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Streptokinase—the drug of choice for thrombolytic therapy

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Abstract

Thrombosis, the blockage of blood vessels with clots, can lead to acute myocardial infarction and ischemic stroke, both leading causes of death. Other than surgical interventions to remove or by pass the blockage, or the generation of collateral vessels to provide a new blood supply, the only treatment available is the administration of thrombolytic agents to dissolve the blood clot. This article describes a comprehensive review of streptokinase (SK). We discuss the biochemistry and molecular biology of SK, describing the mechanism of action, structures, confirmational properties, immunogenecity, chemical modification, and cloning and expression. The production and physico-chemical properties of this SK are also discussed. In this review, considering the properties and characteristics of SK that make it the drug of choice for thrombolytic therapy.

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Acknowledgements

The authors are thankful to Andhra University, Visakhapatnam, India and Council of Scientific & Industrial Research (CSIR), New Delhi, India, for providing financial support and awarding a senior research fellowship (Award No. 9/2 (454)/2k2, EMR.I) to Dr. Adinarayana Kunamneni.

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  1. Adinarayana Kunamneni

    Present address: Department of Biocatalysis, Instituto de Catálisis y Petroleoquímica (CSIC), Lab 305C/ Marie Curie 2, Campus Cantoblanco, 049, Madrid, Spain

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Pharmaceutical Biotechnology Division, Andhra University, Visakhapatnam, 530 003, India

    Adinarayana Kunamneni, Thaer Taleb Abed Abdelghani & Poluri Ellaiah

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  1. Adinarayana Kunamneni
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Kunamneni, A., Abdelghani, T.T.A. & Ellaiah, P. Streptokinase—the drug of choice for thrombolytic therapy. J Thromb Thrombolysis 23, 9–23 (2007). https://doi.org/10.1007/s11239-006-9011-x

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