of whom was less than mean proportion. The demographic and biochemical data of the two groups were compared.

Results

Preoperative parathyroid hormone (PTH) and total weight of removed parathyroid glands in the patients of group 1were less than those in group 2. There was no difference between the two groups in terms of preoperative calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), age and dialysis years.

Conclusion

The parathyroid oxyphil cell proportion was associated with preoperative PTH and total weight of removed parathyroid glands in the patients with CKD. Patients with more parathyroid oxyphil proportion had lower preoperative PTH level and smaller total weight of the removed parathyroid glands.

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References

  1. Christie AC (1967) The parathyroid oxyphil cells. J Clin Pathol 20(4):591–602

    Article  CAS  Google Scholar 

  2. Tanaka Y et al (1996) Oxyphil Cell Function in Secondary Parathyroid Hyperplasia. Nephron 73(4):580–586

    Article  CAS  Google Scholar 

  3. Basile C, Lomonte C (2017) The function of the parathyroid oxyphil cells in uremia: still a mystery? Kidney Int 92(5):1046–1048

    Article  CAS  Google Scholar 

  4. Ritter C et al (2017) Paricalcitol and cinacalcet have disparate actions on parathyroid oxyphil cell content in patients with chronic kidney disease. Kidney Int 92(5):1217–1222

    Article  CAS  Google Scholar 

  5. Rottembourg J, Menegaux F (2019) Are oxyphil cells responsible for the ineffectiveness of cinacalcet hydrochloride in haemodialysis patients? Clin Kidney J 12(3):433–436

    Article  Google Scholar 

  6. Brown EM (1991) Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers. Physiol Rev 71(2):371–411

    Article  CAS  Google Scholar 

  7. Shi Y et al (2014) Functional and genetic studies of isolated cells from parathyroid tumors reveal the complex pathogenesis of parathyroid neoplasia. Proc Natl Acad Sci USA 111(8):3092–3097

    Article  CAS  Google Scholar 

  8. Nonaka D (2011) Study of parathyroid transcription factor Gcm2 expression in parathyroid lesions. Am J Surg Pathol 35(1):145–151

    Article  Google Scholar 

  9. Levin A et al (2007) Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int 71(1):31–38

    Article  CAS  Google Scholar 

  10. Torer N et al (2009) Predictors of early postoperative hypocalcemia in hemodialysis patients with secondary hyperparathyroidism. Transplant Proc 41(9):3642–3646

    Article  CAS  Google Scholar 

  11. Goodman WG et al (2000) Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 342(20):1478–1483

    Article  CAS  Google Scholar 

  12. Raggi P et al (2002) Cardiac calcification in adult hemodialysis patients A link between end-stage renal disease and cardiovascular disease? J Am Coll Cardiol 39(4):695–701

    Article  Google Scholar 

  13. Moe SM et al (2005) Long-term treatment of secondary hyperparathyroidism with the calcimimetic cinacalcet HCl. Nephrol Dial Transplant 20(10):2186–2193

    Article  CAS  Google Scholar 

  14. Howson P et al (2015) Oxyphil cell parathyroid adenomas causing primary hyperparathyroidism: a clinico-pathological correlation. Endocr Pathol 26(3):250–254

    Article  CAS  Google Scholar 

  15. Erickson LA et al (2002) Oxyphil parathyroid carcinomas: a clinicopathologic and immunohistochemical study of 10 cases. Am J Surg Pathol 26(3):344–349

    Article  Google Scholar 

  16. Erbil Y et al (2008) The positive effect of adenoma weight and oxyphil cell content on preoperative localization with 99mTc-sestamibi scanning for primary hyperparathyroidism. Am J Surg 195(1):34–39

    Article  Google Scholar 

  17. Sumida K et al (2011) Histopathological alterations of the parathyroid glands in haemodialysis patients with secondary hyperparathyroidism refractory to cinacalcet hydrochloride. J Clin Pathol 64(9):756–760

    Article  CAS  Google Scholar 

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Funding

This study was funded by the Science and Technology Commission of Shanghai Municipality [Grant Numbers 14411966100].

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Authors and Affiliations

  1. Department of Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China

    Yue Ding, Qiang Zou, Yiting Jin, Jian Zhou & Hongying Wang

Authors
  1. Yue Ding
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  2. Qiang Zou
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  3. Yiting Jin
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  4. Jian Zhou
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  5. Hongying Wang
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Corresponding author

Correspondence to Hongying Wang.

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All authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors. All procedures formed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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It was obtained from all individual participants included in the study.

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Ding, Y., Zou, Q., Jin, Y. et al. Relationship between parathyroid oxyphil cell proportion and clinical characteristics of patients with chronic kidney disease. Int Urol Nephrol 52, 155–159 (2020). https://doi.org/10.1007/s11255-019-02330-y

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  • DOI: https://doi.org/10.1007/s11255-019-02330-y

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