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Cinacalcet may improve oxidative DNA damage in maintenance hemodialysis patients: an observational study

  • Nephrology - Original Paper
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Abstract

Background

Oxidative stress is accepted as a non-classical cardiovascular risk factor in patients on maintenance hemodialysis (HD). The aim of this study was to evaluate the impact of cinacalcet on oxidative stress biomarkers, oxidative DNA damage (8-hydroxy-2′-deoxyguanosine/deoxyguanosine), endothelial function (FMD %) and carotid artery intima-media thickness (CIMT) in HD patients.

Methods

Forty-two chronic HD patients with secondary hyperparathyroidism undergoing 60 mg/day cinacalcet treatment with a follow-up of 6 months and 38 age- and sex-matched healthy individuals were included in this prospective study. Plasma malondialdehyde (MDA) levels and 8-hydroxy-2′-deoxyguanosine/deoxyguanosine ratio (8-OHdG/dG) were determined as oxidative stress markers. Superoxide dismutase (SOD), paraoxonase (PON), catalase (CAT), carbonic anhydrase (CAN) and glutathione peroxidase (GPx) activities were measured as antioxidants. FMD % and CIMT were assessed by ultrasonography.

Results

MDA levels were decreased; SOD, PON, CAT, CAN and GPx activities were increased after 6 months of cinacalcet treatment in HD patients. Although CIMT remained stabile, there was a significant improvement in FMD % as well as a notable reduction trend in 8-OHdG/dG ratio after 6 months of treatment.

Conclusion

Our data have demonstrated that cinacalcet improves oxidative stress, genomic damage, endothelial function and increases antioxidant protection in HD patients after 6 months of treatment.

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Conflict of interest

None declared.

Author information

Authors and Affiliations

  1. Department of Nephrology, Kartal Research and Training Hospital, 34890, Istanbul, Turkey

    Elif Ari

  2. Department of Cardiology, Kafkas University, Kars, Turkey

    Yuksel Kaya

  3. Department of Biochemistry, Yuzuncu Yil University, Van, Turkey

    Halit Demir

  4. Department of Nephrology, Marmara University, Istanbul, Turkey

    Ebru Asicioglu & Hakki Arikan

  5. Department of Nephrology, Yeditepe University, Istanbul, Turkey

    Zehra Eren

  6. Department of Statistics, Yuzuncu Yil University, Van, Turkey

    Eray Celik

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  1. Elif Ari
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  2. Yuksel Kaya
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  3. Halit Demir
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Correspondence to Elif Ari.

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Ari, E., Kaya, Y., Demir, H. et al. Cinacalcet may improve oxidative DNA damage in maintenance hemodialysis patients: an observational study. Int Urol Nephrol 46, 1843–1849 (2014). https://doi.org/10.1007/s11255-014-0723-0

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  • DOI: https://doi.org/10.1007/s11255-014-0723-0

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