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Effects of serum homocysteine and adiponectin levels on platelet aggregation in untreated patients with essential hypertension

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An Erratum to this article was published on 28 August 2009

Abstract

The aim of the present study is to determine and correlate adiponectin, homocysteine, nitric oxide, and ADP-induced platelet aggregation levels in untreated patients with essential hypertension and healthy individuals. A total of 36 individuals, 23 untreated patients with essential hypertension and 13 healthy individuals, were included in the scope of this study. Enzyme-linked immunosorbent assay (ELISA) was used to determine the serum adiponectin and TNF-α levels. The levels of serum homocysteine were measured by using competitive chemiluminescent enzyme immunoassay. Serum concentrations of hsCRP were measured by the Nephelometer. Plasma nitrite, nitrate, and total nitric oxide (NOx) levels were determined by colorimetric method. Homocysteine and hsCRP levels in patients with essential hypertension were found to be significantly higher than those in the control group (P = 0.02, P = 0.001, respectively). The avarage platelet aggregation levels in patient group were higher than control group, but there were no statistically significant differences between them (P > 0.05). In addition, in patients with essential hypertension adiponectin and nitrite levels are significantly lower than control group (P < 0.001, P = 0.045, respectively). We have also found significant correlations between nitrite-platelet aggregation amplitude, nitrite-platelet aggregation slope, nitrite-adiponectin, homocysteine-platelet aggregation amplitude, and sistolic blood pressure-platelet aggregation amplitude levels (r = −0.844; P < 0.001, r = −0.680; P = 0.011, r = 0.454; P = 0.05, r = 0.414; P = 0.05, r = 0.442; P = 0.035, respectively). Increased homocysteine and decreased adiponectin serum levels in patients with essential hypertension correlate well with changes in ADP-induced conventional platelet aggregation. This association may potentially contribute to future thrombus formation and higher risks for cardiovascular events in hypertensive patients.

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Authors and Affiliations

  1. Istanbul Medical Faculty, Bone Marrow Transplantation Unit, Department of Pediatric Haematology and Oncology, Istanbul University, Istanbul, Turkey

    Hakan Ekmekçi & Özlem Balcı Ekmekçi

  2. Seyit Omer Mah. Altimermer cad., Yeni yol sok. Saray Ap. A Blok. No:5/17, 34290, Istanbul, Kocamustafapasa, Turkey

    Hakan Ekmekçi

  3. Cerrahpasa Medical Faculty, Department of Cardiology, Istanbul University, Istanbul, Turkey

    Serap Erdine, Yusup Ataev & Vural Ali Vural

  4. Cerrahpasa Medical Faculty, Department of Biochemistry, Istanbul University, Istanbul, Turkey

    Hüseyin Sönmez, Zeynep Öztürk, İlknur İşler Bütün & Mine Kucur

  5. Cerrahpasa Medical Faculty, Department of Medical Biology, Istanbul University, Istanbul, Turkey

    Çiğdem Gürel & Turgut Ulutin

  6. Cerrahpasa Medical Faculty, Department of Family Medicine, Istanbul University, Istanbul, Turkey

    Nurver Turfaner

  7. Cerrahpasa Medical Faculty, Department of Biostatistics, Istanbul University, Istanbul, Turkey

    Sevim Purisa

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  1. Hakan Ekmekçi
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Correspondence to Hakan Ekmekçi.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s11239-009-0390-7

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Ekmekçi, H., Ekmekçi, Ö.B., Erdine, S. et al. Effects of serum homocysteine and adiponectin levels on platelet aggregation in untreated patients with essential hypertension. J Thromb Thrombolysis 28, 418–424 (2009). https://doi.org/10.1007/s11239-008-0292-0

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  • DOI: https://doi.org/10.1007/s11239-008-0292-0

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