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The investıgatıon of GSTT1, GSTM1 and SOD polymorphism in bladder cancer patıents

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Abstract

Glutathione S transferases (GSTT1, GSTM1, GSTP1) are enzymes that activate the detoxification of endogenous and exogenous agents. The genetic polymorphism in these genes may change the response of individuals to environmental toxicants. The genetic polymorphisms of GSTT1, GSTM1, GSTP1 have been studied extensively in the determination of individual cancer risks. Some studies showed a strong relationship between polymorphism of GSTs and superoxidedismutase enzymes. Using the polymerase chain reaction (PCR) the prevalence of genetic polymorphisms of GSTT1, GSTM1 and MnSOD (Manganese Superoxide Dismurase) was investigated in 104 cases and controls to seek any association with the risk of bladder cancer. The frequency of GSTT1 +/+ polymorphism was 65% (33/51) in the cases and 79% (42/53) in the controls. The frequency of the GSTM1 +/+ polymorphism was 33% (17/51) in the cases and 58% (31/53) in the controls. The frequency of the GSTM1 null genotype was 42% (22/53) in the controls and 68% (34/51) in the patients. The frequency of the SOD AA genotype was 36% (17/51) in the cases and 33% (19/53) in the controls. There was no association between the GSTT1 and SOD polymorphism and bladder cancer incidence. The incidence of the GSTM1 null genotype was increased in bladder cancer patients compared to controls (OR = 1.755, 95% CI = 1.119–2.751).

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Authors and Affiliations

  1. Department Of Medical Biology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey

    Müjgan Cengiz, Ahmet Ozaydin & Anil Cagla Ozkilic

  2. Department of Urology, SSK Okmeydanı Hospital, Istanbul, Turkey

    Galip Dedekarginoglu

  3. İ.U. Cerrahpasa Tip Fakultesi, Temel Bilimler Binasi, Tıbbi Biyoloji ABD, 34093, Cerrahpasa, Istanbul, Turkey

    Ahmet Ozaydin

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  1. Müjgan Cengiz
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  2. Ahmet Ozaydin
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Correspondence to Ahmet Ozaydin.

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Cengiz, M., Ozaydin, A., Ozkilic, A.C. et al. The investıgatıon of GSTT1, GSTM1 and SOD polymorphism in bladder cancer patıents. Int Urol Nephrol 39, 1043–1048 (2007). https://doi.org/10.1007/s11255-007-9179-9

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  • DOI: https://doi.org/10.1007/s11255-007-9179-9

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