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Synthesis, characterization and biological activity studies of octahedral nickel(II) complexes

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Abstract

Three nickel(II) complexes, namely [Ni(BH)3](H2O)(NO3)(ClO4) 1, [Ni(BH)2(NO3)2] 2 and [Ni(BH)(Tren)](ClO4)2 3 (BH = Benzoylhydrazine, Tren = Tris(2-aminoethyl)amine) have been synthesized and characterized by physico-chemical techniques. X-ray crystallographic analysis shows the nickel to be six-coordinated in these complexes. The complexes are efficient catalysts for the dismutation of superoxide in alkaline DMSO-NBT assays. The IC50 values are 74,108 and 105 μM for 1, 2 and 3, respectively.

Graphical Abstract

Three nickel(II) complexes with bidentate ligand viz.; [Ni(BH)3](NO3)(ClO4)(H2O) 1, [Ni(BH)2(NO3)2] 2 and [Ni(BH)(Tren)](ClO4)2 3 have been synthesized and characterized, including crystal structure, (Fig. 1) spectral characterization and electrochemical studies. X-ray crystallographic analysis shows the nickel to be six-coordinated mode in the respective complexes. The molecules of complexes 1 and 2 may stabilize in the crystal lattice due to the presence of π, π-interactions.

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References

  1. Ainscough EW, Brodie AM, Ranford JD, Waters JM (1995) Inorg Chim Acta 236:83

    Article  CAS  Google Scholar 

  2. Kocyigit KB, Rollas S (2002) II Farmaco 57:595

    Article  Google Scholar 

  3. Stroupe ME, DiDonato M, Tainer JA (2001) In: Messer Schmidt A, Huber R, Poulos R, Weighardt K (eds) Handbook of metalloproteins. Wiley, England

    Google Scholar 

  4. Chaudhary SB (1999) Biochemistry 38:3744

    Article  Google Scholar 

  5. Barondeaue DP (2004) Biochemistry 43:8038

    Article  Google Scholar 

  6. Youn HD, Kin EJ, Roe JH, Hah YC, Kang SO (1996) J Biochem 318:889

    CAS  Google Scholar 

  7. McCord JM (2002) Superoxide Dismutase 349:331

    Article  CAS  Google Scholar 

  8. Miller AF (2004) Cur Opin Chem Biol 8:162

    Article  CAS  Google Scholar 

  9. Sheldrick GM (2008) Acta Crystallogr, Sect. A, A64, 112–122

  10. Sheldrick GM (1997) Program for crystal structure solution and refinement. University of Goettingen, Goettingen

    Google Scholar 

  11. Patel RN, Singh N, Shukla KK, Chouhan UK, Niclós-Gutiérrez J, Castiñeiras A (2004) Inorg Chim Acta 357:2469

    Article  CAS  Google Scholar 

  12. Patel RN, Singh N, Shukla KK, Chouhan UK, Niclós-Gutiérrez J, Castiñeiras A (2004) J Inorg Biochem 95:231

    Article  Google Scholar 

  13. Bhirud RG, Shrivastava TS (1991) Inorg Chim Acta 179:125

    Article  CAS  Google Scholar 

  14. Liu D, Kwasniewska K (1981) Bull Environ Contan Toxicol 27:289

    Article  CAS  Google Scholar 

  15. Ya D, Svanidze OP, Dolgashova NV, Gogorishvili PV (1974) Zhurnal Neorganicheskoi Khimii 19(12):3304

    Google Scholar 

  16. Proinov I, Schwartz I, Ionescu C, Iliescu T (1967) Farmacia (Bucharest, Romania) 15(2):83

    Google Scholar 

  17. Johnson CK (1976) ORTEP, III Report ORNL- 5138. Oak Ridge National Laboratory, Oak, Ridge TN

    Google Scholar 

  18. Morelock MM, Lood M, Karrkan D, Maleki L, Eichet-Kerger HR, Magesti DJ (1999) J Am Chem Soc 101:4858

    Article  Google Scholar 

  19. Geary WJ (1971) Coord Chem Rev 78:81

    Article  Google Scholar 

  20. Le XY, Tang ML (2002) J Inorg Chem 18:1023

    CAS  Google Scholar 

  21. Jena S, Nath RN, Dash KC (1999) Indian J Chem 38A:350

    CAS  Google Scholar 

  22. Athar F, Arjmand F, Tabassum S (2001) Transition Met Chem 26:426

    Article  CAS  Google Scholar 

  23. Johnson DK, Murphy TB, Rose NJ, Goodwin WH, Pickart L (1982) Inorg Chim Acta 67:159

    Article  CAS  Google Scholar 

  24. Nakamoto K (1970) Infrared and Raman spectra of inorganic and coordination compounds, 2nd edn. Wiley-Interscience, New York

    Google Scholar 

  25. Karayannis MM, Mikulski CM, Pytlewski LL, Labes MM (1974) Inorg Chem 13:1146

    Article  CAS  Google Scholar 

  26. Vansant C, Desseyn HO, Perlepes SP (1995) Transition Met Chem 20:454

    Article  CAS  Google Scholar 

  27. Nakamoto K (1986) Infrared and Raman spectra of inorganic and coordination compounds, 4th edn. Wiley, New York

    Google Scholar 

  28. Lever ABP, Mantovaniand E, Ramaswamy BS (1971) Can J Chem 49:1957

    Article  CAS  Google Scholar 

  29. Chikate RC, Padhye SB (2005) Polyhedron 24:1689

    Article  CAS  Google Scholar 

  30. Kumar A, Kulkarni D, Patil SA, Badami PS (2009) J Sulf Chem 30:145

    Article  Google Scholar 

  31. Parveen S, Arjmand F (2005) Indian J Chem 44A:1151

    CAS  Google Scholar 

  32. Kulkarni A, Avaji PJ, Bagihalli GB, Patil SA, Badami PS (2009) J Coord Chem 62:481

    Article  CAS  Google Scholar 

  33. Bagihalli GB, Avaji PJ, Patil SA, Badami PS (2008) J Coord Chem 43:2639

    CAS  Google Scholar 

  34. Chohan ZH, Suphran CT, Scozzafava A (2004) J Enzyme Inhib Med Chem 79

  35. Patel RN, Gundla VLN, Patel DK (2008) Polyhedron 27:1054

    Article  CAS  Google Scholar 

  36. Frieden E (1975) J Chem Educ 52:754

    Article  CAS  Google Scholar 

  37. Liao Z-R, Zheng X-F, Luo B-S, Shen L-R, Li D-F, Liu H-L, Zhao W (2001) Polyhedron 20:2813

    Article  CAS  Google Scholar 

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Acknowledgments

Our grateful thanks are due to the National Diffraction Facility, X-ray Division, and RSIC (SAIF), IIT, Mumbai, for single crystal data collection. The Head RSIC (SAIF), Central Drug Research Institute, Lucknow, is also thankfully acknowledged for providing analytical and spectral facilities. Financial assistance from UGC [Scheme no. 36-28/2008 (SR) and DRDO] [Scheme no. ERIP/Er 0603574/m/01/1118], Delhi, is also thankfully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, A. P. S. University, Rewa, 486003, Madhya Pradesh, India

    Ram N. Patel, Anurag Singh, Krishna K. Shukla, Dinesh K. Patel & Vishnu P. Sondhiya

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  1. Ram N. Patel
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  2. Anurag Singh
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  3. Krishna K. Shukla
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Correspondence to Ram N. Patel.

Electronic supplementary material

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Appendix A. Supplementary material

Appendix A. Supplementary material

CCDC 766594, 766595 and 766596 contain the supplementary crystallographic data for [Ni(BH)3](NO3)(ClO4)(H2O) 1, [Ni(BH)2(NO3)2] 2 and [Ni(BH)(Tren)](ClO4)2 3 (BH = Benzoylhydrazine, Tren = Tris(2-aminoethyl)amine). These data can be obtained free of charge via http://www.ccdc.cam.ac.uk/conts/retrieving.html, or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax (+44) 1223-336-033; or e-mail: deposit@ccdc.cam.ac.uk.

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Patel, R.N., Singh, A., Shukla, K.K. et al. Synthesis, characterization and biological activity studies of octahedral nickel(II) complexes. Transition Met Chem 36, 179–187 (2011). https://doi.org/10.1007/s11243-010-9451-1

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