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Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population

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Abstract

Background Inflammation is one of the major components of atherosclerosis which is the underlying disorder that leads to various diseases including coronary artery disease (CAD). Genes that are involved in the inflammatory processes are therefore good candidates for the risk of CAD. Variations in the genes involved in various molecular pathways of inflammation have been implicated to exaggerated atherosclerosis and the risk of cardiovascular diseases. In this study, we performed a genetic association study on the single nucleotide polymorphisms (SNPs) present in the genes CD14 (−159 C/T), TNFα (−308 G/A), IL-1α (−889 C/T), IL-6 (−174 G/C), PSMA6 (−8 C/G), and PDE4D (SNP83 T/C, respectively) in order to discern their possible role in the susceptibility to CAD in a North Indian population. Methods Angiographically proven CAD patients (n = 210) and age, sex and ethnically matched normal healthy controls (n = 232) were recruited for this case-control study. Genotypes were determined by PCR–RFLP method. Chi-square and logistic regression analyses were performed to compare the genotype and allele frequencies between the patient and the control groups. Results None of the SNPs showed significant association with CAD in the study population before and after adjustment for the confounding risk factors like age, sex, hypertension, smoking habit, and diabetes. Conclusion This study was unable to demonstrate any association between the six gene variants tested and CAD in the North Indian population.

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Acknowledgments

This study was supported by an intramural research funding from the Indian Institute of Technology, Kanpur (IITK). IB was supported by a research studentship from the IITK.

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Authors and Affiliations

  1. Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India

    Indranil Banerjee, Rashmi Parihar, Vijaya Tripathi & Subramaniam Ganesh

  2. LPS Institute of Cardiology, GSVM Medical College, Kanpur, India

    Umeshwar Pandey & Omer M. Hasan

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  1. Indranil Banerjee
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  2. Umeshwar Pandey
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  3. Omer M. Hasan
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  4. Rashmi Parihar
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Correspondence to Subramaniam Ganesh.

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Banerjee, I., Pandey, U., Hasan, O.M. et al. Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population. J Thromb Thrombolysis 27, 88–94 (2009). https://doi.org/10.1007/s11239-007-0184-8

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  • DOI: https://doi.org/10.1007/s11239-007-0184-8

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