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Synthesis, crystal structure, DNA- and albumin-binding properties of a chromium(III) complex with 1,10-phenanthroline and a Schiff base derived from glycine

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Abstract

A new Cr(III) complex, [CrCl(sal-gly)phen]·0.5H2O (sal-gly = Schiff base derived from salicylaldehyde and l-glycine), has been synthesized and characterized by physicochemical methods. There are two independent complex molecules and a water molecule in each asymmetric unit. Each Cr(III) atom is six-coordinated in a distorted octahedral coordination environment. In the crystal, a 3D network is formed via intermolecular hydrogen bonds. The interactions between the Cr(III) complex and calf thymus DNA (CT-DNA) and Bovine serum albumin (BSA) have been studied by spectroscopic methods. The results show that the complex binds to CT-DNA in an intercalative mode, and it can also bind to BSA and produce conformational changes in the protein.

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Acknowledgments

This project was supported by the Shandong Provincial Natural Science Foundation, China (No.Y2004B02) and the Special-purpose Construction Project Foundation for “Taishan Scholar” of Shandong Province.

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Authors and Affiliations

  1. Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, No. 1, Hunan Road, Liaocheng, 252059, People’s Republic of China

    Hongyan Liu, Lianzhi Li, Qiong Guo & Jinghong Li

  2. Department of Material Science, Shandong Polytechnic Technician College, Liaocheng, 252027, People’s Republic of China

    Jianfang Dong

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  1. Hongyan Liu
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  2. Lianzhi Li
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  3. Qiong Guo
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Correspondence to Lianzhi Li.

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Liu, H., Li, L., Guo, Q. et al. Synthesis, crystal structure, DNA- and albumin-binding properties of a chromium(III) complex with 1,10-phenanthroline and a Schiff base derived from glycine. Transition Met Chem 38, 441–448 (2013). https://doi.org/10.1007/s11243-013-9709-5

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  • DOI: https://doi.org/10.1007/s11243-013-9709-5

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