Abstract
This study was conducted to investigate the efficacy of ivermectin (IVM), doramectin (DRM), and moxidectin (MXD) against Toxocara vitulorum in calves. In the study, 20 calves naturally infected with T. vitulorum were divided into four groups: three different treatment groups (n = 5) and one positive control (n = 5). The animals in each group received either IVM (Baymec®, Bayer), DRM (Dectomax®, Pfizer), or MXD (Cydectin®, Fort Dodge) by subcutaneous injection at a single dose of 0.2 mg/kg. Fecal egg counts were performed on all animals on days 0, 2, 4, 8, 12, and 16 post-treatment. In conclusion, IVM, DRM, and MXD significantly reduced the fecal egg counts on day 8 post-treatment (99.90%, 98.77%, and 99.57%, respectively). After the 12th day, IVM, DRM, and MXD were found to be 100% effective. There was no significant difference in efficacy between the three treatment groups at any of the sampling dates (P > 0.05). No side effects associated with nervous, respiratory, and gastrointestinal systems were observed. This is the first study to evaluate the comparative efficacy of subcutaneous administration of ivermectin, doramectin, and moxidectin against naturally infected T. vitulorum in calves.
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References
Avcioglu, H., Balkaya, I., 2011. Efficacy of eprinomectin against Toxocara vitulorum in calves, Tropical Animal Health and Production, 43(2), 283–286
Davila, G., Irsik, M., Greiner, E.C., 2010. Toxocara vitulorum in beef calves in North Central Florida, Veterinary Parasitology, 168, 261–3
Henderson, C.F., Tilton, E.W., 1955. Tests with acaricides against the brown wheat mite, Journal of Economic Entomology, 48, 157–161
Kassai T 1999. Veterinary Helminthology. Butterworth-Heinemann, Boston, MS, pp. 102–103
Lanusse, C., Lifschitz, A., Virkel, G., Alvarez, L., Sánchez, S., Sutra, J.F., Galtier, P., Alvinerie, M., 1997. Comparative plasma disposition kinetics of ivermectin, moxidectin and doramectin in cattle, Journal of Veterinary Pharmacology and Therapeutics, 20, 91–9
Mahieu, M., Naves, M., 2008. Incidence of Toxocara vitulorum in creole Calves of Guadeloupe, Tropical Animal Health and Production, 40, 243–8.
Ndong, T.B., Kane, Y., Ba, M.A., Sane, I., Sutra, J.F., Alvinerie, M. 2005. Pharmacokinetics of ivermectin in zebu Gobra (Bos indicus), Veterinary Parasitology, 128, 169–73
Roberts, J.A., 1989a. The extraparasitic life cycle of Toxocara vitulorum in the village environment of Sri Lanka, Veterinary Research Communications, 13, 377–388
Roberts, J.A., 1989b. Toxocara vitulorum: treatment based on the duration of the infectivity of buffalo cows (Bubalus bubalis) for their calves, Journal of Veterinary Pharmacology and Therapeutics, 12, 5–13
Roberts, J.A., Fernando, S.T., Sivanathan, S., 1990. Toxocara vitulorum in the milk of buffalo (Bubalus bubalis) cows, Research in Veterinary Science, 49, 289–291
Soulsby, E.J.L., 1982. Helminths, arthropods and protozoa of domesticated animals, 7th ed. Bailliere Tindall, London, pp 150–152
Srivastava, A.K., Sharma, D.N. 1981. Studies on the occurrence, clinical features and pathomorphological aspects of ascariasis in buffalo calves, Veterinary Research Journal, 4, 160–162
Starke, W.A., Machado, R.Z., Bechara, G.H., Zocoller M.C., 1996. Skin hypersensitivity tests in buffaloes parasitized with Toxocara vitulorum, Veterinary Parasitology, 63, 283–290
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Avcioglu, H., Balkaya, I. A comparison of the efficacy of subcutaneously administered ivermectin, doramectin, and moxidectin against naturally infected Toxocara vitulorum in calves. Trop Anim Health Prod 43, 1097–1099 (2011). https://doi.org/10.1007/s11250-011-9807-3
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DOI: https://doi.org/10.1007/s11250-011-9807-3