Skip to main content

Advertisement

SpringerLink
Log in

Interleukin 8 gene polymorphisms and susceptibility to restenosis after percutaneous coronary intervention

  • Published:
Journal of Thrombosis and Thrombolysis Aims and scope Submit manuscript

Abstract

Interleukin-8 is a strong mediator of inflammation and has been implicated in the biochemical pathways involved in a wide range of inflammatory diseases including atherosclerosis. We investigated the potential influence of two common functional polymorphisms of the interleukin (IL)-8 gene: −251A/T and 781C/T on susceptibility to in stent restenosis (ISR) following percutaneous coronary intervention (PCI). The hypothesis was tested by screening for the prevalence of the above polymorphisms in 201 coronary artery disease (CAD) patients subjected to PCI and presenting with symptoms or signs of recurrent ischemia. Patients were angiographically re-evaluated and formed the ISR group (n = 73) and the non-ISR group (n = 128) based on the presence or absence of ISR. One hundred and forty-seven subjects without angiographic evidence of CAD formed a reference control group (non-CAD group). A borderline statistically significant higher frequency of the TT251TT781 combined genotype was observed in patients with ISR on re-evaluation compared with patients with normal follow-up angiography. The predominance of TT251TT781 was independent of conventional risk factors for cardiovascular disease. Consequently, T251T781 haplotype was significantly more common in the ISR group. The above observations indicate that the genetic diversity of the IL-8 gene influences patient susceptibility to ISR and suggests the implication of IL-8-mediated pathways in the process of ISR. However, the rarity of T251T781 haplotype makes any clinical application of the above observations unfeasible.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Ross R (1999) Atherosclerosis—an inflammatory disease. N Engl J Med 340:115–126. doi:10.1056/NEJM199901143400207

    Article  CAS  PubMed  Google Scholar 

  2. Luster AD (1998) Chemokines—chemotactic cytokines that mediate inflammation. N Engl J Med 338:436–445. doi:10.1056/NEJM199802123380706

    Article  CAS  PubMed  Google Scholar 

  3. Boisvert WA, Curtiss LK, Terkeltaub RA (2000) Interleukin-8 and its receptor CXCR2 in atherosclerosis. Immunol Res 21:129–137. doi:10.1385/IR:21:2-3:129

    Article  CAS  PubMed  Google Scholar 

  4. Apostolakis S, Papadakis EG, Krambovitis E, Spandidos DA (2006) Chemokines in vascular pathology. Int J Mol Med 17:691–701

    CAS  PubMed  Google Scholar 

  5. Hacking D, Knight JC, Rockett K et al (2004) Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease susceptibility. Genes Immun 5:274–282. doi:10.1038/sj.gene.6364067

    Article  CAS  PubMed  Google Scholar 

  6. Ohyauchi M, Imatani A, Yonechi M et al (2005) The polymorphism interleukin 8–251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. Gut 54:330–335. doi:10.1136/gut.2003.033050

    Article  CAS  PubMed  Google Scholar 

  7. Kamali-Sarvestani E, Aliparasti MR, Atefi S (2007) Association of interleukin-8 (IL-8 or CXCL8) −251T/A and CXCR2 +1208C/T gene polymorphisms with breast cancer. Neoplasma 54:484–489

    CAS  PubMed  Google Scholar 

  8. Ben Nasr H, Chahed K, Mestiri S, Bouaouina N, Snoussi K, Chouchane L (2007) Association of IL-8 (−251)T/A polymorphism with susceptibility to and aggressiveness of nasopharyngeal carcinoma. Hum Immunol 68:761–769. doi:10.1016/j.humimm.2007.06.006

    Article  CAS  PubMed  Google Scholar 

  9. Wei YS, Lan Y, Tang RG et al (2007) Single nucleotide polymorphism and haplotype association of the interleukin-8 gene with nasopharyngeal carcinoma. Clin Immunol 125:309–317. doi:10.1016/j.clim.2007.07.010

    Article  CAS  PubMed  Google Scholar 

  10. McCarron SL, Edwards S, Evans PR et al (2002) Influence of cytokine gene polymorphisms on the development of prostate cancer. Cancer Res 62:3369–3372

    CAS  PubMed  Google Scholar 

  11. Vogiatzi K, Apostolakis S, Voudris V, Thomopoulou S, Kochiadakis GE, Spandidos DA (2008) Interleukin 8 and susceptibility to coronary artery disease: a population genetics perspective. J Clin Immunol 28:329–335. doi:10.1007/s10875-008-9194-3

    Article  CAS  PubMed  Google Scholar 

  12. Gaunt TR, Rodríguez S, Day IN (2007) Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool ‘CubeX’. BMC Bioinform 8:428. doi:10.1186/1471-2105-8-428

    Article  Google Scholar 

  13. Hoffmann R, Mintz GS (2000) Coronary in-stent restenosis-predictors, treatment and prevention. Eur Heart J 21:1739–1749. doi:10.1053/euhj.2000.2153

    Article  CAS  PubMed  Google Scholar 

  14. Mitra AK, Agrawal DK (2006) In stent restenosis: bane of the stent era. J Clin Pathol 59:232–239. doi:10.1136/jcp.2005.025742

    Article  CAS  PubMed  Google Scholar 

  15. Third Joint Task Force of European, other Societies on Cardiovascular Disease Prevention in Clinical Practice (2003) European guidelines on cardiovascular disease prevention in clinical practice. Eur J Cardiovasc Prev Rehabil 10:1–78

    Google Scholar 

  16. Petrovic D, Peterlin B (2005) Genetic markers of restenosis after coronary angioplasty and after stent implantation. Med Sci Monit 11:RA127–RA135

    CAS  PubMed  Google Scholar 

  17. Kastrati A, Koch W, Berger PB et al (2000) Protective role against restenosis from an interleukin-1 receptor antagonist gene polymorphism in patients treated with coronary stenting. J Am Coll Cardiol 36:2168–2173. doi:10.1016/S0735-1097(00)01014-7

    Article  CAS  PubMed  Google Scholar 

  18. Humphries S, Bauters C, Meirhaeghe A, Luong L, Bertrand M, Amouyel P (2002) The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis. Eur Heart J 23:721–725. doi:10.1053/euhj.2001.2895

    Article  CAS  PubMed  Google Scholar 

  19. Ferrero V, Ribichini F, Matullo G et al (2003) Estrogen receptor-alpha polymorphisms and angiographic outcome after coronary artery stenting. Arterioscler Thromb Vasc Biol 23:2223–2228. doi:10.1161/01.ATV.0000101181.81022.BF

    Article  CAS  PubMed  Google Scholar 

  20. Shah SH, Hauser ER, Crosslin D et al (2008) ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention. Atherosclerosis (Epub ahead of print)

  21. Oguri M, Kato K, Hibino T et al (2007) Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries. Int J Mol Med 20:533–538

    CAS  PubMed  Google Scholar 

  22. Miranda-Malpica E, Martínez-Rios MA, Fragoso JM et al (2008) The interleukin 1B-511 polymorphism is associated with the risk of developing restenosis after coronary stenting in Mexican patients. Hum Immunol 69:116–121. doi:10.1016/j.humimm.2007.12.003

    Article  CAS  PubMed  Google Scholar 

  23. Caixeta AM, Brito FS Jr, Costa MA, Serrano CV Jr, Petriz JL, Da Luz PL (2007) Enhanced inflammatory response to coronary stenting marks the development of clinically relevant restenosis. Catheter Cardiovasc Interv 69:500–507. doi:10.1002/ccd.21007

    Article  PubMed  Google Scholar 

  24. Qi X, Li S, Li J (2003) The prognostic value of IL-8 for cardiac events and restenosis in patients with coronary heart diseases after percutaneous coronary intervention. Jpn Heart J 44:623–632. doi:10.1536/jhj.44.623

    Article  CAS  PubMed  Google Scholar 

  25. Gogo PB Jr, Schneider DJ, Watkins MW, Terrien EF, Sobel BE, Dauerman HL (2005) Systemic inflammation after drug-eluting stent placement. J Thromb Thrombolysis 19:87–92. doi:10.1007/s11239-005-1378-6

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece

    Konstantina Vogiatzi, Stavros Apostolakis & Demetrios A. Spandidos

  2. Department of Cardiology, Onassis Cardiac Surgery Centre, Athens, Greece

    Vassilis Voudris & Sofia Thomopoulou

  3. Department of Cardiology, University Hospital of Crete, Heraklion, Crete, Greece

    Georgios E. Kochiadakis

Authors
  1. Konstantina Vogiatzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stavros Apostolakis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Vassilis Voudris
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sofia Thomopoulou
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Georgios E. Kochiadakis
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Demetrios A. Spandidos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Demetrios A. Spandidos.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vogiatzi, K., Apostolakis, S., Voudris, V. et al. Interleukin 8 gene polymorphisms and susceptibility to restenosis after percutaneous coronary intervention. J Thromb Thrombolysis 29, 134–140 (2010). https://doi.org/10.1007/s11239-009-0338-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11239-009-0338-y

Keywords

Search

Navigation