Abstract
Oral anticoagulants are a mainstay for the prevention and treatment of venous and arterial thrombosis. In 2015, the non-vitamin K oral anticoagulants (NOACs) are already replacing warfarin for many indications. Ongoing studies are focused on development of antidotes and specific reversal agents for the NOACs, and assessing their utility for prevention of cardiovascular events in patients with heart failure, coronary or peripheral artery disease, or embolic stroke of unknown source. This paper (a) lists the current indications for the NOACs; (b) reviews the current impact of the NOACs in each of these indications; (c) outlines future opportunities for the NOACs, and (e) provides perspective on new anticoagulant strategies that may be safer than the NOACs.
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Acknowledgments
Dr. Weitz holds the Canada Research Chair (Tier 1) in Thrombosis and the Heart and Stroke Foundation/J. Fraser Mustard Chair in Cardiovascular Research.
Disclosures
Dr. Weitz is a consultant for, and receives honoraria from Bayer, Boehringer-Ingelheim, Bristol-Myers Squibb, Daiichi-Sankyo, Janssen, Merck, Pfizer, ISIS Pharmaceuticals, and Portola.
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Weitz, J.I. Anticoagulation therapy in 2015: where we are and where we are going. J Thromb Thrombolysis 39, 264–272 (2015). https://doi.org/10.1007/s11239-015-1194-6
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DOI: https://doi.org/10.1007/s11239-015-1194-6