Skip to main content

Advertisement

SpringerLink
Log in

Comparative therapeutic effect of moxidectin, doramectin and ivermectin on psoroptes mites infestation in buffalo (Bubalus bubalis)

  • Original Paper
  • Published:
Tropical Animal Health and Production Aims and scope Submit manuscript

Abstract

The aim of the present study was to carry out comparative therapeutic effect of moxidectin pour on, doramectin and ivermectin on psoroptes infestation in buffalo. A total of 318 buffalo in 77 small scale herds suspected to have mange mites were examined clinically and parasitologically. Fifty-three (16.66%) buffalo in 25 herds were recorded to be infested; 51 (16.35%) with psoroptic mites, and two (0.31%) with chorioptic mites. Buffalo with psoroptic mites were randomly allocated into three groups (17 buffalo each). First group was treated with moxidectin pour on at a dose rate of 0.5 mg kg-1. The second group received doramectin (200 µg kg-1 twice subcutaneously, 14 days apart). The third group received ivermectin (200 µg kg-1 twice subcutaneously, 14 days apart). Adjunct to each drug, deltamethrin was applied to the surrounding environment twice at a two week interval. Treatment outcomes of 51 buffalo with psoroptic mites showed that moxidectin pour on and doramectin had a significant higher effect on mite count reduction (MANOVA, P < 0.01; Walks, Lambda, P < 0.01) and clinical sum scores (MANOVA, P < 0.05; Walks, Lambda, P < 0.05) compared with injectible ivermectin. On clinical level, the number of clinically recovered buffalo in moxidectin and doramectin treated groups was significantly (P < 0.05) higher than that of ivermectin treated group. The result of the present study indicated that psoroptic mites are the main cause of mange in buffalo in Lower Egypt. This is the first report that describes the effect of moxidectin in buffalo. Moxidectin is a good alternative and easily applied drug for treatment of psoroptes infestation in buffalo.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Arends, J.J., Skogerboen, T.I., Ritzhaupt, I.K., 1999. Persistent efficacy of doramectin and ivermectin against experimental infestations of Sarcoptic scabiei in swine. Veterinary Parasitology, 82, 71-79. doi:10.1016/S0304-4017(99)00003-5

    Article  CAS  PubMed  Google Scholar 

  • Azam, M., Siddiqui, M.M., Habib, G., 2002. Prevalence of parasitic infection in buffalo calves in Khadagzai, District Dir. Pakistan Veterinary Journal, 22, 87-90.

    Google Scholar 

  • Bala, A., Rath, S.S., 2006. Comparative efficacy of doramectin, ivermectin and amitraz against sarcoptic mange in buffalo calves. Indian Veterinary Journal, 83, 75-76.

    Google Scholar 

  • Barber, S., Bowles, V., Lespine, A., Alvinerie, M., 2003.The comparative serum disposition kinetics of subcutaneous administration of doramectin, ivermectin and moxidectin in the Australian Merino sheep. Journal of Veterinary Pharmacology and Therapeutics, 26, 343-348. doi:10.1046/j.1365-2885.2003.00526.x

    Article  CAS  PubMed  Google Scholar 

  • Berriatua, E., French, N.P., Broster, C.E., Morgan, K.L., Wall, R., 2001. Effect of infestation with psoroptes ovis on the nocturnal rubbing and lying behavior of housed sheep. Applied Animal Behaviour, 71, 43-55. doi:10.1016/S0168-1591(00)00166-0

    Article  Google Scholar 

  • Bowman, D., 1995. Georgis’ Parasitology for Veterinarians, 6th ed. Saunders, Philadelphia, 430 pp.

    Google Scholar 

  • Brien, D.J.O., 1999. Treatment of psoroptic mange with reference to epidemiology and history. Veterinary Parasitology, 30, 77-185.

    Google Scholar 

  • Bukva, V., Vítovec, J., Moucha, P., Váhala, J., 1984. Demodicosis of an African buffalo (Syncerus caffer caffer) in captivity. Zentralbl Veterinarmed B, 31, 627-633.

    CAS  PubMed  Google Scholar 

  • Cadiergues, M.C., Laguerre, C., Roques, M., Franc, M., 2004. Evaluation of the bioequivalence of two formulations of deltamethrin for treatment of sheep with psoroptic mange. American Journal of Veterinary Research, 65, 151-154. doi:10.2460/ajvr.2004.65.151

    Article  CAS  PubMed  Google Scholar 

  • Cernea, C., Cernea, M., 2006. Establishing the causal factors in the development of psoroptic mange in buffalo from S.C.D.C.B. Sercaia, Brasov District. Lucrari Stiintifice, 40, 349-354.

    Google Scholar 

  • Currie, B.J., Harumal, P., McKinnon, M., Walton, S.F., 2004. First documentation of in vivo and in vitro ivermectin resistance in Sarcoptes scabiei. Clinical Infectious Diseases, 39, 8-12. doi:10.1086/421776

    Article  Google Scholar 

  • Dräger, N., Paine, G.D., 1980. Demodicosis in African Buffalo (Syncerus caffer caffer) in Botswana. Journal of Wildlife Diseases, 16, 521-524.

    PubMed  Google Scholar 

  • Dupuy, J., Sutra, J.F., Alvinerie, M., Rinaldi, L., Veneziano, V., Mezzino, L., Pennacchio, S., Cringoli, G., 2008. Plasma and milk kinetic of eprinomectin and moxidectin in lactating water buffaloes (Bubalus bubalis). Veterinary Parasitology, 157, 284-90. doi:10.1016/j.vetpar.2008.07.027

    Article  CAS  PubMed  Google Scholar 

  • Fthenakis, G.C., Papadopoulos, E., Himonas, C., Leontides, C., Kritas, S., Papatsas, J., 2000. Efficacy of moxidectin against sarcoptic mange and effects on milk yield of ewes and growth of lambs. Veterinary Parasitology, 87, 207–216 doi:10.1016/S0304-4017(99)00182-X

    Article  CAS  PubMed  Google Scholar 

  • Genchi, C., Alvinerie, M., Forbes, A., Bonfanti, M., Genchi, M., Vandoni, S., Innocenti, M., Sgoifo Rossi, C.A., 2008. Comparative evaluation of two ivermectin injectable formulations against psoroptic mange in feedlot cattle. Veterinary Parasitology, 158, 110-116. doi:10.1016/j.vetpar.2008.08.007

    Article  CAS  PubMed  Google Scholar 

  • Gill, B.S., Singh, J., Gill, B.S., Singh, A., Khehra, S.S., Rai, A., Hussain, O., 1989. Efficacy of ivermectin against mange and gastrointestinal nematodes of buffalo (Bubalus bubalis). Veterinary Parasitolology, 31, 141-147. doi:10.1016/0304-4017(89)90029-0

    Article  CAS  Google Scholar 

  • Greaves, N.W., Wall, P.D., 1996. Pathophysiology of itching. Lancet, 348, 938-940. doi:10.1016/S0140-6736(96)04328-0

    Article  CAS  PubMed  Google Scholar 

  • Jabeen, F., Ahmed, N., Chaudhy, M.A., Joved, I., 1998. Epidemiology and treatment of sarcoptic mange in buffalo calves around Lahore. Pakistan Veterinary Journal, 181, 39-42.

    Google Scholar 

  • Jones, J., Jenkins, T., Webb, L., Davies, A., Bates, P., 2008. Psoroptic mange in cattle in south Wales. Veterinary Record, 162, 460.

    PubMed  Google Scholar 

  • Logan, N.B., Weatherle, A.J., Phillips, F.E., Wilkins, C.P., Shanks, D.J., 1993. Spectrum of activity of doramectin against cattle mites and lice. Veterinary Parasitology, 49, 67-73. doi:10.1016/0304-4017(93)90225-C

    Article  CAS  PubMed  Google Scholar 

  • Lonneux, J. F, Losson, B., 1992. Field efficacy of injectable and pour-on moxidectin in cattle naturally infested with Psoroptes ovis (Acarina: Psoroptidae). Veterinary Parasitology, 45, 147-152. doi:10.1016/0304-4017(92)90037-A

    Article  CAS  PubMed  Google Scholar 

  • Losson, B., Lonneux, J. F., 1996. Field efficacy of moxidectin 0.5% pour-on against Chorioptes bovis, Damalinia bovis, Linognathus vituli and Psoroptes ovis in naturally infected cattle. Veterinary Parasitology, 63, 119-130. doi:10.1016/0304-4017(95)00882-9

  • Losson, B., Lonneux, J.F., 1993. Field efficacy of injectable moxidectin in cattle naturally infested with Chorioptes bovis and Sarcoptes scabiei. Veterinary Parasitology, 51, 113-21. doi:10.1016/0304-4017(93)90202-X

    Article  CAS  PubMed  Google Scholar 

  • Matthes, H.F., Busch, A., Drobigk, U., Hiepe, Th., 1993. Efficacy of moxidectin against Sarcoptes bovis in experimentally infected calves. In: Proceedings of the 14th International Conference of the World Association for the Advancement of Veterinary Parasitology, August 1993, Cambridge, UK, 264 pp.

  • Mavi, P. S., Singh, N.K., Rath, S.S., 2006. Comparative efficacy of ivermectin and closantel against psoroptic mange in buffalo calves. Indian Veterinary Journal, 83, 216-217.

    Google Scholar 

  • Mitra, J., Bardhan, G., Basu, A.K., 2005. Efficacy of oral ivermectin against sarcoptic mange in buffalo calves. Indian Veterinary Journal, 82, 666-667.

    Google Scholar 

  • Nooruddin, M., Gill, B.S., Singh, J., Singh, K.B., 1986. Prevalence of clinical sarcoptic and psoroptic mange in buffaloes of the Punjab. Buffalo Journal, 2, 81-86.

    Google Scholar 

  • Osman, S.A., Hanafy, A., Amer, S.E., 2006. Clinical and therapeutic studies on mange in horses. Veterinary Parasitology, 141, 191-5. doi:10.1016/j.vetpar.2006.04.039

    Article  CAS  PubMed  Google Scholar 

  • Patel, J.S., Patel, P.R., Panchasara, H.H., Brahmaxatri, K.G., 2003. Comparative efficacy of some drugs against sarcoptic mange in buffalo calves. Indian Journal of Veterinary Medicine, 23, 90-92.

    Google Scholar 

  • Purohit, G.N., Vyas, S.K., Yadav, S.B.S., 1997. Efficacy of ivermectin treatment for sarcoptic mange in surti buffalo calves. Indian Veterinary Journal, 74, 689-690.

    Google Scholar 

  • Qadoos, A., Khan, M.N., Hayat, C.S., Iqbal, Z., Ali, M.R., 1995. Studies on the prevalence and taxonomy of mites of cattle in Faisalabad (Pakistan). Pakistan Veterinary Journal, 15, 89-90.

    Google Scholar 

  • Ramprabhu, R.A., Mayilvahanam S., Nambi, A.P., Sethupandian P., Periasamy D. 2001. Concurrent sarcoptic and psoroptic mange infestation in Bubalus bubalis - a case report. Veterinarski Arhiv, 71, 53-56.

    Google Scholar 

  • Shalaby, S.I., Gupta, N., 2000. Clinical studies on zoonotic diseases in Major Cairo (Egypt) and a review on zoonotic potential in India. Journal of Parasitology and Applied Animal Biology, 9, 17-24.

    Google Scholar 

  • Sievers, G., Ramirez, C., Gonzalez, S., 1993. Evaluation of moxidectin for the treatment of sarcoptic mange in calves. Archivos de Medicina Veterinaria, 25, 193-197.

    Google Scholar 

  • Sutherland, I.A., Damsteegt, A., Miller, C.M., Leathwick, D.M., 2008. Multiple species of nematodes resistant to ivermectin and a benzimidazole-levamisole combination on a sheep farm in New Zealand. New Zealand Veterinary Journal, 56, 67-70.

    CAS  PubMed  Google Scholar 

  • Taylor, S.M., 1999. Sheep scab-environmental considerations of treatment with doramectin. Veterinary Parasitology, 83, 309-317. doi:10.1016/S0304-4017(99)00067-9

    Article  CAS  PubMed  Google Scholar 

  • Tikaram, S.M., Ruprah, N.S., 1986. Incidence of sarcoptic mange in buffaloes in India. Tropical Animal Health and Production, 18, 86-90. doi:10.1007/BF02359718

    Article  CAS  PubMed  Google Scholar 

  • Zaitoun, A.M., Ali, H.S., Ahmed, L.S., Abu-Zeid, A. S.I. 1998. Field observations on buffaloe’s mange in Assiut governorate, Egypt. Assiut Veterinary Medical Journal, 39, 245-256.

    Google Scholar 

Download references

Acknowledgement

The authors would like to thank Fort Dodge Animal health, Japan for generous supply of moxidectin pour on.

Author information

Authors and Affiliations

  1. Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt

    Sabry A. El-Khodery

  2. Large Animal Medicine Research Unit, Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Nishi, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan

    Mitsu Ishii

  3. Department of Animal Medicine, Faculty of Veterinary Medicine, Kafr El-Sheikh University, Kafr El-Sheikh, 33516, Egypt

    Salama A. Osman & Magdy H. Al-Gaabary

Authors
  1. Sabry A. El-Khodery
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mitsu Ishii
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Salama A. Osman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Magdy H. Al-Gaabary
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Salama A. Osman.

Rights and permissions

Reprints and permissions

About this article

Cite this article

El-Khodery, S.A., Ishii, M., Osman, S.A. et al. Comparative therapeutic effect of moxidectin, doramectin and ivermectin on psoroptes mites infestation in buffalo (Bubalus bubalis). Trop Anim Health Prod 41, 1505–1511 (2009). https://doi.org/10.1007/s11250-009-9340-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11250-009-9340-9

Keywords

Search

Navigation