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Synthesis, characterization and DNA-binding studies of 1-(pyridin-2-yl)-3-tosylurea and its NdIII, EuIII complexes

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Abstract

1-(Pyridin-2-yl)-3-tosylurea(HL) and its two lanthanide complexes, LnL3 · H2O [Ln = Nd(1), Eu(2)], have been synthesized and characterized on the base of elemental analyses, molar conductivities, IR spectra and thermal analyses. In addition, the DNA-binding properties of the two complexes have been investigated by absorption, fluorescence and viscosity measurements. The experimental results indicated that the complex (1) and (2) can bind to DNA; the binding affinity of the complex (1) is higher than that of complex (2) and the intrinsic binding constants of complex (1) and complex (2) with DNA were 1.24 × 104 m −1 and 8.7 × 103 m −1, respectively. In addition, some factors that influence the fluorescent intensity were also discussed.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China

    Pin-xian Xi, Xiao-hui Liu, Hui-li Lu & Zheng-zhi Zeng

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  1. Pin-xian Xi
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  2. Xiao-hui Liu
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  3. Hui-li Lu
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  4. Zheng-zhi Zeng
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Correspondence to Zheng-zhi Zeng.

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Xi, Px., Liu, Xh., Lu, Hl. et al. Synthesis, characterization and DNA-binding studies of 1-(pyridin-2-yl)-3-tosylurea and its NdIII, EuIII complexes. Transition Met Chem 32, 757–761 (2007). https://doi.org/10.1007/s11243-007-0244-0

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  • DOI: https://doi.org/10.1007/s11243-007-0244-0

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