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CT characteristics predict the response to everolimus or sirolimus of renal angiomyolipomas in patients with tuberous sclerosis complex

  • Nephrology-Original Paper
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Abstract

Objective

To investigate factors influencing the volume response of everolimus and sirolimus in tuberous sclerosis complex (TSC) associated-angiomyolipomas (AML).

Methods

A retrospective analysis of 30 cases of TSC-AML treated by mTOR inhibitors (everolimus 18 cases, and sirolimus 12 cases) between April 2014 and November 2017 at our center was carried out. Epidemiological data, therapeutic response and influence factors were reviewed and analyzed. Age, sex, associated with SEGA and/or LAM or not, plasma rapamycin concentration, AML volume at baseline, and mean CT value of AML in the maximum cross-section at baseline were analyzed as potential influencing factors.

Results

Eighteen patients with 32 lesions in everolimus group and 12 patients with 15 lesions in sirolimus group were included. There was no statistically significant difference of baseline characteristics except for involved side (P = 0.008) between two groups. The mean volume of AML was 1000 ± 1276 cm3 at baseline and 633 ± 1121 cm3 at 6 months after treatment (P < 0.001) in everolimus group, and 1984 ± 2861 cm3 at baseline and 1733 ± 2533 cm3 at 6 months after treatment (P = 0.001) in sirolimus group, respectively. The mean volume reduction of the AML in everolimus and sirolimus groups were 55.56% ± 23.79% and 30.5% ± 22.8% (P = 0.001). Stepwise multiple linear regression analysis revealed that factors influencing the short-term volume response of everolimus and sirolimus for TSC-associated AML were AML volume at baseline (P < 0.001 and 0.038, respectively) and mean CT value at baseline (P < 0.001 and 0.020, respectively). The rates of ≥ 50% volume reduction in high CT value group was much higher than that in low CT value group (90.5% vs. 18.2%, P < 0.001).

Conclusions

Everolimus at 10 mg daily might be more effective than sirolimus at 2 mg daily in treatment of patients with TSC-AML. AML volume and mean CT value at baseline were factors influencing the short-term volume response of everolimus or sirolimus for TSC-AML.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

AML:

Angiomyolipomas

LAM:

Lymphangioleiomyomatosis

SEGA:

Subependymal giant cell astrocytoma

TSC:

Tuberous sclerosis complex

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Acknowledgements

We thanked Dr. Xu Wang in Department of Urology, Peking Union Medical College Hospital for participating in manuscript revision work.

Funding

The present study was supported by National Natural Science Foundation of China (No. 81670611).

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Author notes

  1. Yushi Zhang and Yi Cai have contributed equally.

Authors and Affiliations

  1. Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China

    Wenda Wang, Hao Guo, Hanzhong Li & Yushi Zhang

  2. Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China

    Bing Shi & Hao Sun

  3. Department of Urology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, Hunan, China

    Yi Cai

Authors
  1. Wenda Wang
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  2. Hao Guo
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  3. Bing Shi
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  4. Hao Sun
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  5. Hanzhong Li
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  7. Yi Cai
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Contributions

YZ and YC conceived and designed the study. HL helped to evaluate the feasibility of the study, and guided the implementation. WW and HG performed the data collection. WW conducted data analysis and produced the manuscript. BS and HS helped to provide the image data.

Corresponding author

Correspondence to Yushi Zhang.

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The authors declare that they have no competing interests.

Ethics approval

The study was approved by the Ethics Committee of Peking Union Medical College Hospital (Beijing, China).

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Consent for publication was obtained from all the authors.

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Wang, W., Guo, H., Shi, B. et al. CT characteristics predict the response to everolimus or sirolimus of renal angiomyolipomas in patients with tuberous sclerosis complex. Int Urol Nephrol 51, 671–676 (2019). https://doi.org/10.1007/s11255-019-02093-6

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  • DOI: https://doi.org/10.1007/s11255-019-02093-6

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