Skip to main content

Advertisement

SpringerLink
Log in

Novel treatments for epistaxis in hereditary hemorrhagic telangiectasia: a systematic review of the clinical experience with thalidomide

  • Letter to the Editor
  • Published:
Journal of Thrombosis and Thrombolysis Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Sharathkumar AA, Shapiro A (2008) Hereditary haemorrhagic telangiectasia. Haemophilia 14:1269–1280

    Article  PubMed  CAS  Google Scholar 

  2. Govani FS, Shovlin CL (2009) Hereditary haemorrhagic telangiectasia: a clinical and scientific review. Eur J Hum Genet 17:860–871

    Article  PubMed  CAS  Google Scholar 

  3. Dupuis-Girod S, Bailly S, Plauchu H (2010) Hereditary hemorrhagic telangiectasia: from molecular biology to patient care. J Thromb Haemost 8:1447–1456

    Article  PubMed  CAS  Google Scholar 

  4. McDonald J, Bayrak-Toydemir P, Pyeritz RE (2011) Hereditary hemorrhagic telangiectasia: an overview of diagnosis, management, and pathogenesis. Genet Med 13:607–616

    Article  PubMed  Google Scholar 

  5. Geisthoff UW, Fiorella ML, Fiorella R (2006) Treatment of recurrent epistaxis in HHT. Curr Pharm Des 12:1237–1242

    Article  PubMed  CAS  Google Scholar 

  6. Jameson JJ, Cave DR (2004) Hormonal and antihormonal therapy for epistaxis in hereditary hemorrhagic telangiectasia. Laryngoscope 114:705–709

    Article  PubMed  Google Scholar 

  7. Sabbà C, Gallitelli M, Palasciano G (2001) Efficacy of unusually high doses of tranexamic acid for the treatment of epistaxis in hereditary hemorrhagic telangiectasia. N Engl J Med 345:926

    Article  PubMed  Google Scholar 

  8. Zarrabeitia R, Albiñana V, Salcedo M, Señaris-Gonzalez B, Fernandez-Forcelledo JL, Botella LM (2010) A review on clinical management and pharmacological therapy on hereditary haemorrhagic telangiectasia (HHT). Curr Vasc Pharmacol 8:473–481

    Article  PubMed  CAS  Google Scholar 

  9. Shovlin CL (2010) Hereditary hemorrhagic telangiectasia: pathophysiology, diagnosis and treatment. Blood Rev 24:203–219

    Article  PubMed  CAS  Google Scholar 

  10. Dupuis-Girod S, Ginon I, Saurin JC et al (2012) Bevacizumab in patients with hereditary hemorrhagic telangiectasia and severe hepatic vascular malformations and high cardiac output. JAMA 307:948–955

    Article  PubMed  CAS  Google Scholar 

  11. Simonds J, Miller F, Mandel J, Davidson TM (2009) The effect of bevacizumab (Avastin) treatment on epistaxis in hereditary hemorrhagic telangiectasia. Laryngoscope 119:988–992

    Article  PubMed  CAS  Google Scholar 

  12. Chen CH, Hsu HH, Hu RH, Lee PH, Ho CM (2012) Long-term therapy with thalidomide in hereditary hemorrhagic telangiectasia: case report and literature review. J Clin Pharmacol 52:1436–1440

    Article  PubMed  CAS  Google Scholar 

  13. Kurstin R (2002) Using thalidomide in a patient with epithelioid leiomyosarcoma and Osler-Weber-Rendu disease. Oncology (Williston Park) 16:21–24

    Google Scholar 

  14. Kersemaekers MAH, Westermann CJJ, Mager JJ, De Weerdt O, Disch FJM, Snijder RJ (2007) Thalidomide for the treatment of epistaxis in hereditary hemorrhagic telangectasia. Hematol Meet Rep 1:22–23

    Google Scholar 

  15. Buscarini E, Manfredi G, Gazzaniga P et al.; on behalf of HHT-NET (2009) Thalidomide for treatment of chronic severe bleeding in hereditary hemorrhagic telangiectasia. Hematol Meet Rep 3:20–21

    Google Scholar 

  16. Gossage JR, Chamberlain SM, Sridhar S, Kumar A (2009) An interim report of thalidomide for treatment of recurrent angioectasia related gastrointestinal bleeding. Hematol Meet Rep 3:21

    Google Scholar 

  17. Lebrin F, Srun S, Raymond K et al (2010) Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nat Med 16:420–428

    Article  PubMed  CAS  Google Scholar 

  18. Penaloza A, Vekemans MC, Lambert C, Hermans C (2011) Deep vein thrombosis induced by thalidomide to control epistaxis secondary to hereditary haemorrhagic telangiectasia. Blood Coagul Fibrinolysis 22:616–618

    Article  PubMed  Google Scholar 

  19. Balduini CL, Pagella F, Bellistri F et al (2012) Efficacy of thalidomide in the treatment of severe recurrent epistaxis in hereditary hemorrhagic telangectasia (HHT): ongoing results of a prospective study. Blood Transfus 10(4):s36

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantua, Italy

    Massimo Franchini, Francesco Frattini, Silvia Crestani & Carlo Bonfanti

Authors
  1. Massimo Franchini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francesco Frattini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Silvia Crestani
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Carlo Bonfanti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Massimo Franchini.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Franchini, M., Frattini, F., Crestani, S. et al. Novel treatments for epistaxis in hereditary hemorrhagic telangiectasia: a systematic review of the clinical experience with thalidomide. J Thromb Thrombolysis 36, 355–357 (2013). https://doi.org/10.1007/s11239-012-0840-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11239-012-0840-5

Keywords

Search

Navigation