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Use of the TIMI frame count in the assessment of coronary artery blood flow and microvascular function over the past 15 years

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Abstract

Since its introduction, the TIMI frame count method has contributed to the understanding of the pathophysiology of coronary artery disease. In this article, the evolution of the TFC method and its applicability in the assessment of various therapeutic modalities are described.

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Abbreviations

AMI:

Acute myocardial infarction

CCFC:

Coronary clearance frame count

CFR:

Coronary flow reserve

CVR:

Coronary velocity reserve

Cx:

Circumflex artery

CTFC:

Corrected TIMI frame count

ESPRIT:

Enhanced Suppression of the Platelet IIb/IIIa Receptor with Integrilin Therapy

FCR:

Frame count reserve

FCV:

Frame count velocity

FFR:

Fractional flow reserve

IVUS:

Intravascular ultrasound

LAD:

Left anterior descending artery

MLD:

Minimum lumen diameter

PCI:

Percutaneous coronary intervention

PROTECT:

PROTECTion against Post-PCI Microvascular Dysfunction and Post-PCI Ischemia among Anti-Platelet and Anti-Thrombotic Agents

PTCA:

Percutaneous transluminal coronary angioplasty

RCA:

Right coronary artery

RESTORE:

Randomized Efficacy Study of Tirofiban for Outcomes and REstenosis

SPECT:

Single photon emission computed tomography

STEMI:

ST elevation myocardial infarction

SVGs:

Saphenous vein grafts

TFC:

TIMI frame count

TFG:

TIMI flow grade

TIMI:

Thrombolysis In Myocardial Infraction

TMPG:

TIMI myocardial perfusion grade

VAPOR:

VAsodilator Prevention On no-Reflow

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Authors and Affiliations

  1. Cardiovascular Divisions, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Vijayalakshmi Kunadian, Caitlin Harrigan, Cafer Zorkun, Alexandra M. Palmer, Katherine J. Ogando, Leah H. Biller, Erin E. Lord, Scott P. Williams, Michelle E. Lew, Lauren N. Ciaglo, Jacqueline L. Buros, Susan J. Marble, William J. Gibson & C. Michael Gibson

  2. PERFUSE Angiographic Core Laboratory, 350 Longwood Avenue, First Floor, Boston, MA, 02115, USA

    C. Michael Gibson

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  1. Vijayalakshmi Kunadian
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  2. Caitlin Harrigan
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  3. Cafer Zorkun
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Correspondence to C. Michael Gibson.

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Kunadian, V., Harrigan, C., Zorkun, C. et al. Use of the TIMI frame count in the assessment of coronary artery blood flow and microvascular function over the past 15 years. J Thromb Thrombolysis 27, 316–328 (2009). https://doi.org/10.1007/s11239-008-0220-3

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  • DOI: https://doi.org/10.1007/s11239-008-0220-3

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