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Prognostic value of Ki67 and p63 expressions in bladder cancer patients who underwent radical cystectomy

  • Urology - Original Paper
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Abstract

Introduction

Radical cystectomy (RC) is the gold standard treatment for patients with high-risk non-muscle-invasive bladder cancer and muscle-invasive bladder cancer (MIBC) . However, despite aggressive treatment, mortality rates of patients are still high. Therefore, it is crucial to indentify some practical prognostic factors for cancer-specific survival in those patients to guide our therapeutic strategies.

Materials and methods

We included 103 patients treated with RC for urothelial bladder cancer (UBC) between July 2007 and June 2014 in our institution and analyzed their clinicopathological parameters. The mean follow-up was 22 months (range 2–89 months).

Results

Advanced tumor T stage, N stage, ABO blood type, a history of DM and positive p63 expression were independent factors for worse survival in all patients who underwent RC. Moreover, in female gender, high Ki67 expression was significant risk factor for cancer-specific survival (CSS) in MIBC patients.

Conclusion

Our study demonstrated that immunohistochemical expressions of Ki67 and p63 are potential prognostic factors for UBC patients who underwent RC.

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Author notes

    Authors and Affiliations

    1. Department of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People’s Republic of China

      Lujia Wang, Chenchen Feng, Peng Gao, Guanxiong Ding, Haowen Jiang, Zhong Wu & Qiang Ding

    2. Department of General Surgery, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People’s Republic of China

      Minwei Zhou

    3. Department of Pathology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People’s Republic of China

      Zhongwen Zhou

    Authors
    1. Lujia Wang
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    2. Minwei Zhou
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    3. Chenchen Feng
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    4. Peng Gao
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    Correspondence to Qiang Ding.

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    The authors declare that they have no conflict of interest.

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    This article does not contain any studies with human participants performed by any of the authors.

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    Informed consent was obtained from all individual participants included in the study.

    Additional information

    Lujia Wang, Minwei Zhou and Chenchen Feng have contributed equally to this work.

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    Wang, L., Zhou, M., Feng, C. et al. Prognostic value of Ki67 and p63 expressions in bladder cancer patients who underwent radical cystectomy. Int Urol Nephrol 48, 495–501 (2016). https://doi.org/10.1007/s11255-015-1197-4

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    • DOI: https://doi.org/10.1007/s11255-015-1197-4

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