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Expression profile and prognostic importance in prostate lesions of the reverse transcriptase component of human telomerase (hTERT) and of cyclin-dependent kinase inhibitor p57 (p57kip2a)

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An Erratum to this article was published on 08 July 2008

Abstract

Objectives

To investigate expression of the reverse transcriptase component of human telomerase (hTERT) and of cyclin-dependent kinase inhibitor p57 (p57kip2a) in prostate neoplasms and evaluate the relationship between these proteins and the Gleason score.

Methods

hTERT and p57kip2a antibodies were studied by immunohistochemical methods in 70 prostate adenocarcinomas (33 high-grade and 37 low-grade carcinomas), 29 benign prostate hyperplasias, and 19 prostatic intraepithelial neoplasias (PIN). Only nuclear staining was evaluated with p57kip2a whereas both nuclear and nucleolar staining were evaluated with hTERT.

Results

Immunohistochemical histologic scores (HSCOREs) of hTERT were significantly higher in the PIN group than in the hyperplasia group (P = 0.03). hTERT HSCOREs were not significantly different between hyperplasias and carcinomas or between low and high-grade carcinomas. p57kip2a HSCOREs were significantly higher in hyperplasias than other groups, and in PINS than carcinomas, but did not differ significantly between low and high-grade carcinomas. A significant negative correlation was observed between hTERT and p57kip2a (P = 0.007) in the hyperplasia group. No such correlation was found in PINs and carcinomas.

Conclusions

This study suggests that p57kip2a is down-regulated in the malignant side of the spectrum of prostate carcinogenesis. Loss of p57kip2a control on hTERT might have an important role in the development of prostate cancer.

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Authors and Affiliations

  1. Department of Pathology, School of Medicine, University of Kirikkale, Kirikkale, Turkey

    Pınar Atasoy, Onder Bozdogan & Sebnem Ayva

  2. Department of Urology, School of Medicine, University of Kirikkale, Saglık Sokak, Kirikkale, 71100, Turkey

    Erdal Yilmaz & Ertan Batislam

Authors
  1. Pınar Atasoy
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  2. Erdal Yilmaz
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  3. Onder Bozdogan
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  4. Sebnem Ayva
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  5. Ertan Batislam
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Corresponding author

Correspondence to Erdal Yilmaz.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s11255-008-9430-z

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Atasoy, P., Yilmaz, E., Bozdogan, O. et al. Expression profile and prognostic importance in prostate lesions of the reverse transcriptase component of human telomerase (hTERT) and of cyclin-dependent kinase inhibitor p57 (p57kip2a). Int Urol Nephrol 41, 55–60 (2009). https://doi.org/10.1007/s11255-008-9399-7

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  • DOI: https://doi.org/10.1007/s11255-008-9399-7

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