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The lack of endothelization after drug-eluting stent implantation as a cause of fatal late stent thrombosis

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Abstract

The authors present a fatal case of late thrombosis of paclitaxel-eluting stent implanted in the left main stem occurring 6 months after the procedure and 3 weeks after the cessation of clopidogrel. An autopsy has shown the lack of endothelization of deployed stent.

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References

  1. Sousa JE, Costa MA, Abizaid AC et al (2001) Sustained supression of neointimal proliferation bz sirolimus-eluting stents. One-year angiographic and intravascular ultrasound follow-up. Circulation 104:2007–2011

    Article  PubMed  CAS  Google Scholar 

  2. Morice MC, Serruys PW, Sousa JE et al (2002) A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med 346:1773–1780

    Article  PubMed  CAS  Google Scholar 

  3. Moses JW, Leon MB, Popma JJ et al, SIRIUS Investigators (2003) Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med 349:1315–1323

    Article  PubMed  CAS  Google Scholar 

  4. Schofer J, Schluter M, Gershlick AH et al, E-SIRIUS Investigators (2003) Sirolimus-eluting stents for treatment of patients with long atherosclerotic lesions in small coronary arteries: double-blind, randomized controlled trial (E-SIRIUS). Lancet 362:1093–1099

    Article  PubMed  CAS  Google Scholar 

  5. Hong MK, Mintz GS, Lee CW et al, Asian Paclitaxel-Eluting Stent Clinical Trial Investigators (2003) Paclitaxel coating reduces in-stent intimal hyperplasia in human coronary arteries: a serial volumetric intravascular ultrasound analysis from the Asian Paclitaxel-Eluting Stent Clinical Trial (ASPECT). Circulation 107:517–520

    Article  PubMed  Google Scholar 

  6. Grube E, Silber S, Hauptmann KE et al (2003) TAXUS I: six- and twelve-month results from a randomized, double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesions. Circulation 107:38–42

    Article  PubMed  CAS  Google Scholar 

  7. Stone GW, Ellis SG, Cox DA et al, TAXUS-IV Investigators (2004) A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. N Engl J Med 350:221–231

    Article  PubMed  CAS  Google Scholar 

  8. Pfisterer ME, Kaiser CA, Bader F et al (2006) Late clinical events related to late stent thrombosis after stopping clopidogrel: prospective randomized comparison between dru-eluting versus bare-metal stenting. Program and abstracts from the American College of Cardiology 55th Annual Scientific Session, March 11–14, 2006, Atlanta, Georgia. Abstract 422–11

  9. Iakovou I, Schnidt T, Bonizzoni E et al (2005) Incidence, predictors and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA 293:2126–2130

    Article  PubMed  CAS  Google Scholar 

  10. Kuchulakanti PK, Chu WW, Torguson R et al (2006) Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus- and paclitaxel-eluting stents. Circulation 113:1108–1113

    Article  PubMed  CAS  Google Scholar 

  11. Takano M, Ohba T, Inami S et al (2006) Angioscopic differences in neointimal overage and in persistence of thrombus between sirolimus-eluting stents and bare metal stents after a 6-month implantation. EHJ 27:2189–2195

    Article  CAS  Google Scholar 

  12. Virmani R, Guagliumi G, Farb A et al (2004) Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious? Circulation 109:701–705

    Article  PubMed  Google Scholar 

  13. Ong A, McFadden E, Regar E et al (2005) Late angiographic stent thrombosis (LAST) events with drug-eluting stents. J Am Coll Cardiol 45:2088–2092

    Article  PubMed  CAS  Google Scholar 

  14. Urban P, Gershlick A, Guagliumi G et al (2006) E-Cypher investigators. Safety of coronary sirolimus-eluting stents in daily clinical practice: one-year follow-up of the e-Cypher registry. Circulation 21:1434–1441

    Article  Google Scholar 

  15. Moreno R, Fernandez C, Hernandez R et al (2005) Drug-eluting stent thrombosis: results from a pooled analysis including 10 randomized studies. J Am Coll Cardiol 45:954–959

    Article  PubMed  CAS  Google Scholar 

  16. Joner M, Finn AV, Farb A et al (2006) Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 48:193–202

    Article  PubMed  Google Scholar 

  17. Laarman GJ, Suttorp MJ, Dirksen MT et al (2006) Paclitaxel-eluting versus uncoated stents in primary percutaneous coronary intervention. N Engl J Med 355:1105–1113

    Article  PubMed  CAS  Google Scholar 

  18. Spaulding C, Henry P, Teiger E et al (2006) Sirolimus-eluting versus uncoated stents in acute myocardial infarction. N Engl J Med 355:1093–1104

    Article  PubMed  CAS  Google Scholar 

  19. Valgimigli M, van Mieghem CAG, Ong ATL et al (2005) Short- and long-term clinical outcome after drug-eluting stent implantation for the percutaneous treatment of left main coronary artery disease. Insights from the rapamycin-eluting and taxus stent evaluated at Rotterdam cardiology hospital registries (RESEARCH and T-SEARCH). Circulation 111:1383–1389

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Cardiology, Masaryk hospital Usti nad Labem, Socialni pece 3316/12A, 401 13, Usti nad Labem, Czech Republic

    Jozef Jakabčin, Marian Bystroň, Radim Špaček, Martin Kvašňak & Pavel Červinka

  2. Department of Cardiology, Faculty hospital Motol, Prague, Czech Republic

    Josef Veselka

  3. Cardio-Vascular Department, Faculty hospital Brno Bohunice, Brno, Czech Republic

    Petr Kala

  4. 2nd Department of Internal Medicine, Faculty hospital, Hradec Kralove, Czech Republic

    Jaroslav Malý

Authors
  1. Jozef Jakabčin
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  2. Marian Bystroň
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  3. Radim Špaček
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  4. Josef Veselka
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  5. Martin Kvašňak
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  6. Petr Kala
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  7. Jaroslav Malý
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  8. Pavel Červinka
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Corresponding authors

Correspondence to Jozef Jakabčin or Pavel Červinka.

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Jakabčin, J., Bystroň, M., Špaček, R. et al. The lack of endothelization after drug-eluting stent implantation as a cause of fatal late stent thrombosis. J Thromb Thrombolysis 26, 154–158 (2008). https://doi.org/10.1007/s11239-007-0080-2

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  • DOI: https://doi.org/10.1007/s11239-007-0080-2

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