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Chiral phosphinites as efficient ligands for enantioselective Ru(II), Rh(I) and Ir(III)-catalyzed transfer hydrogenation reactions

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Abstract

Metal-catalyzed enantioselective transfer reduction of ketones to enantiomerically enriched chiral alcohols has recently attracted attention. Therefore, a series of methyl alkyl or alkyl/aryl ketones have been reduced by using Ru(II), Rh(I) and Ir(III) catalysts based on C 2-symmetric chiral ferrocenyl phosphinite ligands. The corresponding optically active secondary alcohols were obtained in excellent conversions and moderate-to-good enantioselectivities. The best results were obtained with an iridium catalyst, giving up to 98% conversion and 80% ee.

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Acknowledgements

Partial supports of this work by TUBİTAK (Project Number: 111T419) and Dicle University (Project Numbers: FEN.16.010 (NMR), DÜBAP FEN.15.021 and FEN.15.022) are gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Science Faculty, Dicle University, 21280, Diyarbakir, Turkey

    Akın Baysal, Nermin Meriç, Bünyamin Ak, Murat Aydemir & Feyyaz Durap

  2. Science and Technology Application and Research Center (SUBTAM), Siirt University, 56000, Siirt, Turkey

    Duygu Elma Karakaş

Authors
  1. Akın Baysal
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  2. Duygu Elma Karakaş
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  3. Nermin Meriç
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  4. Bünyamin Ak
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  5. Murat Aydemir
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  6. Feyyaz Durap
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Corresponding author

Correspondence to Murat Aydemir.

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Baysal, A., Elma Karakaş, D., Meriç, N. et al. Chiral phosphinites as efficient ligands for enantioselective Ru(II), Rh(I) and Ir(III)-catalyzed transfer hydrogenation reactions. Transit Met Chem 42, 365–372 (2017). https://doi.org/10.1007/s11243-017-0140-1

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