Abstract
New therapeutic bionic lubricants for artificial joint lubrication and the treatment of particle-induced osteolysis were developed. In this study, their tribological characteristics and mechanisms have been investigated. The tribological experimental results show that the therapeutic lubricants have the best anti-wear performance among the lubricants tested, such as hyaluronic acid (HA) and bovine serum. Some self-assembled membranes were found on the surfaces of the cups, which might contribute to the high lubrication performance of the therapeutic lubricants. The calculated film thickness of therapeutic lubricants is about 0.310 μm, which is still in the boundary lubrication region. The preliminary biological experiments show that therapeutic lubricants have good biocompatibility. It is necessary to do more experimental work in the future to investigate the formation of the membrane and the medical performance of the therapeutic bionic lubricants for better understanding of the effects of the undesired reactions induced by the wear debris.
Similar content being viewed by others
References
Amstutz, H.C., Campbell, P., Kossovsky, N.: Mechanism and clinical significance of wear debris induced osteo1ysis. C1in. Orthop. 276, 6–7 (1992)
Harris, W.H.: The problem is osteolysis . C1in. Orthop. 311, 46–53 (1995)
Wang, A., Essner, A., Schmidig, G.: The effect of lubricant composition on in vitro wear testing of polymeric acetabular components. J. Biomed. Mater. Res. Part B, Appl. Biomater. 68B, 45–52 (2004)
McGee, M.A., Howie, D.W., Neale, S.D., Haynes, D.R., Pearcy, M.J.: The role of polyethylene wear in joint replacement failure. Proc. Inst. Mech. Eng. Part H Eng. Med. 211(1), 65–72 (1997)
Lewis, G.: Polyethylene wear in total hip and knee arthroplastics. J. Biomed. Mater. Res. 38(1), 55–75 (1997)
Widmer, M.R., Heuberger, M., Vörös, J., Spencer, N.D.: Influence of polymer surface chemistry on frictional properties under protein-lubrication conditions: implications for hip-implant design. Tribol. Lett. 10, 111–116 (2001)
Liang, H., Shi, B., Fairchild, A., Cale, T.: Applications of plasma coatings in artificial joints: an overview. Vacuum 73, 317–326 (2004)
Shi, B., Ajayi, O.O., Fenske, G., Erdemir, A., Liang, H.: Tribological performance of some alternative bearing materials for artificial joints. Wear 255, 1015–1021 (2003)
Stewart, T.D., Tipper, J.L., Insley, G., Streicher, R.M., Ingham, E., Fisher, J.: Long-term wear of ceramic matrix composite materials for hip prostheses under severe phase microseparation. J. Biomed. Mater. Res. Part B, Appl. Biomater. 66B, 567–573 (2003)
Saikko, V., Calonius, O., Keranen, J.: Effect of counterface roughness on the wear of conventional and crosslinked ultrahigh molecular weight polyethylene studied with a multi-directional motion pin-on-disk device. J. Biomed. Mater. Res. 57, 506–512 (2001)
Cawley, J., Metcalf, J.E.P., Jones, A.H., Band, T.J., Skupien, A.: A tribological study of cobalt chromium molybdenum alloys used in metal-on-metal resurfacing hip arthroplasty. Wear 255, 999–1006 (2003)
Tercic, D., Bozic, B.: The basis of the synovial fluid analysis. Clin. Chem. Lab. Med. 39, 1221–1126 (2001)
Brannan, S.R., Jerrard, D.A.: Synovial fluid analysis. Emerg. Med. 30, 331–339 (2006)
Ahlroos, T., Saikko, V.: Wear of prosthetic joint materials in various lubricants. Wear 211, 113–119 (1997)
Ishida, K., Okada, K., Hamada, Y.: Wear and bending strain characteristics of artificial hip joint with non-glued stem and UHMWPE femur. Precision Engineering 29, 396–403 (2005)
Yao, J.Q., Laurent, M.P., Johnson, T.S., Blanchard, C.R., Crowninshield, R.D.: The influences of lubricant and material on polymer/CoCr sliding friction. Wear 255, 780–784 (2003)
Zhang, J.H., Tao, D.H., Fu, S.F., Li, J., Zhao, Y.: Design of bionic lubrication system of artificial joints and study on the tribological performance of a synthetic synovial fluid. Mocaxue Xuebao/Tribology 23, 500–503 (2003)
Zhang, J.H., Su, S.H., Tao, D.H.: Tester for bio-artificial-joints and experimental study. Mocaxue Xuebao/Tribology 26, 32–35 (2006)
Costigan, P.A., Deluzio, K.J., Wyss, U.P.: Knee and hip kinetics during normal stair climbing. Gait Posture 16, 31–37 (2002)
Seireg, A., Arviter, R.J.: The prediction of muscular load sharing and joint forces in the lower extremities during walking. J. Biomech. 8, 89–102 (1975)
Su, S.H., Hua, Z.K., Zhang, J.H.: Design and mechanics simulation of bionic lubrication system of artificial joints. J. Bionic Eng. 3, 155–160 (2006)
Im, G.I., Qureshi, S.A., Kenney, J., Rubash, H.E., Shanbhag, A.S.: Osteoblast proliferation and maturation by bisphosphonates. Biomaterials 25, 4105–4115 (2004)
Mckellop, H.A., Campell, P., Amstutz, H.C., Sarmiento, A.: The origin of submicron polyethylene wear debris in total hip arthroplasty. Clin. Orthop. 311, 3–20 (1995)
Nijenbanning, G., Venner, C.H., Moes, H.: Film thickness in elasto-hydrodynamically lubricated elliptic contacts. Wear 176, 217–229 (1994)
Jalali-Vahid, D., Jagatia, M., Jin, Z.M., Dowson, D.: Prediction of lubricating film thickness in UHMWPE hip joint replacements. J. Biomech. 34, 261–266 (2001)
Wang, F.C., Jin, Z.M.: Elastohydrodynamic lubrication modelling of artificial hip joints under steady-state conditions. ASME J. Tribol. 127, 729–739 (2005)
Mabuchi, K., Obara, T., Ikegami, K., Yamaguchi, T., Kanayama, T.: Molecular weight independence of the effect of additive hyaluronic acid on the lubricating characteristics in synovial joints with experimental deterioration. Clin. Biomech. 14, 352–356 (1999)
Sawae, Y., Murakami, T., Chen, J.: Effect of synovia constituents on friction and wear of ultra-high molecular polyethylene sliding against prosthetic joint materials. Wear 216, 213–219 (1998)
Shanbhag, A.S., Hasselman, C.T., Rubash, H.E.: Inhibition of wear debris mediated osteolysis in a canine total hip arthroplasty model. Clin. Orthop. 344, 33–43 (1997)
Millett, P.J., Allen, M.J., Bostrom, M.P.: Effects of alendronate on particle-induced osteolysis in a rat model. J. Bone Joint Surg. 84, 236–249 (2002)
Venesmaa, P.K.: Alendronate reduces periprosthetic bone loss after uncemented primary total hip arthroplasty: a prospective randomized study. J. Bone Miner. Res. 16, 2126–2131 (2001)
Smith, E.J., McEvoy A., Little, D.G., Baldock, P.A., Eisman, J.A., Gardiner, E.M.: Transient retention of endochondral cartilaginous matrix with bisphosphonate treatment in a long-term rabbit model of distraction osteogenesis. J. Bone Miner. Res. 19, 1698–1705 (2004)
Little, D.G., Smith, N.C., Williamsm P.R., Briody, J.N., Bilston, L.E., Smith E.J., Gardiner, E.M., Cowell, C.T.: Zoledronic acid prevents osteopenia and increases bone strength in a rabbit model of distraction osteogenesis. J. Bone Miner. Res. 8, 1300–1307 (2003)
Saikko, V.: Effect of lubricant protein concentration on the wear of ultra-high molecular weight polyethylene sliding against a CoCr counterface. J. Tribol. 125, 638–642 (2003)
Jin, L., Yu, Y.X., Gao, G.H.: A molecular-thermodynamic model for the interactions between globular proteins in aqueous solutions: applications to bovine serum albumin (BSA), lysozyme, α-chymotrypsin, and immuno-gamma-globulins (IgG) solutions. J. Colloid. Interface. SCI 304, 77–83 (2006)
Haynes, C.A., Tamura, K., Korfer, H.R., Blanch, H.W., Prausnitz, J.M.: Thermodynamic properties of aqueous alphachymotrypsin solutions from membrane osmometry measurements. J. Phys. Chem. 96, 905–912 (1992)
Toshio, K., Gerard, A.A., Van, C.M., Kadoya, Y., Yamano, Y.: Constituents and pH changes in protein rich hyaluronan solution affect the biotribological properties of artificial articular joints. J. Biomech. 34, 1031–1037 (2001)
Acknowledgments
This work has been financially supported by the National Science Foundation of China through the grant number of 50105014, “Bionic Lubrication System of artificial joints.” The corresponding author, Dr. J.H. Zhang, would also like to acknowledge the financial support provided by the Science and Technology Committee of Shanghai under the grant number of 04 QMX1442 and partially support by Shanghai Leading Academic Discipline Project, Project Number: Y0102. The first author, Mr. Z.K. Hua, would like to acknowledge the financial support provided by the Graduate Innovation Fund of Shanghai University, Project Number: A.16-0109-07-002.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hua, Z.K., Su, S.H. & Zhang, J.H. Tribological Study on New Therapeutic Bionic Lubricants. Tribol Lett 28, 51–58 (2007). https://doi.org/10.1007/s11249-007-9247-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11249-007-9247-4