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Relationship between fatigue symptoms and subjective and objective indicators in hemodialysis patients

  • Nephrology - Original Paper
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Abstract

Purpose

The purpose of the study was to investigate the major factors affecting fatigue symptoms and to examine the relationships between fatigue symptoms and subjective and objective indicators in patients on hemodialysis (HD).

Methods

Patients on HD who met the inclusion criteria were chosen from two grade A tertiary general hospitals by convenience sampling and cross-sectional survey methods.

Results

A total of 511 patients were included in the study. The morbidity rate of fatigue in patients on HD was 61.6%, and the median fatigue level was 3.91. Fatigue and subjective indicators showed a mild-moderate relationship (0.3 < all |r| < 0.6, all P < 0.001), whereas a weak correlation was found between fatigue and objective indicators (all |r| < 0.2, all P < 0.05). Multivariate analysis showed that subjective indicators, including employment, exercise time, appetite, the vitality of 36-item Short Form Health Survey, perceived social support, intrafamilial support, cramping, headache, chest tightness, and whole-body pain, as well objective indicator, such as serum intact parathyroid hormone levels, were the influence factors of fatigue in patients on HD.

Conclusion

The prevalence of fatigue symptoms was high and the level of fatigue was moderate in patients on HD. Subjective and objective indicators can both affect fatigue symptoms in patients on HD.

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Acknowledgements

We thank hemodialysis staff of the two dialysis centers who granted us support of the overall study process. We are also grateful to Manhua Zuo’s doctoral advisor, Xiuying Hu, Professor MD, who supervised the study design. We also thank Jun Tang, Deputy Director of the Nephrology Department, who rigorously monitored extraction of the indicators and communication with patients throughout the process, as well as the research staff, including Jianping Dai, Qing Long, and Miaomiao Xiang, who assisted in data collection and management. This research received funding from the Young and Middle-Aged Talents Project in Hubei Provincial Department of Education (Q20161905).

Author information

Author notes

  1. Manhua Zuo and Jun Tang are co-first authors.

Authors and Affiliations

  1. West China Nursing School/West China Hospital, Sichuan University, Chengdu, 610061, Sichuan, China

    Manhua Zuo & Xiuying Hu

  2. School of Medicine, Hubei Institute for Nationalities, Enshi, 445000, Hubei, China

    Manhua Zuo

  3. Department of Nephrology, The Central Hospital of Enshi Autonomous Prefecture, Enshi, 445000, Hubei, China

    Jun Tang, Miaomiao Xiang, Qing Long & Jianping Dai

Authors
  1. Manhua Zuo
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  2. Jun Tang
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  3. Miaomiao Xiang
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  4. Qing Long
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  5. Jianping Dai
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  6. Xiuying Hu
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Corresponding author

Correspondence to Xiuying Hu.

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All authors declare no conflicts of interest.

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Cite this article

Zuo, M., Tang, J., Xiang, M. et al. Relationship between fatigue symptoms and subjective and objective indicators in hemodialysis patients. Int Urol Nephrol 50, 1329–1339 (2018). https://doi.org/10.1007/s11255-018-1871-4

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  • DOI: https://doi.org/10.1007/s11255-018-1871-4

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