Abstract
We conducted the first-regenerative medicine cellular therapy for underactive bladder (UAB) in an FDA-approved, compassionate-use IND trial to evaluate treatment safety and potential clinical efficacy of autologous muscle-derived stem cells (AMDC) on a patient with UAB. No study-related adverse events or side effects were reported. In the 1-year follow-up period, the subject denied any gross hematuria, urgency, frequency or infection. A reduction in maximum cystometric capacity from 844 to 663 mL was observed, and the patient was able to void small amounts but continues to require self-catheterization 1 year after AMDC injection. Intradetrusor injection of AMDC is safe, minimally invasive and a promising treatment option for the UAB.
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Chancellor MB, Diokno A (2014) CURE-UAB: shedding light on the underactive bladder syndrome. Int Urol Nephrol 46(Suppl. 1):S1. doi:10.1007/s11255-014-0789-8
Miyazato M, Yoshimura N, Chancellor MB (2013) The other bladder syndrome: underactive bladder. Rev Urol 15(1):11–22
Barendrecht MM, Oelke M, Laguna MP, Michel MC (2007) Is the use of parasympathomimetics for treating an underactive urinary bladder evidence-based? BJU Int 99(4):749–752. doi:10.1111/j.1464-410X.2006.06742.x
Huard J, Yokoyama T, Pruchnic R, Qu Z, Li Y, Lee JY, Somogyi GT, de Groat WC, Chancellor MB (2002) Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction. Gene Ther 9(23):1617–1626. doi:10.1038/sj.gt.3301816
Carr LK, Robert M, Kultgen PL, Herschorn S, Birch C, Murphy M, Chancellor MB (2013) Autologous muscle derived cell therapy for stress urinary incontinence: a prospective, dose ranging study. J Urol 189(2):595–601. doi:10.1016/j.juro.2012.09.028
Peters KM, Dmochowski RR, Carr LK, Robert M, Kaufman MR, Sirls LT, Herschorn S, Birch C, Kultgen PL, Chancellor MB (2014) Autologous muscle derived cells for treatment of stress urinary incontinence in women. J Urol 192(2):469–476. doi:10.1016/j.juro.2014.02.047
Acknowledgments
The authors wish to thank the Robert B. and Ann S. Aikens Urology Research Fund for supporting UAB research.
Conflict of interest
Ryan Pruchnic is an employee of Cook Myosite. Michael B. Chancellor has financial interest and a consultant relationship with Cook Myosite. There are no other conflicts of interest related to this publication to report.
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Levanovich, P.E., Diokno, A., Hasenau, D.L. et al. Intradetrusor injection of adult muscle-derived cells for the treatment of underactive bladder: pilot study. Int Urol Nephrol 47, 465–467 (2015). https://doi.org/10.1007/s11255-015-0924-1
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DOI: https://doi.org/10.1007/s11255-015-0924-1