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Optical biopsy of bladder cancer using confocal laser endomicroscopy

  • Urology - Original Paper
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Abstract

Objective

Confocal laser endomicroscopy (CLE) is an emerging endoscopic technique that can provide in vivo histopathologic information. It may improve the diagnostic criteria for benign and neoplastic lesions of the bladder. In this study, we reported our experience with utilizing CLE imaging when treating bladder neoplasms, and investigated its diagnostic value with respect to histologic diagnosis.

Materials and methods

Twenty-one patients scheduled for diagnostic cystoscopy or transurethral resection of the bladder tumor were enrolled prospectively. CLE was performed after intravesical fluorescein administration and confocal video sequences were reviewed and analyzed retrospectively. Histopathology served as reference standard for comparison.

Results

Confocal laser endomicroscopy-based classification combined with white light cystoscopy (WLC) images was consistent with histopathology in 17 cases (81.0%). Consensus with histopathological results was found in six cases (85.7%) for low-grade urothelial carcinoma and eight cases (80.0%) for high-grade urothelial carcinoma.

Conclusion

Confocal laser endomicroscopy was proved to be a useful technique that could complement white light cystoscopy by providing real-time histopathological information of bladder lesions.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Project 81772706).

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Author notes

  1. Jie Wu and Yu-Chen Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China

    Jie Wu, Yu-Chen Wang, Bo Dai, Ding-Wei Ye & Yi-Ping Zhu

  2. Department of Oncology, Shanghai Medical College, Fudan University, No. 270 Dong an Road, Shanghai, 200032, People’s Republic of China

    Jie Wu, Yu-Chen Wang, Bo Dai, Ding-Wei Ye & Yi-Ping Zhu

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  1. Jie Wu
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  2. Yu-Chen Wang
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  3. Bo Dai
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Correspondence to Yi-Ping Zhu.

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The authors declare no conflict of interest.

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All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration with its later amendments.

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Informed consent was obtained from all individual participants included in the study.

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Wu, J., Wang, YC., Dai, B. et al. Optical biopsy of bladder cancer using confocal laser endomicroscopy. Int Urol Nephrol 51, 1473–1479 (2019). https://doi.org/10.1007/s11255-019-02197-z

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  • DOI: https://doi.org/10.1007/s11255-019-02197-z

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