Abstract
Purpose
The purpose of the study was to investigate the effect of ABO blood groups and Rhesus (Rh) factor on prognosis of patients undergoing radical cystectomy.
Materials and methods
In this study, total number of 290 patients who underwent radical cystectomy between January 1990 and September 2012 were evaluated retrospectively. Patients were grouped as O and non-O according to ABO antigens; also positive and negative according to Rh factor. Parameters such as age, sex, stage, lymph node involvement and positive surgical margins were investigated. Disease-free and overall survival rates have been compared. Multivariate analysis were performed to determine independent prognostic factors.
Results
A total of 260 (89.7 %) male and 30 (10.3 %) female patients participated in the study. Mean follow-up was 37.7 ± 18.9 months. A total of 180 patients were non-O (62.1 %),while the 110 patients had the blood group O (37.9 %). The number of Rh positive and negative patients were 247 (85.2 %) and 43 (14.8 %), respectively. According to the univariate and multivariate analyses, ABO blood groups and Rh factor did not exhibit any significant impact on overall and disease-specific survival.
Conclusion
ABO blood group and Rh factor were not associated with the prognosis of bladder cancer patients who underwent radical cystectomy. However, prospective studies are needed in larger patient series for further evaluations.
Similar content being viewed by others
References
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics. CA Cancer J Clin 2009(59):225–249
Hautmann RE, Abol-Enein H, Hafez K, Haro I, Mansson W, Mills RD et al (2007) World Health Organization (WHO) Consensus Conference in Bladder Cancer. Urin divers Urol 69(1 Suppl):17–49
Stenzl A, Cowan NC, De Santis M, Jakse G, Kuczyk MA, Merseburger AS et al (2011) Treatment of muscle-invasive and metastatic bladder cancer: update of the EAU guidelines; European Association of Urology (EAU). Eur Urol 59(6):1009–1018
Ghoneim MA, Abdel-Latif M, el-Mekresh M, Abol-Enein H, Mosbah A, Ashamallah A et al (2008) Radical cystectomy for carcinoma of the bladder: 2,720 consecutive cases 5 years later. J Urol 180:121–127
Shariat SF, Karakiewicz PI, Palapattu GS, Lotan Y, Rogers CG, Amiel GE et al (2006) Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the Bladder Cancer Research Consortium. J Urol 176(6):2414–2422
Madersbacher S, Hochreiter W, Burkhard F, Thalmann GN, Danuser H, Markwalder R et al (2003) Radical cystectomy for bladder cancer today—a homogeneous series without neoadjuvant therapy. J Clin Oncol 21(4):690–696
Canter D, Guzzo T, Resnick M, Magerfleisch L, Sonnad S, Bergey M et al (2008) The presence of lymphovascular invasion in radical cystectomy specimens from patients with urothelial carcinoma portends a poor clinical prognosis. BJU Int 102(8):952–957
Sánchez-Ortiz RF, Huang WC, Mick R, Van Arsdalen KN, Wein AJ et al (2003) An interval longer than 12 weeks between the diagnosis of muscle invasion and cystectomy is associated with worse outcome in bladder carcinoma. J Urol 169(1):110–115
Clark PE, Stein JP, Groshen SG, Cai J, Miranda G, Lieskovsky G et al (2005) Radical cystectomy in the elderly: comparison of clincal outcomes between younger and older patients. Cancer 104(1):36–43
Thalmann GN, Stein JP (2008) Outcomes of radical cystectomy. BJU Int 102(9 Pt B):1279–1288
Landsteiner K (1900) Zur Kenntnis der antifermentativen, lytischen and agglutinierenden Wirkungen des Blutserums und der Lymphe. Zentralbl Bakteriol 27:357–362
Graziano SL, Tatum AH, Gonchoroff NJ (1997) Blood group antigen A and flow cytometric analysis in resected early stage non-small cell lung cancer. Clin Cancer Res 3:87–93
Zmijewski CM (1978) Immunohematology, 3rd edn. Appleton Century Crofts, New York
Aird I, Bentall HH, Roberts JA (1953) A relationship between cancer of stomach and the ABO blood groups. Br Med J 1:799–801
Wolpin BM, Chan AT, Hartge P, Chanock SJ, Kraft P, Hunter DJ et al (2009) ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst 101:424–431
Moldvay J, Scheid P, Wild P, Nabil K, Siat J, Borrelly J et al (2000) Predictive survival markers in patients with surgically resected non-small cell lung carcinoma. Clin Cancer Res 6:1125–1134
Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, Melbye M et al (2010) Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol 172:1280–1285
Wolpin BM, Kraft P, Gross M, Helzlsouer K, Bueno-de-Mesquita HB, Steplowski E et al (2010) Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Cancer Res 70:1015–1023
Malmström PU, Busch C, Norlen BJ, Andersson B (1988) Expression of ABH blood group isoantigen as a prognostic factor in transitional cell bladder carcinoma. Scand J Urol Nephrol 22:265–270
Summers JL, Coon JS, Ward RM, Falor WH, Miller AW III, Weinstein RS (1983) Prognosis in carcinoma of the urinary bladder upon tissue blood group ABH and Thompsen-Friedenreich antigen status and karyotype of the initial tumor. Cancer Res 43:93–99
Costantini M, Fassio T, Canobbio L, Landucci M, Resasco M, Boccardo F (1990) Role of blood groups as prognostic factors in primary breast cancer. Oncology 47:308–312
Rahbari NN, Bork U, Hinz U et al (2012) AB0 blood group and prognosis in patients with pancreatic cancer. BMC Cancer 28(12):319–328
Torun YA, Kaynar LG, Karakükcü Ç, Yay M, Kurnaz F, Mutlu H, Çetin M, Eser B (2012) Turk J Haematol 29:97–98
Reid ME, Mohandas N (2004) Red blood cellblood group antigens: structure and function. Semin Hematol 41:93–117
Dall’olio F (1996) Protein glycosylation in cancer biology: an overview. Clin Mol Pathol 49:126–135
Le Pendu J, Marionneau S, Cailleau-Thomas A, Rocher J, Le Moullac-Vaidye B, Clément M (2001) ABH and Lewis histo-blood group antigens in cancer. APMIS 109:9–31
Iodice S, Maisonneuve P, Botteri E, Sandri MT, Lowenfels AB (2010) ABO blood group andcancer. Eur J Cancer 46:3345–3350
Kaffenberger SD, Morgan TM, Stratton KL, Boachie AM, Barocas DA, Chang SS et al (2012) ABO blood group is a predictor of survival in patients undergoing surgery for renal cell carcinoma. BJU Int 110(11 Pt B):E641–E646
Catalona WJ (1981) Practical utility of specific red cell adherence test in bladder cancer. Urology 18:113–117
Klatte T, Xylinas E, Rieken M, Kluth LA, Rouprêt M, Pycha A et al (2013) Impact of ABO blood type on outcomes of patients with primary non-muscle-invasive bladder cancer. J Urol. doi:10.1016/j.juro.2013.11.106
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
Additional information
Recently, Klatte et al. [30] demonstrated O blood group as an independent predictor for reccurence and progression in NMIBC.
Rights and permissions
About this article
Cite this article
Süer, E., Özcan, C., Gökçe, İ. et al. Do blood groups have effect on prognosis of patients undergoing radical cystectomy?. Int Urol Nephrol 46, 1521–1526 (2014). https://doi.org/10.1007/s11255-014-0698-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11255-014-0698-x