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Atrophy in specimens of radical prostatectomy: is there topographic relation to high-grade prostatic intraepithelial neoplasia or cancer?

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Abstract

Introduction

It is controversial whether there is any relationship of proliferative inflammatory atrophy (PIA) to high-grade prostatic intraepithelial neoplasia (HGPIN) and cancer (CA). It has been suggested a topographic relation and a potential of the proliferative epithelium in PIA to progress to HGPIN and/or CA. The aim of this study was to analyze in radical prostatectomies a possible topographic relation of the lesions.

Materials and methods

A total of 3,186 quadrants from 100 whole-mount consecutive surgical specimens were examined. The frequency of quadrants showing: only PIA, PIA+CA, PIA+HGPIN, or PIA+HGPIN+CA was determined. Extent and distance between the lesions were evaluated by a semiquantitative point-count method previously described. We also studied foci with partial or complete atrophy without inflammation. The statistical methods included the Kruskal–Wallis and the Mann–Whitney tests and the Spearman correlation coefficient.

Results

The mean (range) of quadrants showing only PIA, PIA+CA, PIA+HGPIN, and PIA+HGPIN+CA was 3.29 (0–21), 2.51 (0–11), 0.77 (0–6), and 0.44 (0–4), respectively (P < 0.01). Most of the foci of PIA were significantly located in a distance >5 than <5 mm from HGPIN or CA. There was no significant correlation between extent of PIA (P = 0.64, r = 0.05) with extent of HGPIN. There was a significant negative correlation of extent of PIA (P = 0.01, r = −0.27) with extent of CA. Similar results were found considering foci either with or without inflammation. Chronic inespecific inflammation was not seen in foci of partial atrophy.

Conclusion

A topographic relation of PIA to HGPIN and/or CA was not supported by our study.

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Authors and Affiliations

  1. School of Medicine, State University of Campinas, Campinas, Brazil

    Antonio A. Brasil, Wagner J. Favaro, Valeria H. Cagnon, Ubirajara Ferreira & Athanase Billis

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  1. Antonio A. Brasil
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  2. Wagner J. Favaro
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  3. Valeria H. Cagnon
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  4. Ubirajara Ferreira
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  5. Athanase Billis
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Correspondence to Athanase Billis.

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Brasil, A.A., Favaro, W.J., Cagnon, V.H. et al. Atrophy in specimens of radical prostatectomy: is there topographic relation to high-grade prostatic intraepithelial neoplasia or cancer?. Int Urol Nephrol 43, 397–403 (2011). https://doi.org/10.1007/s11255-010-9803-y

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