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Synthesis, structure, and DNA-binding properties of manganese(II) and zinc(II) complexes with tris(N-methylbenzimidazol-2-ylmethyl)amine ligand

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Abstract

Tris(N-methylbenzimidazol-2-ylmethyl)amine (Mentb) and its two complexes, [Mn(Mentb)(DMF)(H2O)](pic)2 1 and [Zn(Mentb)(pic)](pic) 2 (pic = picrate), have been synthesized and characterized by physico-chemical and spectroscopic methods. Single crystal X-ray diffraction revealed that the two complexes have different structures. In complex 1, the coordination sphere around Mn(II) is distorted octahedral, whereas in complex 2 the coordination sphere around Zn(II) is distorted trigonal bipyramidal. The DNA-binding properties of the free ligand and its two complexes have been investigated by electronic absorption, fluorescence, and viscosity measurements. The results suggest that the ligand and its two complexes bind to DNA via an intercalation binding mode, and their binding affinity for DNA follows the order 1 > 2 > ligand.

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Acknowledgments

The authors acknowledge the financial support and a grant from ‘Qing Lan’ Talent Engineering Funds and Students’ Science and Technology Innovation Funds (grant no. DXS2010-040) by Lanzhou Jiaotong University. The grant from ‘Long Yuan Qing Nian’ of Gansu Province is also acknowledged.

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Authors and Affiliations

  1. School of Chemical and Biological Engineering, Lanzhou Jiaotong University, 730070, Lanzhou, Gansu, China

    Hui-Lu Wu, Ke Li, Tao Sun, Fan Kou, Fei Jia, Jing-Kun Yuan, Bin Liu & Bao-Liang Qi

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  1. Hui-Lu Wu
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  2. Ke Li
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  3. Tao Sun
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  4. Fan Kou
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Correspondence to Hui-Lu Wu.

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Wu, HL., Li, K., Sun, T. et al. Synthesis, structure, and DNA-binding properties of manganese(II) and zinc(II) complexes with tris(N-methylbenzimidazol-2-ylmethyl)amine ligand. Transition Met Chem 36, 21–28 (2011). https://doi.org/10.1007/s11243-010-9429-z

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