Skip to main content

Advertisement

Log in

The Aging Kidney: A Review – Part I

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. National Institute on Aging. Strategic Plan for Fiscal years 2001–2005. Available at: http://www.nia.nih.gov/strat-plan/2001–2005 Accessed: March 7, 2002.

  2. Lim HA. The average life expectancy will reach 90 years. Nature Online, 2001.

  3. A Frocht H. Fillit (1984) ArticleTitleRenal disease in the geriatric patient J Am Geriatr Soc 32 IssueID1 28–43 Occurrence Handle6197436

    PubMed  Google Scholar 

  4. PF Faubert JG. Porush (1998) Hypertension in the Elderly Renal Disease in the Elderly EditionNumber2 Marcel Dekker Inc NY 343–396

    Google Scholar 

  5. J Boe S Humerfelt F. Wedervang (1957) ArticleTitleThe blood pressure in a population. Blood pressure readings and height and weight determinations in the adult population of the city of Bergen Acta Med Scand 321 IssueIDSuppl 1–336

    Google Scholar 

  6. AR Dyer J Stamler RB Shekelle et al. (1977) ArticleTitleHypertension in the elderly Med Clin NA 61 513–529

    Google Scholar 

  7. AP Avolio SG Chen RP Wang et al. (1983) ArticleTitleEffects of aging on changing arterial compliance and left ventricular load in a Northern Chinese urban community Circulation 68 50–58 Occurrence Handle6851054

    PubMed  Google Scholar 

  8. JM Kotchen HE McKean TA. Kotchen (1984) ArticleTitleBlood pressure trends with aging Hypertension 4 IssueIDSuppl III 128–134

    Google Scholar 

  9. SJ Phillips WM O’Fallen JP. Whisnant (1988) ArticleTitleA population-based model for predicting blood pressure Mayo Clin Proc 63 700–706 Occurrence Handle3386310

    PubMed  Google Scholar 

  10. InstitutionalAuthorNameJoint National Committee (1985) ArticleTitleHypertension prevalence and the status of awareness, treatment and control in the United States Hypertension 7 457–468

    Google Scholar 

  11. VL Burt JA Cutler M Higgins et al. (1995) ArticleTitleTrends in the prevalence, awareness, treatment, and control of hypertension in the adult US population Hypertension 26 60–69 Occurrence Handle7607734

    PubMed  Google Scholar 

  12. J Staessen A Amery R. Fafard (1990) ArticleTitleIsolated systolic hypertension in the elderly J Hypertens 8 393–405 Occurrence Handle2163412

    PubMed  Google Scholar 

  13. CE. Cohen (1975) ArticleTitlePrevalence of hypertension among the elderly in an urban community J Am Geriatr Soc 23 165–168 Occurrence Handle1117118

    PubMed  Google Scholar 

  14. DJ Curb NO Borhani G Entwisle et al. (1985) ArticleTitleDeterminants of isolated systolic hypertension Am J Epidemiol 121 371–376 Occurrence Handle4014126

    PubMed  Google Scholar 

  15. Landers SJ. Hypertension guide reveals more patients at risk. Amer Med News 2003; January: 46.

  16. I Hajjar T. Kotchen (2003) ArticleTitleTrends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988–2000 JAMA 290 IssueID2 199–206 Occurrence Handle10.1001/jama.290.2.199 Occurrence Handle12851274

    Article  PubMed  Google Scholar 

  17. A Heidland W Gerabek K. Sebekova (2001) ArticleTitleFranz Volhard and Theodor Fahr: achievements and controversies in their research in renal disease and hypertension J Hum Hypertens 15 IssueID1 5–16 Occurrence Handle10.1038/sj.jhh.1001130 Occurrence Handle11223997

    Article  PubMed  Google Scholar 

  18. A. Agrest (2000) ArticleTitleThe renin saga (article in Spanish) Medicina (B Aires) 60 IssueID1 37–45

    Google Scholar 

  19. E Ritz S Kuster M. Zeier (1994) ArticleTitleClinical nephrology in 19th century Germany Am J Nephrol 14 IssueID4–6 443–447 Occurrence Handle7847483

    PubMed  Google Scholar 

  20. MacMahon HE. Malignant nephrosclerosis – a reappraisal. Pathol Decennial 1966–1975; 529–566.

  21. B Castleman RH. Smithwick (1943) ArticleTitleThe relation of vascular disease to the hypertensive state Based on a study of renal biopsies from 100 hypertensive patients JAMA 121 1256

    Google Scholar 

  22. DG Oreopoulos N. Dimkovic (2003) ArticleTitleGeriatric nephrology is coming of age J Am Soc Nephrol 14 1099–1101 Occurrence Handle10.1097/01.ASN.0000067656.48829.0E Occurrence Handle12660346

    Article  PubMed  Google Scholar 

  23. E. Bercovich (2002) ArticleTitleA new target for urology: aging and renal function Urol Int 69 IssueID2 91–94 Occurrence Handle10.1159/000065553 Occurrence Handle12187035

    Article  PubMed  Google Scholar 

  24. RL Kane JG Ouslander IB. Abrass (Eds) (1994) Essentials of Clinical Geriatrics EditionNumber3 McGraw-Hill, Inc, New York

    Google Scholar 

  25. Faubert PF, Porush JG. Renal Disease in the Elderly, 2nd edn. Marcel Dekker, Inc., 1998.

  26. C. Baylis (1997) ArticleTitleThe aging kidney Nephrology 15 178–186

    Google Scholar 

  27. M. Epstein (1996) ArticleTitleAging and the kidney J Am Soc Nephrol 7 1106–1122 Occurrence Handle8866401

    PubMed  Google Scholar 

  28. RD Lindeman JD Tobin NW. Shock (1984) ArticleTitleAnatomy and physiology. Association between blood pressure and the rate of decline in renal function with age Kidney Int 26 861–868 Occurrence Handle6533397

    PubMed  Google Scholar 

  29. RD. Lindeman (1993) ArticleTitleRenal physiology and pathophysiology of aging Contrib Nephrol 105 1–12

    Google Scholar 

  30. K Ishida H Ishida M Narita et al. (2001) ArticleTitleFactors affecting renal function in 119 985 adults over three years QJM 94 IssueID10 541–550 Occurrence Handle10.1093/qjmed/94.10.541 Occurrence Handle11588213

    Article  PubMed  Google Scholar 

  31. B. Clark (2000) ArticleTitleBiology of renal aging in humans Adv Ren Replace Ther 7 IssueID1 11–21 Occurrence Handle10672914

    PubMed  Google Scholar 

  32. DM. Roxe (1991) ArticleTitleAging and renal function Compr Ther 17 IssueID2 13–19

    Google Scholar 

  33. RD Lindeman R. Goldman (1986) ArticleTitleAnatomic and physiologic age changes in the kidney Exp Gerontol 21 IssueID4–5 379–406 Occurrence Handle10.1016/0531-5565(86)90044-6 Occurrence Handle3545873

    Article  PubMed  Google Scholar 

  34. SV. Jassal (2001) ArticleTitleGeriatric nephrology units: The way of the future Int Urol Nephrol 32 IssueID3 469–474 Occurrence Handle10.1023/A:1017509305946 Occurrence Handle11583373

    Article  PubMed  Google Scholar 

  35. RG Luke LN. Beck (1999) ArticleTitleGerontologizing nephrology J Am Soc Nephrol 10 IssueID8 1824–1827 Occurrence Handle10446952

    PubMed  Google Scholar 

  36. BR. Meyer (1989) ArticleTitleRenal function in aging J Am Geriatr Soc 37 IssueID8 791–800 Occurrence Handle2666487

    PubMed  Google Scholar 

  37. AM. Davison (1998) ArticleTitleRenal disease in the elderly Nephron 80 IssueID1 6–16 Occurrence Handle10.1159/000045119 Occurrence Handle9730697

    Article  PubMed  Google Scholar 

  38. BR Gilbert ED Vaughan SuffixJr. (1990) ArticleTitlePathophysiology of the aging kidney Clin Geriatr Med 6 IssueID1 13–30 Occurrence Handle2405974

    PubMed  Google Scholar 

  39. D Fliser E Ritz E. Franek (1995) ArticleTitleRenal reserve in the elderly Semin Nephrol 15 IssueID5 463–467 Occurrence Handle8525149

    PubMed  Google Scholar 

  40. LH. Beck (1998) ArticleTitleChanges in renal function with aging Clin Geriatr Med 14 IssueID2 199–209 Occurrence Handle9536101

    PubMed  Google Scholar 

  41. RD. Lindeman (1998) ArticleTitleIs the decline in renal function with normal aging inevitable? Geriatr Nephrol Urol 8 IssueID1 7–9 Occurrence Handle10.1023/A:1008294000258 Occurrence Handle9650041

    Article  PubMed  Google Scholar 

  42. LH. Beck (2000) ArticleTitleThe aging kidney: defending a delicate balance of fluid and electrolytes Geriatrics 55 IssueID4 26–28

    Google Scholar 

  43. A. Young (1997) ArticleTitleAgeing and physiological functions Philos Trans R Soc Lond B Biol Sci 352 IssueID1363 1837–1843 Occurrence Handle10.1098/rstb.1997.0169 Occurrence Handle9460068

    Article  PubMed  Google Scholar 

  44. WJ Mulder HF. Hillen (2001) ArticleTitleRenal function and renal disease in the elderly: Part II PMID 12 IssueID4 327–333

    Google Scholar 

  45. RD. Lindeman (1990) ArticleTitleOverview: renal physiology and pathophysiology of aging Am J Kidney Diseases XVI IssueID4 275–282

    Google Scholar 

  46. Obialo CI, Allison–Ottey S. Kidney disease in elderly minorities. 2002; 94(8 Suppl): 76S–82S.

  47. Zawada ET Jr. Geriatr Nephrol 1992; 32(4): 310–316.

  48. Lonergan ET. Aging and the kidney: adjusting treatment to physiologic change. Geriatrics 1988; 43(3): 27–30, 32–33.

    Google Scholar 

  49. KJ. Radke (1994) ArticleTitleRenal physiology series: Par 6 of 8 The aging kidney: structure, function, and nursing practice implications. ANNA J 21 IssueID4 181–190

    Google Scholar 

  50. W Goldring et al. (1940) ArticleTitleRenal blood flow JCI 19 739

    Google Scholar 

  51. DF Davies NW. Shock (1950) ArticleTitleRenal blood flow JCI 29 496–500 Occurrence Handle15415454

    PubMed  Google Scholar 

  52. JH Miller RK McDonald NW. Shock (1951) ArticleTitleThe renal extraction of p-amino-hippurate in the aged individual J Gerontol 6 213–216 Occurrence Handle14850706

    PubMed  Google Scholar 

  53. Wesson LG. Renal blood flow. Physiology of the Human Kidney, 1969.

  54. RK McDonald DH Solomon NW. Shock (1951) ArticleTitleAging as a factor in the renal hemodynamic changes induced by a standardized pyrogen. JCI 5 457–462

    Google Scholar 

  55. DF Davies NW. Shock (1950) ArticleTitleAge changes in glomerular filtration rate: effective renal plasma flow and tubular excretory capacity in adult males J Clin Invest 29 496–507 Occurrence Handle15415454

    PubMed  Google Scholar 

  56. NK Hollenberg DF Adams HS Solomon et al. (1974) ArticleTitleSenescence and the renal vasculature in normal man Circ Res 34 309–316 Occurrence Handle4362036

    PubMed  Google Scholar 

  57. JW Rowe R Andres JD Tobin et al. (1976) ArticleTitleThe effect of age on creatinine in man: a cross-sectional and longitudinal study J Gerontol 31 155–163 Occurrence Handle1249404

    PubMed  Google Scholar 

  58. RD Lindeman J Tobin NW. Shock (1985) ArticleTitleLongitudinal studies on the rate of decline in renal function with age J Am Geriatr Soc 33 278–285 Occurrence Handle3989190

    PubMed  Google Scholar 

  59. Wesson LG Jr. Renal hemodynamics in physiological states. In: Physiology of the Human Kidney. New York: Grune and Stratton, 1969: 96–108.

  60. JW Rowe R Andres JD. Tobin (1976) ArticleTitleAge-adjusted standards for creatinine clearance Ann Intern Med 84 567–569 Occurrence Handle1275359

    PubMed  Google Scholar 

  61. Faubert PF, Porush JG. Renal Disease in the Elderly, 2nd edn. Chapter 1: Anatomy and Physiology. Marcel Dekker, Inc., 1998: 4.

  62. LK Bowker RS Briggs PJ Gallagher DR. Robertson (1992) ArticleTitleRaised blood urea in the elderly: a clinical and pathological study Postgrad Med J 68 IssueID797 174–179 Occurrence Handle1589374

    PubMed  Google Scholar 

  63. DA Feinfeld H Guzik CP Carvounis et al. (1995) ArticleTitleSequential changes in renal function tests in the old old: results from the Bronx Longitudinal Aging Study J Am Geriatr Soc 43 IssueID4 412–414 Occurrence Handle7706633

    PubMed  Google Scholar 

  64. Lindeman RD et al. Glomerular filtration rate: Longitudinal studies. Kidney Int 1984; 26: 861; J Am Geriatr Soc 1985; 33: 278

    Google Scholar 

  65. JW Rowe et al. (1976) ArticleTitleGlomerular filtration rate: Longitudinal studies J Gerontol 31 155 Occurrence Handle1249404

    PubMed  Google Scholar 

  66. TM Johnson JM Sands JG. Ouslander (2002) ArticleTitleA prospective evaluation of the glomerular filtration rate in older adults with frequent nighttime urination J Urol 167 146–150 Occurrence Handle10.1097/00005392-200201000-00034 Occurrence Handle11743294

    Article  PubMed  Google Scholar 

  67. NW. Shock (1950) ArticleTitleAge changes in renal function Rev Med Lleye 5 IssueID20 649–651

    Google Scholar 

  68. RD Lindeman et al. (1987) ArticleTitleHypertension and the kidney Nephron 47 IssueIDSuppl 2 62–67

    Google Scholar 

  69. Lindeman RD. Personal Communication, 2003.

  70. JK. Healy (1968) ArticleTitleClinical assessment of glomerular filtration rate by different forms of creatinine clearance and a modified urinary phenolsulphonphthalein excretion test Am J Med 44 IssueID3 348–358 Occurrence Handle10.1016/0002-9343(68)90106-X Occurrence Handle5641299

    Article  PubMed  Google Scholar 

  71. T Adachi M Kawamura M Owada K. Hiramori (2001) ArticleTitleEffect of age on renal functional and orthostatic vascular response in healthy men Clin Exp Pharmacol Physiol 28 IssueID11 877–880 Occurrence Handle10.1046/j.1440-1681.2001.03536.x Occurrence Handle11703387

    Article  PubMed  Google Scholar 

  72. D Fliser E. Ritz (1996) ArticleTitleRenal haemodynamics in the elderly Nephrol Dial Transplant 11 IssueIDSuppl 9 2–8

    Google Scholar 

  73. G Fuiano S Sund G Mazza et al. (2001) ArticleTitleRenal hemodynamic response to maximal vasodilating stimulus in health older subjects Kidney Int 59 1052–1058 Occurrence Handle10.1046/j.1523-1755.2001.0590031052.x Occurrence Handle11231360

    Article  PubMed  Google Scholar 

  74. RK McDonald DH Solomon NW. Shock (1951) ArticleTitleIs the decrease in renal blood flow with age due to intraluminal vascular pathology or an increase in renal vascular resistance from vasoconstriction? JCI 5 457–462

    Google Scholar 

  75. NK Hollenberg DF Adams HS Solomon et al. (1974) ArticleTitleSenescence and the renal vasculature in normal man Circ Res 34 IssueID3 309–316 Occurrence Handle4362036

    PubMed  Google Scholar 

  76. TD Lee SuffixJr RD Lindeman MJ Yiengst NW. Shock (1966) ArticleTitleInfluence of age on cardiovascular and renal responses to tilting J Appl Physiol 21 55–61 Occurrence Handle5903944

    PubMed  Google Scholar 

  77. C Baylis M Fredericks C Wilson et al. (1990) ArticleTitleRenal vasodilatory response to intravenous glycine in the aging rat kidney Am J Kidney Dis 15 244–251 Occurrence Handle2305764

    PubMed  Google Scholar 

  78. D Fliser M Zeier R Nowack E. Ritz (1993) ArticleTitleRenal functional reserve in healthy elderly subjects J Am Soc Nephrol 3 1371–1377 Occurrence Handle8439649

    PubMed  Google Scholar 

  79. Faubert PF, Porush JG. Renal Disease in the Elderly, 2nd edn. Chapter 2: Anatomy and Physiology. Marcel Dekker, Inc., 1998: 7–10.

  80. M. Lye (1984) ArticleTitleElectrolytic disorders in the elderly Clin Endocrinol Metab 13 IssueID2 377–398 Occurrence Handle10.1016/S0300-595X(84)80027-4 Occurrence Handle6386235

    Article  PubMed  Google Scholar 

  81. DF Davies NW. Shock (1950) ArticleTitleMaximum tubular transport capacity JCI 29 496–500 Occurrence Handle15415454

    PubMed  Google Scholar 

  82. RD Lindeman HC Van Buren LG. Raisz (1960) ArticleTitleOsmolar concentrating ability in healthy young men and hospitalized patients without renal disease N Eng J Med 262 1306–1309

    Google Scholar 

  83. RD Lindeman et al. (1966) ArticleTitleAbility to dilute and concentrate urine: diluting ability J Lab Clin Med 68 206–223 Occurrence Handle5912596

    PubMed  Google Scholar 

  84. JH Miller NW. Shock (1953) ArticleTitleAbility to dilute and concentrate urine: response to antidiuretic hormone J Gerontol 8 446 Occurrence Handle13130853

    PubMed  Google Scholar 

  85. M Epstein NK. Hollenberg (1976) ArticleTitleAge as a determinant of renal sodium conservation in normal man J Lab Clin Med 87 411–417

    Google Scholar 

  86. JF. Macias Nuñea (1980) ArticleTitleRenal handling of sodium in old people A functional study. Age Aging 7 178–181

    Google Scholar 

  87. JL Kirkland M Lye DW Levy AK. Banerjee (1983) ArticleTitlePatterns of urine flow and electrolyte excretion in healthy elderly people Br Med J 287 1665–1667

    Google Scholar 

  88. CW. Gottschalk (1976) ArticleTitleRenal nerves and sodium excretion Ann Rev Physiol 41 229–240 Occurrence Handle10.1146/annurev.ph.41.030179.001305

    Article  Google Scholar 

  89. C Flood C Gherondache G Pincus et al. (1967) ArticleTitleThe metabolism and secretion of aldosterone in elderly subjects J Clin Invest 46 960–966 Occurrence Handle6026101

    PubMed  Google Scholar 

  90. K Tsunoda K Abe T Goto et al. (1986) ArticleTitleEffect of age on the renin-angiotensin-aldosterone system in normal subjects: Simultaneous measurement of active and inactive renin, renin substrate and aldosterone in plasma J Clin Endocrinol Metab 62 384–389 Occurrence Handle3510226

    PubMed  Google Scholar 

  91. J Higaki R Morishita T Ogihara M. Nishiura (1989) ArticleTitleEffects of aging on human plasma renin: Simultaneous multiple assays of enzyme activity and immunoactivity of plasma renin Acta Endocrinol 120 81–86 Occurrence Handle2643250

    PubMed  Google Scholar 

  92. J Duggan J Nussberger S Kilfeather K. O’Malley (1993) ArticleTitleAging and human hormonal and pressor responsiveness to angiotensin II infusion with simultaneous measurements of exogenous and endogenous all Am J Hypertens 6 641–647 Occurrence Handle8217025

    PubMed  Google Scholar 

  93. FC Luft CE Grim N Fineberg MC. Weinberger (1979) ArticleTitleEffects of volume expansion and contraction in normotensive whites, blacks and subjects of different ages Circulation 59 643–650 Occurrence Handle421305

    PubMed  Google Scholar 

  94. M Ohashi N Fujio H Nawata et al. (1987) ArticleTitleHigh plasma concentration of human natriuretic polypeptide in aged man J Clin Endocrinol Metab 64 81–85 Occurrence Handle3023430

    PubMed  Google Scholar 

  95. D Leosco N Ferrara P Landino et al. (1996) ArticleTitleEffects of age on the role of a trial natriuretic factor in renal adaptation to physiologic variations of dietary salt intake J Am Soc Nephrol 7 1045–1051 Occurrence Handle8829120

    PubMed  Google Scholar 

  96. BA Clark D Elahi FH. Epstein (1989) ArticleTitleAge and dose related differences in responses to atrial natriuretic peptide in man Kidney Int 35 282A

    Google Scholar 

  97. BGD Haller H Zust S Shaw et al. (1987) ArticleTitleEffects of posture and aging on circulating atrial natriuretic peptide levels in man J Hypertens 5 551–556 Occurrence Handle2963064

    PubMed  Google Scholar 

  98. AC Tan TL Jansen EF Termond et al. (1992) ArticleTitleKinetics of atrial natriuretic peptide in young and elderly subjects Eur J Clin Pharmacol 42 449–452 Occurrence Handle1387608

    PubMed  Google Scholar 

  99. LA Frassetto RC Morris SuffixJr A. Sebastian (1996) ArticleTitleEffect of age on blood acid–base composition in adult humans: Role of age-related renal functional decline Am J Physiol 271 F1114–F1122 Occurrence Handle8997384

    PubMed  Google Scholar 

  100. BN Agarwal FG. Cabebe (1980) ArticleTitleRenal acidification in elderly subjects Nephron 26 291–295 Occurrence Handle7453916

    PubMed  Google Scholar 

  101. H Yamada B Sacktor J. Kinsella (1992) ArticleTitleAge-associated changes in ammoniagenesis in isolated rat renal tubule segments Am J Physiol 262 F600–F605 Occurrence Handle1566873

    PubMed  Google Scholar 

  102. JW Rowe NW Shock RA. DeFronzo (1976) ArticleTitleThe influence of age on the renal response to water deprivation in man Nephron 17 270–278 Occurrence Handle951013

    PubMed  Google Scholar 

  103. JH Helderman RE Vestal JW Rowe et al. (1978) ArticleTitleThe response of arginine vasopressin to intravenous ethanol and hypertonic saline in man: the impact of aging J Gerontol 33 39–47 Occurrence Handle618965

    PubMed  Google Scholar 

  104. HH Bengele RS Mathias JH Perkin EA. Alexander (1981) ArticleTitleUrinary concentrating defect in the aged rat Am J Physiol 240 IssueID2 F147–F150 Occurrence Handle7468799

    PubMed  Google Scholar 

  105. JH Miller NW. Shock (1953) ArticleTitleAge differences in the renal tubular response to antidiuretic hormone J Gerontol 8 446–450 Occurrence Handle13130853

    PubMed  Google Scholar 

  106. E Takazakura N Sawabu A Handa et al. (1972) ArticleTitleIntrarenal vascular changes with age and disease Kidney Int 2 224–230 Occurrence Handle4657923

    PubMed  Google Scholar 

  107. BA Clark RP Shannon RM Rosa FH. Epstein (1994) ArticleTitleIncreased susceptibility to thiazide-induced hyponatremia in the elderly J Am Soc Nephrol 5 1106–1111 Occurrence Handle7849250

    PubMed  Google Scholar 

  108. BA Clark RM Rosa FH Epstein et al. (1992) ArticleTitleAltered dopaminergic responses in hypertension Hypertension 19 IssueID6 Pt 1 589–594 Occurrence Handle1592453

    PubMed  Google Scholar 

  109. JH Miller RK McDonald NW. Shock (1952) ArticleTitleAge changes in the maximal rate of renal tubular reabsorption of glucose Maximum tubular transport capacity. J Gerontol 7 196–200

    Google Scholar 

  110. S Adler RD Lindeman MJ Yiengst et al. (1968) ArticleTitleEffect of acute acid loading on urinary acid excretion by the aging human kidney J Lab Clin Med 72 278–289 Occurrence Handle5671202

    PubMed  Google Scholar 

  111. BN Agarwal FG. Cabebe (1980) ArticleTitleRenal acidification in elderly subjects Nephron 26 291–295 Occurrence Handle7453916

    PubMed  Google Scholar 

  112. JH Miller RD McDonald NW. Shock (1952) ArticleTitleAge changes in the maximal rate of renal tubular reabsorption of glucose J Gerontol 7 196–200 Occurrence Handle14927900

    PubMed  Google Scholar 

  113. JW Rowe NW Shock RA. DeFronzo (1976) ArticleTitleThe influence of age on the renal response to water deprivation in man Nephron 17 270–278 Occurrence Handle951013

    PubMed  Google Scholar 

  114. NJ Vanden Noortgate WH Janssens MB Afschrift NH. Lameire (2001) ArticleTitleRenal function in the oldest-old on an acute geriatric ward Int Urol Nephrol 32 IssueID4 531–537 Occurrence Handle10.1023/A:1014454031451 Occurrence Handle11989541

    Article  PubMed  Google Scholar 

  115. JY Tiao JB Semmens JR Masarei MM. Lawrence-Brown (2002) ArticleTitleThe effect of age on serum creatinine levels in an aging population: Relevance to vascular surgery Cardiovasc Surg 10 IssueID5 445–451 Occurrence Handle10.1016/S0967-2109(02)00056-X Occurrence Handle12379401

    Article  PubMed  Google Scholar 

  116. Coresh J. Personal communication, 2003.

  117. H Tauchi K Tsuboi J. Okutomi (1971) ArticleTitleAge changes in the human kidney of different races Gerontologia 17 87–97 Occurrence Handle5093734

    PubMed  Google Scholar 

  118. L Bax Y Fraaf Particlevan der AJ Rabelink et al. (2003) ArticleTitleInfluence of atherosclerosis on age-related changes in renal size and function Eur J Clin Invest 22 IssueID1 34–40 Occurrence Handle10.1046/j.1365-2362.2003.01091.x

    Article  Google Scholar 

  119. W DeLeon A Garcia PI. DeJesus (1933) ArticleTitleNormal weight of visceral organs in adult Filipinos Philip J Sci 52 111–127

    Google Scholar 

  120. MSF McLachlan P. Wasserman (1981) ArticleTitleChanges in size and distensibity of the aging kidney Br J Radiol 54 488–491 Occurrence Handle7237026

    PubMed  Google Scholar 

  121. GJ Griffiths KB Robinson GO Cartwright MS. McLachlan (1976) ArticleTitleLoss of renal tissue in the elderly Br J Radiol 49 111–117 Occurrence Handle938827

    PubMed  Google Scholar 

  122. I Ishikawa Z Onouchi Y Saito et al. (1981) ArticleTitleRenal cortex visualization and analysis of dynamic CT curves of the kidney J Comput Asist Tomogra 5 695–701

    Google Scholar 

  123. T Takeda A Imada A Horiuchi et al. (1996) ArticleTitleAge related changes in morphological studies in rat and human kidney Mippon Jinzo Gakkai Shi 38 IssueID12 555–562

    Google Scholar 

  124. N Gourtsoyiannis P Prassopoulos D Cavouras N. Pantelidis (1990) ArticleTitleThe thickness of the renal parenchyma decreases with age: a CT study of 360 patients Am J Roentgenol 155 IssueID3 541–544

    Google Scholar 

  125. JC Aschinberg O Koskimies J Bernstein et al. (1978) ArticleTitleThe influence of age on the response to renal parenchymal loss Yale J Biol Med 51 IssueID3 341–345 Occurrence Handle735156

    PubMed  Google Scholar 

  126. Burkhardt H, Hahn T, Gladisch R. Is kidney size a useful predictor of renal function in the elderly? Clin Nephrol 2993; 59(6): 415–422.

  127. A. Piepsz (2001) ArticleTitleNew renal scarring and age Nucl Med Commun 22 IssueID12 1273–1275 Occurrence Handle10.1097/00006231-200112000-00001 Occurrence Handle11711896

    Article  PubMed  Google Scholar 

  128. BL Kasiske AJ. Umen (1986) ArticleTitleThe influence of age, sex, race and body habitus on kidney weight in humans Arch Pathol 110 44–60

    Google Scholar 

  129. JR. Oliver (1952) Urinary System AI Lansing (Eds) Cowdry’s Problems of Ageing EditionNumber3 Williams and Wilkins Co Baltimore 631–650

    Google Scholar 

  130. B Kappel S. Olsen (1980) ArticleTitleCortical interstitial tissue and sclerosed glomeruli in the normal kidney, related to age and sex. A quantitative study Virchows Arch A 387 271–277

    Google Scholar 

  131. MSF McLachlan JC Guthrie CK Anderson MJ. Fulker (1977) ArticleTitleVascular and glomerular changes in the aging kidney J Path 121 65–78 Occurrence Handle10.1002/path.1711210202 Occurrence Handle874633

    Article  PubMed  Google Scholar 

  132. Bolton WK, Sturgill BC. In: Johnson JE, ed. Ultrastructure of the Aging Kidney. From Aging and Cell Structure, Vol. 1. Jr. Plenum Publishing Co., 1981: 215–250.

  133. BM. Wagner (1987) ArticleTitleRenal pathology and aging Human Pathol 18 IssueID7 659–660

    Google Scholar 

  134. C Baylis R. Schmidt (1996) ArticleTitleThe aging glomerulus Semin Nephrol 16 IssueID4 265–276 Occurrence Handle8829265

    PubMed  Google Scholar 

  135. RB Nagle PW Kohnen RE Bulger et al. (1969) ArticleTitleUltrastructure of human renal obsolescent glomeruli Lab Invest 21 IssueID6 519–526 Occurrence Handle4187808

    PubMed  Google Scholar 

  136. MW Steffes J Barbosa JM Basgen et al. (1983) ArticleTitleQuantitative glomerular morphology of the normal human kidney Lab Invest 49 IssueID1 82–86 Occurrence Handle6865334

    PubMed  Google Scholar 

  137. P Cortes X Zhao F Dumler et al. (1992) ArticleTitleAge-related changes in glomerular volume and hydroxyproline content in rat and human J Am Soc Nephrol 2 IssueID12 1716–1725 Occurrence Handle1498277

    PubMed  Google Scholar 

  138. S Anderson BM. Brenner (1986) ArticleTitleEffects of aging on the renal glomerulus Am J Med 80 IssueID3 435–442 Occurrence Handle10.1016/0002-9343(86)90718-7 Occurrence Handle3513560

    Article  PubMed  Google Scholar 

  139. IS Rantala HJ Helin JT Mustonen T. Reunala (1997) ArticleTitleAge-related appearance of amyloid P component in human renal glomeruli Nephron 77 IssueID4 399–403 Occurrence Handle9434060

    PubMed  Google Scholar 

  140. MS Dunnill W. Halley (1973) ArticleTitleSome observations on the quantitative anatomy of the kidney J Pathol 110 IssueID2 113–121 Occurrence Handle10.1002/path.1711100202 Occurrence Handle4125872

    Article  PubMed  Google Scholar 

  141. BL. Kasiske (1987) ArticleTitleRelationship between vascular disease and age-associated changes in the human kidney Kid Intern 31 1154–1159

    Google Scholar 

  142. Hughson M. Personal Communication, 3/7/03.

  143. J Neugarten G Gallo S Sibiger B. Kasiske (1999) ArticleTitleGlomerulosclerosis in aging humans is not influenced by gender Am J Kid Dis 34 IssueID6 884–888 Occurrence Handle10561145

    PubMed  Google Scholar 

  144. M Li KM Nicholls GJ. Becker (2002) ArticleTitleGlomerular size and global glomerulosclerosis in normal Caucasian donor kidneys: effects of aging and gender J. Nephrol 15 IssueID6 614–619 Occurrence Handle12495273

    PubMed  Google Scholar 

  145. C Kaplan B Pasternack H Shah G. Gallo (1975) ArticleTitleAge-related incidence of sclerotic glomeruli in human kidneys Am J Path 80 IssueID2 227–234 Occurrence Handle51591

    PubMed  Google Scholar 

  146. C Marcantoni M Li-Jun C Federspiel A. Fogo (2002) ArticleTitleHypertensive nephrosclerosis in African Americans versus Caucasians Kid Intern 62 IssueID1 172–180 Occurrence Handle10.1046/j.1523-1755.2002.00420.x

    Article  Google Scholar 

  147. P. Kincaid-Smith (1991) ArticleTitleAge-related glomerular sclerosis: baseline values in Hong Kong Pathology 23 IssueID3 275

    Google Scholar 

  148. J Neugarten B Basiske SR Silbiger JR. Nyengaard (2002) ArticleTitleEffects of sex on renal structure Nephron 90 139–144 Occurrence Handle10.1159/000049033 Occurrence Handle11818696

    Article  PubMed  Google Scholar 

  149. IW Gibson TT Downie IA More GB. Lindop (1996) ArticleTitleAtubular glomeruli and glomerular cysts – a possible pathways for nephron loss in the human kidney? J Pathol 179 IssueID4 421–426 Occurrence Handle10.1002/(SICI)1096-9896(199608)179:4<421::AID-PATH616>3.3.CO;2-V Occurrence Handle8869291

    Article  PubMed  Google Scholar 

  150. VK. Goyal (1982) ArticleTitleChanges with age in the human kidney Exp Gerontol 17 IssueID5 321–331 Occurrence Handle10.1016/0531-5565(82)90032-8 Occurrence Handle7169092

    Article  PubMed  Google Scholar 

  151. KM Newbold A Sandison AJ. Howie (1992) ArticleTitleComparison of size of juxtamedullary and outer cortical glomeruli in normal adult kidney Virchows Arch A Pathol Anat Histopathol 420 IssueID2 127–129 Occurrence Handle1549901

    PubMed  Google Scholar 

  152. DR. Abrahamson (2003) ArticleTitleUnveiling Mesangial mysteries Kid Intern 64 363–364 Occurrence Handle10.1046/j.1523-1755.2003.00087.x

    Article  Google Scholar 

  153. JP Langeveld JH Veerkamp JM Trijbels et al. (1984) ArticleTitleChemical composition and solubility of human glomerular and tubular abasement membranes of adult and senescent men Int J Biochem 16 IssueID12 1255–1264 Occurrence Handle10.1016/0020-711X(84)90225-8 Occurrence Handle6530012

    Article  PubMed  Google Scholar 

  154. M Hughson AB Farris SuffixIII R Douglas-Denton et al. (2003) ArticleTitleGlomerular number and size in autopsy kidneys: The relationship to birth weight Kid Intern 63 2113–2122 Occurrence Handle10.1046/j.1523-1755.2003.00018.x

    Article  Google Scholar 

  155. JR Nyengaard TF. Bendtsen (1992) ArticleTitleGlomerular number and size in relation to age, kidney weight, and body surface in normal man Anat Rec 232 IssueID2 194–201 Occurrence Handle10.1002/ar.1092320205 Occurrence Handle1546799

    Article  PubMed  Google Scholar 

  156. G Keller G Zimmer G Mall et al. (2003) ArticleTitleNephron number in patients with primary hypertension New Eng J Med 348 IssueID2 101–108 Occurrence Handle10.1056/NEJMoa020549 Occurrence Handle12519920

    Article  PubMed  Google Scholar 

  157. WE Hoy M Rees E Kile et al. (1999) ArticleTitleA new dimension to the Barker hypothesis: low birthweight and susceptibility to renal disease Kid Intern 56 1072–1077 Occurrence Handle10.1046/j.1523-1755.1999.00633.x

    Article  Google Scholar 

  158. JR. Ingelfinger (2003) ArticleTitleIs microanatomy destiny (perspective) New Eng J Med 348 IssueID2 99–101 Occurrence Handle10.1056/NEJMp020168 Occurrence Handle12519919

    Article  PubMed  Google Scholar 

  159. WE Hoy RN Douglas-Denton M Hughson et al. (2003) ArticleTitleA stereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy Kid Intern 63 IssueIDS83 S31–S37 Occurrence Handle10.1046/j.1523-1755.63.s83.8.x

    Article  Google Scholar 

  160. Fogo A. Personal communication, 2003.

  161. RH. Heptinstall (1966) Pathology of the Kidney EditionNumber1 Little, Brown and Co Boston 126–129

    Google Scholar 

  162. R. Meadows (1978) Renal Histopathology, The Obsolescent Glomerulus and the Disappearance of glomeruli From Kidneys EditionNumber2 Oxford University Press Oxford 54

    Google Scholar 

  163. Verani R, Silva F, Hogg R and the Southwest Pediatric Nephrology Study group. A clinico-pathologic study of crescentic glomerulonephritis in 50 children. Kid Intern 1985; 27: 450–458.

    Google Scholar 

  164. Olson JL. In: Jennette C, Olson JL, Schwartz MM, Silva FG, eds. Progression of Renal Disease (Chapter 4), From Heptinstall’s Pathology of the Kidney. Philadelphia: Lippincott-Raven Pub, 1998: 137–168.

  165. HS Mackenzie MW taal VA Luycks BM. Brenner (2000) Adaptation to nephron loss BM Brenner (Eds) Brenner and Rector’s The Kidney. Saunders Philadelphia 1901–1910

    Google Scholar 

  166. C Kaplan B Pasternack H Shah G. Gallo (1975) ArticleTitleAge-related incidence of sclerotic glomeruli in human kidneys Am J Path 80 IssueID2 227–234 Occurrence Handle51591

    PubMed  Google Scholar 

  167. SM Smith WE Hoy L. Cobb (1989) ArticleTitleLow incidence of glomerulosclerosis in normal kidneys Arch Pathol Lab Med 118 1253–1255

    Google Scholar 

  168. A Remuzzi M Mazerska GN Gephardt et al. (1995) ArticleTitleThree-dimensional analysis of glomerular morphology in patients with subtotal nephrectomy Kid Intern 48 IssueID1 155–162

    Google Scholar 

  169. AJ Howie T Kizaki M Beaman et al. (1989) ArticleTitleDifferent types of segmental sclerosing glomerular lesions in six experimental models of proteinuria J Pathol 157 IssueID2 141–145 Occurrence Handle10.1002/path.1711570209 Occurrence Handle2921674

    Article  PubMed  Google Scholar 

  170. Gallo G. Personal Communication, 2003.

  171. BM. Brenner (1983) ArticleTitleNephrology forum: hemodynamically mediated glomerular injury and the progressive nature of renal disease Kid Intern 23 647–655

    Google Scholar 

  172. G Maschio L. Oldrizzi (2000) ArticleTitleIntroduction Progression of renal disease in the third millenium. Kid Intern 57 IssueIDS75 S1

    Google Scholar 

  173. KM Newbold A Sandison AJ. Howie (1992) ArticleTitleComparison of size of juxtamedullary and outer cortical glomeruli in normal adult kidney Virchows Arch A Pathol Anat Histopathol 420 127–129 Occurrence Handle1549901

    PubMed  Google Scholar 

  174. CL Pirani FG. Silva (1980) The glomerulus: current concepts G Remuzzi G Mecca G Gaetano Particlede (Eds) Hemostasis, Prostaglandins and Renal Disease. Raven Press NY 25–44

    Google Scholar 

  175. PF Faubert JG. Porush (1998) Renal Disease in the Elderly EditionNumber2 Anatomy and Physiology. Marcel Dekker Inc NY 7–10

    Google Scholar 

  176. RJ Schmidt WH Beierwaltes C. Baylis (2001) ArticleTitleEffects of aging and alterations in dietary sodium intake on total nitric oxide production Am J Kid Dis 37 IssueID5 900–908 Occurrence Handle11325670

    PubMed  Google Scholar 

  177. M Epstein NK. Hollenberg (1976) ArticleTitleAge as a determinant of renal sodium conservation in normal man J Lab Clin Med 87 411–417

    Google Scholar 

  178. PF Faubert JG. Porush (1998) Renal Disease in the Elderly EditionNumber2 Disorders of Water and Salt Metabolism. Marcel Dekker Inc NY 15–38

    Google Scholar 

  179. S Adler RD Lindeman MJ Yiengst et al. (1968) ArticleTitleEffect of acute acid loading on urinary acid exretion by the aging human kidney J Lab Clin Med 72 IssueID2 278–289 Occurrence Handle5671202

    PubMed  Google Scholar 

  180. PF Faubert JG. Porush (1998) Renal Disease in the Elderly. Acid–Base Disorders EditionNumber2 Marcel Dekker Inc NY 61–74

    Google Scholar 

  181. PF Faubert JG. Porush (1998) Renal Disease in the Elderly. Disorders of Calcium, Phosphorus, and Magnesium Metabolism EditionNumber2 Marcel Dekker Inc NY 75–128

    Google Scholar 

  182. PF Faubert JG. Porush (1998) Renal Disease in the Elderly. Disorders of Potassium Metabolism EditionNumber2 Marcel Dekker Inc NY 39–60

    Google Scholar 

  183. PF Faubert JG. Porush (1998) Renal Disease in the Elderly. Disorders of Calcium, Phosphorus, and Magnesium Metabolism EditionNumber2 Marcel Dekker Inc NY 75–128

    Google Scholar 

  184. RD Lindeman R. Goldman (1986) ArticleTitleAnatomic and physiologic age changes in the kidney Exp Gerontol 21 IssueID4–5 379–406 Occurrence Handle10.1016/0531-5565(86)90044-6 Occurrence Handle3545873

    Article  PubMed  Google Scholar 

  185. GE Striker LI Schainuck RE Cutler EP. Benditt (1970) ArticleTitleStructural–functional correlations in renal diseases. I. A method for assaying and classifying histopathologic changes in renal disease Human Pathol 1 615–630

    Google Scholar 

  186. LI Schainuck GE Striker RE Cutler EP. Benditt (1970) ArticleTitleStructural–functional correlations Hum Pathol 1 632–641

    Google Scholar 

  187. KA. Nath (1992) ArticleTitleTubulointerstitial changes as a major determinant in the progression of renal damage Am J Kidney Dis 20 1 Occurrence Handle1621674

    PubMed  Google Scholar 

  188. A Bohle S Mackensen-Haen H. Gise Particlevon (1987) ArticleTitleSignificance of tubulointerstitial changes in the renal cortex for the secretary function and concentration ability of the kidney: a morphometric contribution Am J Nehrol 7 421–433

    Google Scholar 

  189. G Eknoyan MA McDonald D Appel JD. Truong (1990) ArticleTitleChronic tubulo-interstitial nephritis: Correlation between structural and functional findings Kid Intern 38 736–743

    Google Scholar 

  190. T Nadasdy Z Laszik KE Blick et al. (1994) ArticleTitleTubular atrophy in the end-stage kidney: A lectin and immunohistochemical study Human Path 25 22–28 Occurrence Handle10.1016/0046-8177(94)90166-X

    Article  Google Scholar 

  191. KA. Hruska (2002) ArticleTitleNephrology forum: treatment of chronic tubulointerstitial disease: A new concept Kid Intern 61 IssueID5 1911–1922 Occurrence Handle10.1046/j.1523-1755.2002.00331.x

    Article  Google Scholar 

  192. E. MeguidEl Nahas (2003) ArticleTitlePlasticity of kidney cells: Role in kidney remodeling and scarring Kid Intern 64 1553–1563 Occurrence Handle10.1046/j.1523-1755.2003.00255.x

    Article  Google Scholar 

  193. S Mezzano J Egido B Rodriquez-Iturbe (2003) ArticleTitleThe Participation of the Tubulointerstitium in Hypertension and Progression of Renal Disease Kid Intern 86 IssueID10 S1 Occurrence Handle10.1046/j.1523-1755.64.s86.1.x

    Article  Google Scholar 

  194. Silva FG, D’Agati V, Nadasdy T, eds. Renal Biopsy Interpretation. Chapter one: Renal Biopsy: An Historical Perspective: by Dr. Conrad L. Pirani. NY: Churchill Livingstone, 1996: 1–19.

  195. Greenfeld Z, Baylis C. Aging and the renal circulation. In: Advances in Organ Biology, Vol. 9. JAI Press Inc., 2000: 255–274.

  196. PF Faubert JC. Porush (1998) Renal Disease in the Elderly. Vascular Disease of the Kidney EditionNumber2 Marcel Dekker Inc NY 397–409

    Google Scholar 

  197. A Ljungqvist C. Lagergren (1962) ArticleTitleNormal intrarenal arterial pattern in adult and aging human kidney A micro-angiographical and histological study. J Anat Lond 96 285–300

    Google Scholar 

  198. E Takazakura N Sawabu A Handa et al. (1972) ArticleTitleIntrarenal vascular changes with age and disease Kid Intern 2 IssueID4 224–230

    Google Scholar 

  199. S Takebayashia Y Kiyoshi S Hisano et al. (2001) ArticleTitleBenign nephrosclerosis: incidence, morphology and prognosis Clin Nephrol 55 IssueID5 349–356 Occurrence Handle11393379

    PubMed  Google Scholar 

  200. Aj Davidson LB Talner WM. Downs (1969) ArticleTitleA study of the angiographical appearance of the kidney in an aging normotensive population Radiology 92 975–983 Occurrence Handle5771840

    PubMed  Google Scholar 

  201. NK Holtenberg DF Adams HS Solomon et al. (1974) ArticleTitleSenescence and the renal vasculature in normal man Circ Res 34 309–316 Occurrence Handle4362036

    PubMed  Google Scholar 

  202. Olson JL. Hypertension: Essential and Secondary Forms. In: Jennette JC, Olson J, Schwartz MM, Silva FG, eds. Heptinstall’s Diseases of the Kidney. 5th edn., Chapter 21. 1988: 943–1000.

  203. Falk RJ, Jennette JC. Glomerular disease in the elderly. In: Jacobson HR, Striker GE, Klahr S, eds. The Principles and Practice of Nephrology, 2nd edn. St. Louis, 1995: 518–523.

  204. RE. Tracy (1992) ArticleTitleNephrosclerosis from childhood to old age, a viewpoint Geriatric Nephrol Urol 1 201–211 Occurrence Handle10.1007/BF00636328

    Article  Google Scholar 

  205. RE. Tracy (1988) ArticleTitleBlood pressure, nephrosclerosis, and age: autopsy findings from the Honolulu heart program Mod Pathol 1 IssueID6 420–427 Occurrence Handle3065780

    PubMed  Google Scholar 

  206. RE Tracy JP Strong WP Newman SuffixIII et al. (1996) ArticleTitleRenovasculopathies of nephrosclerosis in relation to atherosclerosis at ages 25 to 54 years Kid Intern 49 564–570

    Google Scholar 

  207. RE. Tracy (1999) ArticleTitleThe heterogeneity of vascular findings in the kidneys of patients with benign essential hypertension Nephrol Dialysis Transplant 14 1634–1639 Occurrence Handle10.1093/ndt/14.7.1634

    Article  Google Scholar 

  208. RE Tracy G Berenson W Wattigney TJ. Barrett (1990) ArticleTitleThe evolution of benign arterionephrosclerosis from age 6 to 70 years Am J Path 136 IssueID2 429–439 Occurrence Handle2305836

    PubMed  Google Scholar 

  209. RE Tracy TJ Heigle M. Velez-Duran (1989) ArticleTitleEvidence for the Failure of the Laplace Law as a sole explanation for wall thickening of arteries in hypertensive and aging normotensive kidneys Arch Pathol Lab Med 113 342–349 Occurrence Handle2705866

    PubMed  Google Scholar 

  210. RE Tracy GT Malcom MC Oalmann et al. (1992) ArticleTitleRenal microvascular features of hypertension in Japan, Guatemala, and the United States Arch Path Lab Med 116 50–55 Occurrence Handle1734833

    PubMed  Google Scholar 

  211. RE. Tracy (1996) ArticleTitleRenovasculopathies of hypertension and the rise of blood pressure with age in blacks and whites Seminars Nephrol 16 IssueID2 126–133

    Google Scholar 

  212. RE Tracy T. Ishii (2000) ArticleTitleHypertensive renovasculopathies and the rise of blood pressure with age in Japan and USA Intern Urol Nephrol 32 109–117 Occurrence Handle10.1023/A:1007119132063

    Article  Google Scholar 

  213. RE Tracy JL. Rios-Dalenz (1994) ArticleTitleRarity of hypertensive stigmata in aging renocortical arteries of Bolivians Virchows Archiv 424 307–314 Occurrence Handle10.1007/BF00194616 Occurrence Handle8186896

    Article  PubMed  Google Scholar 

  214. RE Tracy WP Newmann SuffixIII WA Wattigney et al. (1995) ArticleTitleHistologic features of atherosclerosis and hypertension from autopsies of young individuals in a defined geographic population: the Bogalusa heart study Atherosclerosis 116 163–179 Occurrence Handle10.1016/0021-9150(95)05525-2 Occurrence Handle7575772

    Article  PubMed  Google Scholar 

  215. RE Tracy G Mulvad HS Pederson et al. (1996) ArticleTitleBlood pressure in people in Greenland assessed by measuring renovasculopathies of hypertension at autopsy Am J Hypertension 9 560–565 Occurrence Handle10.1016/0895-7061(95)00440-8

    Article  Google Scholar 

  216. RE Tracy SY Bhandaru MC Oalmann et al. (1991) ArticleTitleBlood pressure and nephrosclerosis in black and white men and women aged 25 to 54 Mod Pathol 4 IssueID5 602–609 Occurrence Handle1758872

    PubMed  Google Scholar 

  217. RE. Tracy (2000) ArticleTitleRecent declines of hypertensive renovasculopathies in New Orleans Blacks Am J Hypertension 13 96–972

    Google Scholar 

  218. RE Tracy HAM. Rodriquez (1996) ArticleTitleRenovasculopathies of hypertension in Mexico City Arch Pathol Lab Med 120 261–266 Occurrence Handle8629901

    PubMed  Google Scholar 

  219. RE Tracy JM. Guileyardo (1999) ArticleTitleRenovasculopathies of hypertension in Hispanic residents of Dallas, Texas Arch Med Res 30 40–48 Occurrence Handle10.1016/S0188-0128(98)00003-7 Occurrence Handle10071424

    Article  PubMed  Google Scholar 

  220. RE Tracy GS Berenson L Cueto-Garcia et al. (1992) ArticleTitleNephrosclerosis and aortic atherosclerosis from age 6 to 70 years in the United States and Mexico Virchows Archiv A 420 479–488 Occurrence Handle10.1007/BF01600252

    Article  Google Scholar 

  221. RE Tracy DN Lanjewar KG Ghorpade et al. (1997) ArticleTitleRenovasculopathies in elderly normotensives of Bombay, India Geriatric Nephr Urol 7 101–109 Occurrence Handle10.1023/A:1008237409093

    Article  Google Scholar 

  222. RE Tracy D Parra W Eisaguirre RAT. Balanza (2002) ArticleTitleInfluence of arteriolar hyalinization on arterial intimal fibroplasia in the renal cortex of subjects in the United States, Peru, and Bolivia, applicable also to other populations Am J Hypertension 15 1064–1073 Occurrence Handle10.1016/S0895-7061(02)03084-4

    Article  Google Scholar 

  223. RE Tracy T. Ishii (2000) ArticleTitleWhat is “nephrosclerosis”? Lessons from the US, Japan, and Mexico Nephrol Dial Transplant 15 1357–1366 Occurrence Handle10.1093/ndt/15.9.1357 Occurrence Handle10978391

    Article  PubMed  Google Scholar 

  224. RE Tracy MA Guzman MC Oalmann et al. (1993) ArticleTitleNephrosclerosis in three cohorts of black and white mean born 1925 to 1944, 1934 to 1953, and 1943 to 1962 Am J Hypertension 6 IssueID3 Pt 1 185–192

    Google Scholar 

  225. RE Tracy D Parra W Eisaguirre RA. Torres Balanza (2002) ArticleTitleThe action of aging upon coronary intima and renal microvasculature in USA and Andes populations Mech Ageing Dev 123 IssueID4 327–339 Occurrence Handle10.1016/S0047-6374(01)00376-1 Occurrence Handle11744044

    Article  PubMed  Google Scholar 

  226. RE Tracy EO. Overll (1996) ArticleTitleArterioles of perfusion-fixed hypertensive and aged kidneys Arch Path 82 526–534

    Google Scholar 

  227. RE. Tracy (1992) ArticleTitleBlood pressure related separately to parenchymal fibrosis and vasculopathy of the kidney Am J Kid Dis 20 IssueID2 124–131 Occurrence Handle1496964

    PubMed  Google Scholar 

  228. RE Tracy M-V Duran T Heigle MC. Oalmann (1988) ArticleTitleTwo variants of nephrosclerosis separately related to age and blood pressure Am J Path 131 IssueID2 270–282 Occurrence Handle3358455

    PubMed  Google Scholar 

  229. RE. Tracy (1998) ArticleTitleHistologic characteristics of coronary aratery in relation to the renovasculopathies of hypertension Ann Diagnostic Path 2 IssueID3 159–166 Occurrence Handle10.1016/S1092-9134(98)80003-8

    Article  Google Scholar 

  230. Tracy RE. Personal communication, 7/2/03.

  231. Chandler B. Personal communication, 2003.

  232. F Volhard T. Fahr (1914) Die Brightische Nierenkrankheit Springer Berlin

    Google Scholar 

  233. A Fogo JA Breyer MC Smith et al. (1997) ArticleTitleAccuracy of the diagnosis of hypertensive nephrosclerosis in African Americans: A report from the African American study of Kidney Disease (AASK) Trial. AASK Pilot Study Investigators Kid Intern 51 IssueID1 244–252

    Google Scholar 

  234. GS Hill D Hedes J. Bariety (2003) ArticleTitleMorphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation Kid Intern 63 1027–1036 Occurrence Handle10.1046/j.1523-1755.2003.00831.x

    Article  Google Scholar 

  235. JL. Olson (2003) ArticleTitleHyaline arteriolosclerosis: New meaning for an old lesion ed Kid Intern 63 1162–1163 Occurrence Handle10.1046/j.1523-1755.2003.00844.x

    Article  Google Scholar 

  236. C Baylis B. Corman (1998) ArticleTitleThe aging kidney: insights from experimental studies J Am Soc Nephrol 9 IssueID4 699–709 Occurrence Handle9555673

    PubMed  Google Scholar 

  237. C Baylis M Fredericks J Leypoldt et al. (1988) ArticleTitleThe mechanisms of proteinuria in aging rats Mech Ageing Deve 45 IssueID2 111–126 Occurrence Handle10.1016/0047-6374(88)90101-7

    Article  Google Scholar 

  238. CK. Abrass (2000) ArticleTitleThe nature of chronic progressive nephropathy in aging rats Adv Ren Replace Ther 7 IssueID1 4–10 Occurrence Handle10672913

    PubMed  Google Scholar 

  239. RH Bell SuffixJr BA Borjesson PL Wolf et al. (1984) ArticleTitleQuantiatitve morphological studies of aging changes in the kidney of the Lewis rat Ren Physiol 7 IssueID3 176–184 Occurrence Handle6610904

    PubMed  Google Scholar 

  240. WK Bolton BC. Sturgill (1980) ArticleTitleSpontaneous glomerular sclerosis in aging Sprague–Dawley rats. II. Ultrastructural studies Am J Pathol 98 IssueID2 339–356 Occurrence Handle7355986

    PubMed  Google Scholar 

  241. B. Corman (1992) ArticleTitleNormal and pathological renal aging in animals Presse Med 21 IssueID26 1238–1245 Occurrence Handle1409479

    PubMed  Google Scholar 

  242. WG Couser MM. Stilmant (1975) ArticleTitleMesangial lesions and focal gloemrular sclerosis in the aging rat Lab Invest 33 IssueID5 491–501 Occurrence Handle127075

    PubMed  Google Scholar 

  243. RS Goldstein JB Tarloff JB. Hook (1988) ArticleTitleAge-related nephropathy in laboratory rats FASEB J 2 IssueID7 3341–2251

    Google Scholar 

  244. DP Haley RE. Bulger (1983) ArticleTitleThe aging male rat: structure and function of the kidney Am J Anat 167 IssueID1 1–13 Occurrence Handle10.1002/aja.1001670102 Occurrence Handle6869305

    Article  PubMed  Google Scholar 

  245. MP O’Donnell BL Kasiske L Faij WF. Keane (1985) ArticleTitleAge is a determinant of the glomerular morphologic and functional response to chronic nephron loss J Lab Clin Med 106 IssueID3 308–313 Occurrence Handle4031632

    PubMed  Google Scholar 

  246. RA Owen R. Heywood (1986) ArticleTitleAge-related variations in renal structure and function in Sprague–Dawley rats Toxicol Path 14 IssueID2 158–167

    Google Scholar 

  247. JF Reckelhoff L Samsell R Dey et al. (1992) ArticleTitleThe effect of aging on glomerular hemodynamics in the rat Am J Kidney Dis 20 IssueID1 70–75 Occurrence Handle1621681

    PubMed  Google Scholar 

  248. A Remuzzi S Puntorieri M Alfano et al. (1992) ArticleTitlePatholophysiologic implications of proteinuria in a rat model of progressive glomerular injury Lab Invest 67 IssueID5 572–579 Occurrence Handle1434536

    PubMed  Google Scholar 

  249. HJ Schurek J Panzer A Wiemeyer et al. (1982) ArticleTitleEffects of aging on the glomerular capillaries, blood pressure, and renal function in rats Contrib Nephrol 30 157–162 Occurrence Handle7116855

    PubMed  Google Scholar 

  250. M Hayashida BP Yu EJ Masoro et al. (1986) ArticleTitleAn electron microscopic examination of age-related changes in the rat kidney: The influence of diet Exp Gerontol 21 IssueID6 535–553 Occurrence Handle10.1016/0531-5565(86)90006-9 Occurrence Handle3556454

    Article  PubMed  Google Scholar 

  251. SE Thomas S Anderson KL Gordon et al. (1998) ArticleTitleTubulointerstitial disease in aging: Evidence for underlying peritubular capillary damage, a potential role for renal ischemia J Am Soc Nephrol 9 IssueID2 231–242 Occurrence Handle9527399

    PubMed  Google Scholar 

  252. T Takizawa I Takasaki H Shionoiri M. Ishii (1998) ArticleTitleProgression of glomerulosclerosis, renal hypertrophy, and an increased expression of fibronectin in the renal cortex associated with aging and salt-induced hypertension in Dahl salt-sensitive rats Life Sci 61 IssueID(16 1553–1558 Occurrence Handle10.1016/S0024-3205(97)00734-0

    Article  Google Scholar 

  253. N Gagliano B Arosio D Santambrogio et al. (2000) ArticleTitleAge-dependent expression of fibrosis-related genes and collagen deposition in rat kidney cortex J Gerontol A Biol Sci Med Sci 55 IssueID8 365–372

    Google Scholar 

  254. JM Kaufman R Hardy JP. Hayslett (1975) ArticleTitleAge-dependent characteristics of compensatory renal growth Kid Intern 8 IssueID1 21–26

    Google Scholar 

  255. RA Zager CE. Alpers (1989) ArticleTitleEffects of aging on expression of ischemic acute renal failure in rats Lab Invest 61 IssueID3 290–294 Occurrence Handle2770246

    PubMed  Google Scholar 

  256. JA Vega A Ricci F. Amenta (1990) ArticleTitleAge-dependent changes of the sympathetic innervation of the rat kidney Mech Ageing Dev 54 IssueID3 185–196 Occurrence Handle10.1016/0047-6374(90)90049-L Occurrence Handle2214889

    Article  PubMed  Google Scholar 

  257. R Napoleone E Bronzetti F. Amenta (1991) ArticleTitleEnzyme histolchemistry of aging rat kidney Mech Ageing Dev 61 IssueID2 187–195 Occurrence Handle10.1016/0047-6374(91)90016-S Occurrence Handle1824123

    Article  PubMed  Google Scholar 

  258. H Ikeda H Tauchi T. Sato (1985) ArticleTitleFine structural analysis of lipofuscin in various tissues of rats of different ages Mech Ageing Dev 33 IssueID1 77–93 Occurrence Handle10.1016/0047-6374(85)90110-1 Occurrence Handle4079478

    Article  PubMed  Google Scholar 

  259. DJ Schoeffner DA Warren S Muralidara et al. (1999) ArticleTitleOrgan weights and fat volume in rats as a function of strain and age J Toxicol Environ Health A 56 IssueID7 449–462 Occurrence Handle10.1080/009841099157917 Occurrence Handle10201633

    Article  PubMed  Google Scholar 

  260. JE Gray MJ Zwieten Particlevan CF. Hollander (1982) ArticleTitleEarly light microscopic changes in chronic progressive nephrosis in several strains of aging laboratory rats J Gerontol 37 IssueID2 142–150 Occurrence Handle7056999

    PubMed  Google Scholar 

  261. K. Hirokawa (1975) ArticleTitleCharacterization of age-associated kidney disease in Wistar rats Mech Ageing Dev 4 IssueID3–4 301–316 Occurrence Handle10.1016/0047-6374(75)90031-7 Occurrence Handle127895

    Article  PubMed  Google Scholar 

  262. B Corman J Pratz P. Poujeol (1987) ArticleTitleChanges in anatomy, glomerular filtration, and solute excretion in aging rat kidneys Am J Physiol 248 IssueID3 Pt2 R282–R287

    Google Scholar 

  263. GF McDermott A Ingram J Scholey et al. (1996) ArticleTitleGlomerular dysfunction in the aging Fischer 344 rat is associated with excessive growth and normal mesangial cell function J Gerontol A Biol Sci Med Sci 51 IssueID2 M80–M85 Occurrence Handle8612108

    PubMed  Google Scholar 

  264. R Cardani T. Zavanella (2000) ArticleTitleAge-related cell proliferation and apoptosis in the kidney of male Fischer 344 rats with observations on a spontaneous tubular cell adenoma Toxicol Pathol 28 IssueID6 802–806 Occurrence Handle11127294

    PubMed  Google Scholar 

  265. N Marcussen JR Nyengaard S. Christensen (1994) ArticleTitleCompensatory growth of glomeruli is accomplished by an increasing number of glomerular capillaries Lab Invest 70 IssueID6 868–874 Occurrence Handle8015291

    PubMed  Google Scholar 

  266. BA Olson JR Day NJ. Laping (1999) ArticleTitleAge-related expression of renal thrombospondin 1 mRNA in F344 rats: Resemblance to diabetes-induced expression in obese Zucker rats Pharmacology 58 IssueID4 200–208 Occurrence Handle10.1159/000028282 Occurrence Handle10077739

    Article  PubMed  Google Scholar 

  267. J Chevalier C Masurier S Lavaud et al. (1995) ArticleTitleApproach of cellular mechanisms of glomerulosclerosis in a model of accelerated aging in the obese Zucker rat C R Seances Soc biol Fil 189 IssueID6 987–1007 Occurrence Handle8763029

    PubMed  Google Scholar 

  268. MJ Black Y Wang JF. Bertram (2002) ArticleTitleNephron endowment and renal filtration surface area in young spontaneously hypertensive rats Kidney Blood Press Res 25 IssueID1 20–26 Occurrence Handle10.1159/000049431 Occurrence Handle11834873

    Article  PubMed  Google Scholar 

  269. WG Couser MM. Stilmant (1976) ArticleTitleThe immunopathology of the aging rat kidney J Gerontol 31 IssueID1 13–22 Occurrence Handle1104703

    PubMed  Google Scholar 

  270. A Chkhotua Z Shapira A Tovar et al. (2001) ArticleTitleCellular senescence: A new marker of kidney function recovery after ischemic injury in rats Transplant Proc 33 IssueID6 2910–2115 Occurrence Handle10.1016/S0041-1345(01)02248-5 Occurrence Handle11543787

    Article  PubMed  Google Scholar 

  271. S Takeshita M Hosokawa M Irino et al. (1982) ArticleTitleSpontaneous age-associated amyloidosis in senescence-accelerated mouse (SAM) Mech Ageing Dev 20 IssueID1 13–23 Occurrence Handle10.1016/0047-6374(82)90070-7 Occurrence Handle7176700

    Article  PubMed  Google Scholar 

  272. RB Ashman JM Papadimitrious A. Fulurija (1999) ArticleTitleAcute susceptibility of aged mice to infection with Candida albicans J Med Micrbiol 48 IssueID12 1085–1102

    Google Scholar 

  273. LA Cullen-McEwen MM Kett J Dowling et al. (2003) ArticleTitleNephron number, renal function and arterial pressure in aged GDNF heterozygous mice Hypertension 41 IssueID2 335–340 Occurrence Handle10.1161/01.HYP.0000050961.70182.56 Occurrence Handle12574104

    Article  PubMed  Google Scholar 

  274. I Davies AP Fothringham BE. Faragher (1989) ArticleTitleAge-associated changes in the kidney of the laboratory mouse Age Ageing 18 IssueID2 127–133 Occurrence Handle2729008

    PubMed  Google Scholar 

  275. S Goto R Takahashi S Araki H. Nakamoto (2002) ArticleTitleDietary restriction initiated in late adulthood can reverse age-related alterations of protein and protein metabolism Ann N Y Acad Sci 969 50–56

    Google Scholar 

  276. J Han M Hosokawa M Umezawa et al. (1998) ArticleTitleAge-related changes in blood pressure in the senescence-accelerated mouse (SAM): aged SAMP1 mice manifest hypertensive vascular disease Lab Anim Sci 48 IssueID3 256–263 Occurrence Handle10090025

    PubMed  Google Scholar 

  277. J Hung A. Richardson (1993) ArticleTitleThe effect of aging on the genetic expression of renin by mouse kidney Aging (Milano) 5 IssueID3 193–198

    Google Scholar 

  278. C Lichtig J Levy D Gershon AZ. Reznick (1989) ArticleTitleEffect of exercise on the kidney of aging mice Isr J Med Sci 25 IssueID7 376–381 Occurrence Handle2759836

    PubMed  Google Scholar 

  279. C Lichtig J Levy D Gershon AZ. Reznick (1987) ArticleTitleEffect of aging and exercise on the kidney Anatomic and morphological studies. Gerontology 33 IssueID1 40–48

    Google Scholar 

  280. EP Peten A Garcia-Perez Y. Terada et al. (1992) Am J Physiol 263 IssueID5 Pt 2 F951–F957 Occurrence Handle1443183

    PubMed  Google Scholar 

  281. K Radnerath DH Li E. Randerath (1990) ArticleTitleAge-related DNA modification (I-compounds): modulation by physiological and pathological processes Mutat Res 238 IssueID3 245–253 Occurrence Handle2188122

    PubMed  Google Scholar 

  282. HR Warner F. Sierra (2003) ArticleTitleModels of accelerated ageing can be informative about the molecular mechanisms of ageing and/or age-related pathology Mech Ageing Dev 124 IssueID5 581–587 Occurrence Handle10.1016/S0047-6374(03)00008-3 Occurrence Handle12735898

    Article  PubMed  Google Scholar 

  283. W Yumara N Sugino R Nagasawa et al. (1989) ArticleTitleAge-associated changes in renal glomeruli of mice Exp Gerontol 24 IssueID3 237–249 Occurrence Handle10.1016/0531-5565(89)90015-6 Occurrence Handle2731581

    Article  PubMed  Google Scholar 

  284. E Nishida J Yamanouchi S Ogata et al. (1996) ArticleTitleAge-related histochemical and ultrastructural changes in renal glomerular mesangium of APA hamsters Exp Anim 45 IssueID4 339–345 Occurrence Handle10.1538/expanim.45.339 Occurrence Handle8902497

    Article  PubMed  Google Scholar 

  285. DR Finco SA Brown WA Crowell et al. (1994) ArticleTitleEffects of aging and dietary protein intake on uninephrectomized geriatric dogs Am J Vet Res 55 IssueID9 1282–1290 Occurrence Handle7802397

    PubMed  Google Scholar 

  286. L-J Ma AB. Fogo (2003) ArticleTitleModel of robust induction of glomerulosclerosis in mice: importance of genetic background Kid Intern 64 350–355 Occurrence Handle10.1046/j.1523-1755.2003.00058.x

    Article  Google Scholar 

  287. P Cortes Z Zhao F Dimler et al. (1992) ArticleTitleAge-related changes in glomerular volume and hydroxyproline content in rat and humans J Am Soc Nephrol 2 IssueID12 1716–1725 Occurrence Handle1498277

    PubMed  Google Scholar 

  288. C Baylis K Engels A Hymel LG. Navar (1997) ArticleTitlePlasma renin activity and metabolic clearance rate of angiotensin II in the unstressed aging rat Mech Ageing Dev 97 163–171 Occurrence Handle10.1016/S0047-6374(97)00053-5 Occurrence Handle9226634

    Article  PubMed  Google Scholar 

  289. C. Baylis (1993) ArticleTitleRenal responses to acute angiotensin II inhibition and administered angiotensin II in the aging, conscious, chronically catheterized rat Am J Kid Dis 22 IssueID6 842–850 Occurrence Handle8250031

    PubMed  Google Scholar 

  290. C Baylis K Engels WH. Beierwaltes (1998) ArticleTitleBeta-adrenoceptor-stimulated renin release is blunted in old rats J Am Soc Nephrol 9 1318–1320 Occurrence Handle9644645

    PubMed  Google Scholar 

  291. C Baylis M Fredericks C Wilson et al. (1990) ArticleTitleRenal vasodilatory response to intravenous glycine in the aging rat kidney Am J Kid Dis 15 IssueID3 244–251 Occurrence Handle2305764

    PubMed  Google Scholar 

  292. A Erdely Z Greenfeld L Wagner C. Baylis (2003) ArticleTitleSexual dimorphism in the aging kidney: effects on injury and nitric oxide system Kid Intern 63 1021–1028 Occurrence Handle10.1046/j.1523-1755.2003.00830.x

    Article  Google Scholar 

  293. Z Greenfeld K Engels L Samsell C. Baylis (1998) ArticleTitleThe role of endothelin in the age dependent increase in renal vascular resistance in the rat kidney Mech Ageing Dev 101 145–152 Occurrence Handle10.1016/S0047-6374(97)00171-1 Occurrence Handle9593320

    Article  PubMed  Google Scholar 

  294. X-Z Zhang C Qiu C. Baylis (1997) ArticleTitleSensitivity of the segmental renal arterioles to angiotensin II in the aging rat Mech Ageing Dev 97 183–192 Occurrence Handle10.1016/S0047-6374(97)00055-9 Occurrence Handle9226636

    Article  PubMed  Google Scholar 

  295. S Masilamani X-Z Zhang C. Baylis (1998) ArticleTitleBlunted pressure natriuretic response in the old rat: participation of the renal nerves Am J Kid Dis 32 IssueID4 605–610 Occurrence Handle9774122

    PubMed  Google Scholar 

  296. EM Tolbert J Weisstuch J Feiner LD. Dworkin (2000) ArticleTitleOnset of glomerular hypertension with aging precedes injury in the spontaneously hypertensive rat Am J Physiol Renal Physiol 278 IssueID5 F839–F846 Occurrence Handle10807597

    PubMed  Google Scholar 

  297. B Corman MB Barrault C Klinger et al. (1995) ArticleTitleRenin gene expression in the aging kidney: Effect of sodium restriction Mech Ageing Dev 84 IssueID1 1–13 Occurrence Handle10.1016/0047-6374(95)01630-I Occurrence Handle8719773

    Article  PubMed  Google Scholar 

  298. W Goettsch T Lattmann K Amann et al. (2001) ArticleTitleIncreased expression of endothelin-1 and inducible nitric oxide synthase isoform II in aging arteries in vivo: Implications for atherosclerosis Biochem Biophy Res Commun 280 IssueID3 908–913 Occurrence Handle10.1006/bbrc.2000.4180

    Article  Google Scholar 

  299. ND Vazari XQ Wang ZN Ni et al. (2002) ArticleTitleEffects of aging and AT-1 receptor blockade on NO synthase expression and renal function in SHR Biochem Biopshy Acta 1592 IssueID2 153–161

    Google Scholar 

  300. Y Xiong LW Yuan HW Deng et al. (2001) ArticleTitleElevated serum endogenous inhibitor of nitric oxide synthase and endothelial dysfunction in aged rats Clin Exp Pharmacol Physiol 28 IssueID10 842–847 Occurrence Handle10.1046/j.1440-1681.2001.03533.x Occurrence Handle11553026

    Article  PubMed  Google Scholar 

  301. C Hill AM Lateef K Engels et al. (1997) ArticleTitleBasal and stimulated nitric oxide in control of kidney function in the aging rat Am J Physiol 272 R17747–R17753

    Google Scholar 

  302. JF Reckelhoff RD Manning SuffixJr. (1993) ArticleTitleRole of endothelium-derived nitric oxide in control of renal microvasculature in aging male rats Am J Physiol 265 IssueID5 Pt 2 R1126–R1131 Occurrence Handle8238614

    PubMed  Google Scholar 

  303. C Baylis CB. Wilson (1989) ArticleTitleSex and the single kidney A J Kid Dis 13 IssueID4 290–298

    Google Scholar 

  304. C. Baylis (1994) ArticleTitleAge-dependent glomerular damage in the rat: Dissociation between glomerular injury and both glomerular hypertension and hypertrophy J Clin Invest 94 1823–1829 Occurrence Handle7962527

    PubMed  Google Scholar 

  305. A Tanaka M Kyokuwa T Mori S. Kawashima (1995) ArticleTitleAcceleration of renal dysfunction with ageing by the use of androgen in Wistar/Tw rats In Vivo 9 IssueID5 495–502 Occurrence Handle8900929

    PubMed  Google Scholar 

  306. V Francois D Heudes J Bariety et al. (1996) ArticleTitleGlomerular capillary network of cortical nephrons is reducted in male but not in female aging rats Mech Ageing Dev 91 IssueID1 11–22 Occurrence Handle10.1016/0047-6374(96)01773-3 Occurrence Handle8910256

    Article  PubMed  Google Scholar 

  307. M Mune H Otani S. Yukawa (2002) ArticleTitleEffects of antioxidants on kidney disease Mech Ageing Dev 123 IssueID8 1041–1046 Occurrence Handle10.1016/S0047-6374(01)00387-6 Occurrence Handle12044953

    Article  PubMed  Google Scholar 

  308. K Kitani C Minami T Yamamoto et al. (2002) ArticleTitlePharmacological interventions in aging and age-associated disorders: Potentials of propargylamines for human use Ann NY Acad Sci 959 295–397 Occurrence Handle11976204

    PubMed  Google Scholar 

  309. MP Ruiz-Torres RJ Bosch F O’Valle et al. (1998) ArticleTitleAge-related increase in expression of TGF-beta l in the rat kidney: relationship to morphologic changes J Am Soc Nephrol 9 IssueID5 782–791 Occurrence Handle9596075

    PubMed  Google Scholar 

  310. M. Bendayan (1998) ArticleTitleImmunocytochemical detection of advance glycated end products in rat renal tissue as a function of age and diabetes Kid Intern 54 IssueID2 438–447 Occurrence Handle10.1046/j.1523-1755.1998.00030.x

    Article  Google Scholar 

  311. MF Cohen FN. Ziyadeh (1996) ArticleTitleRole of Amadori-modified nonenzymatically glycated serum proteins in the pathogenesis of diabetic nephropathy J Am Soc Neprhol 7 IssueID2 183–190

    Google Scholar 

  312. A Heidland K Sebekova R. Schinzel (2001) ArticleTitleAdvanced glycation end products and the progressive course of renal disease Am J Kid Dis 38 IssueID4Suppl1 S100–S106 Occurrence Handle11576932

    PubMed  Google Scholar 

  313. M Hamelin C Borot-Laloi B Friguet H. Bakala (2003) ArticleTitleIncreased level of glycoxidation product N(varepsilon)-(carboxymethyl) lysine in rat serum and urine proteins with aging: link with glycoxidative damage accumulation in kidney Arch Biochem Biophys 411 IssueID2 215–222 Occurrence Handle10.1016/S0003-9861(02)00735-X Occurrence Handle12623070

    Article  PubMed  Google Scholar 

  314. CR. Seances (1995) ArticleTitleEffects of glycation process on the macromolecular structure of the glomerular basement membranes and on the glomerular functions in aging and diabetes mellitus [article in French] Soc Biol Fil 189 IssueID6 967–985

    Google Scholar 

  315. A Audige B Dick BM Frey et al. (2002) ArticleTitleGlucocorticoids and 11 beta-hydroxysteroid dehydrogenase type 2 gene expression in the agind kidney Eur J Clin Invest 32 IssueID6 411–420 Occurrence Handle10.1046/j.1365-2362.2002.01003.x Occurrence Handle12059986

    Article  PubMed  Google Scholar 

  316. HS Ranhotra R. Sharma (2001) ArticleTitleModulation of hepatic and renal glucocorticoid receptors during aging of mice Biogerontology 2 IssueID4 245–251 Occurrence Handle11868899

    PubMed  Google Scholar 

  317. S Combet N Geffroy V Berthonaud et al. (2003) ArticleTitleCorection of age-related polyuria by dDAVP: Molecular anlysis of aquaporins and urea transporters Am J Physiol Renal Physiol 284 IssueID1 F199–F208 Occurrence Handle12388383

    PubMed  Google Scholar 

  318. L Preisser L Teillet S Aliotti et al. (2000) ArticleTitleDownregulation of aquaporinj-2 and −3 in aging kidney is independent of V(2) vasopressin receptor Am J Physiol Renal Physiol 270 IssueID1 F144–F152

    Google Scholar 

  319. Sands J et al. Aquaporin articles.

  320. KL Swenson JM Sands JD Jacobs CD. Sladek (1997) ArticleTitleEffect of aging on vasopressin and aquaporin responses to dehydration in Fischer 344-Brown-Norway F1 rats Am Physiol Soc 273 IssueID1Pt2 R35–R40

    Google Scholar 

  321. J Catudioc-Vallero JM Sands JD Klein et al. (2000) ArticleTitleEffect of Age and Testosterone on the Vasopressin and Aquaporin Responses to Dehydration in Fischer 344/Brown-Norway F1 Rats J Gerontol: Biological Sciences 55 IssueID(1 B26–B34

    Google Scholar 

  322. CT Liang J Barnes H Hanai MA. Levine (1993) ArticleTitleDecrease in Gs protein expression may impair adenylate cyclase activation in old kidneys Am J Physiol 264 IssueID5Pt2 F770–F773 Occurrence Handle8498529

    PubMed  Google Scholar 

  323. CA Lopez JR Hoyer PD Wilson et al. (1993) ArticleTitleHeterogeneity of osteopontin expression among nephrons and enhanced expression in sclerotic glomeruli Lab Invest 69 IssueID3 355–363 Occurrence Handle8377476

    PubMed  Google Scholar 

  324. HJ Armbrecht M Boltz R Strong et al. (1989) ArticleTitleExpression of calbindin-D decreases with age in intestine and kidney Endocrinology 125 IssueID6 2950–2956 Occurrence Handle2583050

    PubMed  Google Scholar 

  325. A Battisti P Barili F Ferrante et al. (1996) ArticleTitleEffect of treatment with L-deprenyl on age-dependent microanatomical changes in the rat kidney Mech Ageing De 89 IssueID1 1–10 Occurrence Handle10.1016/0047-6374(96)01730-7

    Article  Google Scholar 

  326. DH Kang S Anderson YG Kim et al. (2001) ArticleTitleImpaired angiogenesis in the aging kidney: Vascular endothelial growth factor and thrmmbospondin-1 in renal disease Am J Kid Dis 37 IssueID3 601–611 Occurrence Handle11228186

    PubMed  Google Scholar 

  327. LJ Ma S Makamura JS Whitsitt et al. (2000) ArticleTitleRegression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1 Kid Intern 58 IssueID6 2425–2436 Occurrence Handle10.1046/j.1523-1755.2000.00426.x

    Article  Google Scholar 

  328. K Yamamoto T Shimokawa H Yi et al. (2002) ArticleTitleAging accelerates endotoxin-induced thrombosis: Increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging Am J Pathol 161 IssueID5 1805–1814 Occurrence Handle12414527

    PubMed  Google Scholar 

  329. K Yamamoto DJ Loskutoff H. Saito (1998) ArticleTitleRenal expression of fibrinolytic genes and tissue factor in a murine model of renal disease as a function of age Semin Thromb Hemost 24 IssueID3 261–268 Occurrence Handle9701458

    PubMed  Google Scholar 

  330. Z Greenfeld K Engels L Samsell C. Baylis (2001) ArticleTitleAcute neutral endopeptidase inhibition is natriuetic in old rats Mech Ageing Dev 122 1293–1301 Occurrence Handle10.1016/S0047-6374(01)00264-0 Occurrence Handle11438120

    Article  PubMed  Google Scholar 

  331. D DePriest C Zimmermann C. Baylis (1990) ArticleTitleRenal effects of administered atrial natriuretic peptide in the conscious aging rat Life Sci 46 785–792 Occurrence Handle10.1016/0024-3205(90)90066-Z Occurrence Handle2138690

    Article  PubMed  Google Scholar 

  332. P Arivazhagan K Ramanathan C. Pannerselvam (2001) ArticleTitleEffects of DL-alpha-lipoic acid on mitochrondrial enzymes in aged rats Chem Biol Interact 138 IssueID2 189–198 Occurrence Handle10.1016/S0009-2797(01)00268-X Occurrence Handle11672700

    Article  PubMed  Google Scholar 

  333. P Arivazhagan K Ramanathan C. Panneerselvam (2001) ArticleTitleEffect of DL-alpha-lipoic acid on glutathione metabolic enzymes in aged rats Exp Gerontol 37 IssueIDJ(1 81–87 Occurrence Handle10.1016/S0531-5565(01)00147-4 Occurrence Handle11738149

    Article  PubMed  Google Scholar 

  334. HM Brown-Borg SG. Rakoczy (2000) ArticleTitleCatalse expression in delayed and premature aging mouse models Exp Gerontol 35 IssueID2 199–212 Occurrence Handle10.1016/S0531-5565(00)00079-6 Occurrence Handle10767579

    Article  PubMed  Google Scholar 

  335. G Casadevall C Piera J Setoain J. Queralt (1995) ArticleTitleAge-dependent enzymuria, proteinuria and changes in renal blood flow and glomerular filtration rates in rats Mech Ageing Dev 82 IssueID1 51–60 Occurrence Handle10.1016/0047-6374(95)01598-T Occurrence Handle7475356

    Article  PubMed  Google Scholar 

  336. Al Cessac M Perichon J Schaeverbeke H. Bakala (1993) ArticleTitleAge-related changes in albumin binding by renal brush-border membrane vesicles Mech Ageing Dev 70 IssueID1–2 139–148 Occurrence Handle10.1016/0047-6374(93)90065-Y Occurrence Handle8231285

    Article  PubMed  Google Scholar 

  337. JM Dhahbi PL Mote J Wingo et al. (1999) ArticleTitleCalories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes Am J Physiol 277 IssueID2Pt1 E352–E360 Occurrence Handle10444432

    PubMed  Google Scholar 

  338. M Hacham S Argov RM White et al. (2002) ArticleTitleDifferent patterns of interleukin-l alpha and interleukin-l beta expression in organs of normal young and old mice Eur Cytokine Netw 13 IssueID1 55–65 Occurrence Handle11956021

    PubMed  Google Scholar 

  339. M Helenius M Hanninen Sk Lehtinen A. Salminen (1996) ArticleTitleChanges associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B Biochem J 318 IssueIDPt2 603–608 Occurrence Handle8809053

    PubMed  Google Scholar 

  340. JA Johnson MJ Beckman A Pansini-Porta et al. (1995) ArticleTitleAge and gender effects on 1,2,5-dihydroxyvitamin D3-regulated gene expression Exp Gerontol 30 IssueID6 631–643 Occurrence Handle10.1016/0531-5565(95)00014-3 Occurrence Handle8867530

    Article  PubMed  Google Scholar 

  341. HJ Kim KW Kim BP Yu HY. Chung (2000) ArticleTitleThe effect of age on cycloxygenase-2 gene expression: NF-kappa B activation and IkappaB alpha degradation Free Radic Biol Med 28 IssueID5 683–692 Occurrence Handle10754263

    PubMed  Google Scholar 

  342. R Liu J. Choi (2000) ArticleTitleAge-associated decline in gamma-glutaylcysteine synthetase gene expression in rats Free Radic Biol Med 28 IssueID4 566–574 Occurrence Handle10.1016/S0891-5849(99)00269-5 Occurrence Handle10719238

    Article  PubMed  Google Scholar 

  343. R Iida T Yasuda M Aoyama et al. (2000) ArticleTitleAge-related changes of gene expression in mouse kidney: flourescence differential display-PCR analyses Mech Ageing Dev 113 IssueID2 135–144 Occurrence Handle10.1016/S0047-6374(99)00104-9 Occurrence Handle10708260

    Article  PubMed  Google Scholar 

  344. R Martin G Ritzl C Mozet et al. (2002) ArticleTitleEffect of age and hypoxia/reoxygenation on mRNA expression of antioxidative enzymes in rat liver and kidneys Exp Gerontol 37 IssueID12 1481–1487 Occurrence Handle10.1016/S0531-5565(02)00168-7 Occurrence Handle12559417

    Article  PubMed  Google Scholar 

  345. T Mizuntani S Nakashima Y. Nozawa (1998) ArticleTitleChanges in the expression of protein kinase C (PKC), phospholipases C (PLC) and D (PLD) isoforms in spleen, brain and kidney of the aged rate: RT-PCR and Western Blot analysis Mech Ageing Dev 105 IssueID1–2 151–172 Occurrence Handle10.1016/S0047-6374(98)00094-3 Occurrence Handle9922125

    Article  PubMed  Google Scholar 

  346. M Nakano Y Ito K Kohtani et al. (1985) ArticleTitleAge-related change in brush borders of rat kidney cortex Mech Ageing Dev 33 IssueID1 95–102 Occurrence Handle10.1016/0047-6374(85)90111-3 Occurrence Handle4079479

    Article  PubMed  Google Scholar 

  347. HT Nguyen AA Thomson BA Kogan et al. (1999) ArticleTitleExpression of the Wnt gene family during late nephrogenesis and complete ureteral obstruction Lab Invest 79 IssueID6 647–658 Occurrence Handle10378507

    PubMed  Google Scholar 

  348. Y Ogawa M Nishikawa N tyoda et al. (1999) ArticleTitleAge- and sex-related changes in type-1 iodothyronine deiodinase messenger ribonucleic acid in rat liver and kidney Horm Metab Res 31 IssueID5 295–299 Occurrence Handle10422723

    PubMed  Google Scholar 

  349. J Pelletier RR Desrosiers R. Beliveau (1996) ArticleTitleAge-related changes in carboyl methylation of proteins in the kidney Mech Ageing Dev 86 IssueID2 115–135 Occurrence Handle10.1016/0047-6374(95)01682-1 Occurrence Handle8852932

    Article  PubMed  Google Scholar 

  350. I Petropoulous J Mary M Perichon B. Friguet (2001) ArticleTitleRat peptide methionine sulphoxide reductase: Cloning of the cDNA, and down-regulation of gene exprssion and enzyme activity during aging Biochem J 355 IssueIDPt3 819–825 Occurrence Handle11311146

    PubMed  Google Scholar 

  351. CK Abrass MJ Adcox GJ. Raugi (1885) ArticleTitleAge-associated changes in renal extracellular matrix Am J Path 146 IssueID3 742–752

    Google Scholar 

  352. JF Reckelhoff C. Baylis (1992) ArticleTitleProximal tubular metalloprotease activity is decreased in the senescent rat kidney Life Sci 50 959–963 Occurrence Handle10.1016/0024-3205(92)90174-N Occurrence Handle1548979

    Article  PubMed  Google Scholar 

  353. JF Reckelhoff C. Baylis (1993) ArticleTitleGlomerular metalloprotease activity in the aging rat kidney: Inverse correlation with injury J Am Soc Nephr 3 1835–1838

    Google Scholar 

  354. ME Rosenberg R Girton D Finkel et al. (2002) ArticleTitleApolioprotein J/clusterin prevents a progressive glomerulopathy of aging Mol Cell Biol 22 IssueID6 1893–1902 Occurrence Handle10.1128/MCB.22.6.1893-1902.2002 Occurrence Handle11865066

    Article  PubMed  Google Scholar 

  355. P Ruiz-Torres M Gonzalez-0Rubio FJ Lucio-Cazana et al. (1994) ArticleTitleReactive oxygen species and platelet-activating factor synthesis in age-related glomerulosclerosis J Lab Clin Med 124 IssueID4 468–469 Occurrence Handle7930869

    PubMed  Google Scholar 

  356. B Velasco L Cacicedo E Melian et al. (2001) ArticleTitleSensitivity to exogenous GH and resversibility of the reduced IGF-1 gene expression in aging rats Eur J Endocrinol 145 IssueID1 73–85 Occurrence Handle10.1530/eje.0.1450073 Occurrence Handle11415855

    Article  PubMed  Google Scholar 

  357. R Vranckz L Savu N Lambert et al. (1995) ArticleTitlePlasma proteins as biomarkers of the aging process Am J Physiol 268 IssueID2Pt2 R536–R548 Occurrence Handle7532377

    PubMed  Google Scholar 

  358. SK Mistry Z Greenfeld SM Morris SuffixJr C. Baylis (2002) ArticleTitleThe “intestinal-renal” arginine biosynthetic axis in the aging rat Mech Ageing Dev 123 IssueID8 1159–1165 Occurrence Handle10.1016/S0047-6374(02)00003-9 Occurrence Handle12044965

    Article  PubMed  Google Scholar 

  359. F Inserra LA Romano EM deCavanagh et al. (1996) ArticleTitleRenal interstitial sclerosis in aging: effects of enalapril and nifedipine J Am Soc Nephrol 7 IssueID(5 676–680 Occurrence Handle8738801

    PubMed  Google Scholar 

  360. PH. Lane (1997) ArticleTitleAge of onset of streptozotocin diabetes determines the renal structural response in the rat Pediatr Res 41 IssueID6 912–915 Occurrence Handle9167208

    PubMed  Google Scholar 

  361. B Halloran P Uden QY Duh et al. (2002) ArticleTitleParathyroid gland volume increases with postmaturational aging in the rat Am J Physiol Endocrinol Metab 282 IssueID3 E557–E563 Occurrence Handle11832357

    PubMed  Google Scholar 

  362. K Stewart P Wilson Hc Wilson et al. (2001) ArticleTitleThy 1 glomerulonephitis induced in young Lewis rats accelerates age-related glomerulosclerosis Nephron 88 IssueID1 57–64 Occurrence Handle10.1159/000045960 Occurrence Handle11340352

    Article  PubMed  Google Scholar 

  363. T Sato H. Tauchi (1982) ArticleTitleAge changes of mitochondria of rat kidney Mech Ageing Dev 20 IssueID2 111–126 Occurrence Handle10.1016/0047-6374(82)90063-X Occurrence Handle7176706

    Article  PubMed  Google Scholar 

  364. K Anzai C Imazato S. Goto (1983) ArticleTitlemRNA population in the liver, kidney and brain of young and senescent mice: Analysis of in vitro translation products Mech Ageing Dev 23 IssueID2 137–150 Occurrence Handle10.1016/0047-6374(83)90063-5 Occurrence Handle6140330

    Article  PubMed  Google Scholar 

  365. JE Johnson CH Barrows SuffixJr. (1980) ArticleTitleEffects of age and dietary restriction on the kidney glomeruli of mice: Observations by scanning electron microscopy Anat Rec 196 IssueID2 145–151 Occurrence Handle10.1002/ar.1091960204 Occurrence Handle7416508

    Article  PubMed  Google Scholar 

  366. MH Lu WG Hinson An Turturro et al. (1991) ArticleTitleCell cycle analysis in bone marrow and kidney tissues of dietary restricted rats Mech Ageing Dev 59 IssueID1–2 111–121 Occurrence Handle10.1016/0047-6374(91)90077-D Occurrence Handle1890875

    Article  PubMed  Google Scholar 

  367. LA Cullen-MeEwen MM Kett J Dowling et al. (2003) ArticleTitleNephron number, renal function, and arterial pressure in aged GDNF heterozygous mice Hypertension 41 IssueID2 335–340 Occurrence Handle10.1161/01.HYP.0000050961.70182.56 Occurrence Handle12574104

    Article  PubMed  Google Scholar 

  368. RE Tracy LK. Johnson (1994) ArticleTitleAging of a class of arteries in various mammalian species in relation to the life span Gerontology 40 291–297 Occurrence Handle7867958

    PubMed  Google Scholar 

  369. AM Cusamano NL Bodkin BC Hansen et al. (2002) ArticleTitleGlomerular hypertrophy is associated with hyperinsulinemia and precedes overt diabetes in aging rhesus monkeys Am J Kid Dis 40 IssueID5 1075–1084 Occurrence Handle10.1053/ajkd.2002.36348 Occurrence Handle12407654

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fred G. Silva.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Silva, F.G. The Aging Kidney: A Review – Part I. Int Urol Nephrol 37, 185–205 (2005). https://doi.org/10.1007/s11255-004-0873-6

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11255-004-0873-6

Keywords

Navigation