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Oncological outcomes and prognostic factors after nephron-sparing surgery in renal cell carcinoma

  • Urology - Original Paper
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Abstract

Purpose

To analyse the mid-term oncological results and to asses predictive factors for recurrence and survival after nephron-sparing surgery (NSS) for renal cell carcinoma.

Materials and methods

This is a retrospective study that includes 198 Partial Nephrectomies performed at our institution for malignant renal tumours. Demographic information and pathological characteristics were obtained, and completed statistical analysis was performed to assess predictors for overall survival (OS) and overall recurrence in our sample.

Results

The presence of positive surgical margins (PSM) in the surgical specimen was reported in 13.6 %. At a median of follow-up of 56.1 months, the non-adjusted cancer-specific mortality, DSS and OS were 100, and 93.4 %, respectively. In the bivariate analysis regarding predictive factors for recurrence, bilaterality and NSS indication (elective or imperative) were statistically significant (p = 0.03 and p = 0.05 respectively). On multivariate analysis only bilaterality was a significant predictor of recurrence (p = 0.03), while high Fuhrman grade was for survival (p = 0.006).

Conclusion

Our data suggest that patients with bilateral tumours have a higher incidence of local recurrence. Regarding overall survival, our data showed more risk of death at 5 years in those patients with high Fuhrman grade. No differences were found among PSM and negative surgical margins patients regarding oncological outcomes.

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Authors and Affiliations

  1. Department of Urology, Hospital Universitari de Bellvitge, University of Barcelona, 08907, Hospitalet de Llobregat, Barcelona, Spain

    Miguel Ángel López-Costea, Xavier Bonet, Jose Pérez-Reggeti, Begoña Etcheverry & Francisco Vigués

Authors
  1. Miguel Ángel López-Costea
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  2. Xavier Bonet
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  3. Jose Pérez-Reggeti
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  4. Begoña Etcheverry
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  5. Francisco Vigués
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Corresponding author

Correspondence to Miguel Ángel López-Costea.

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All the authors declare that they have no conflict of interest.

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This article does not contain any studies with animals or human participants performed by any of the authors.

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López-Costea, M.Á., Bonet, X., Pérez-Reggeti, J. et al. Oncological outcomes and prognostic factors after nephron-sparing surgery in renal cell carcinoma. Int Urol Nephrol 48, 681–686 (2016). https://doi.org/10.1007/s11255-016-1217-z

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  • DOI: https://doi.org/10.1007/s11255-016-1217-z

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