Abstract
Three-component condensation of 3,5-diamino-1,2,4-triazole with aromatic aldehydes and dimedone in dimethylformamide gives 2-amino-5-aryl-8,8-dimethyl-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[3,2-b]quinazolin-6-ones. The reaction of 3,5-diamino-1,2,4-triazole with dimedone in the absence of aldehyde involves dimethylformamide as one of the carbonyl components to afford 2-amino-8,8-dimethyl-6,7,8,9-tetrahydro[1,2,4]triazolo[2,3-a]quinazolin-6-one.
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Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 115–120.
Original Russian Text Copyright © 2005 by Lipson, Desenko, Borodina, Shirobokova, Musatov.
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Lipson, V.V., Desenko, S.M., Borodina, V.V. et al. Synthesis of Partially Hydrogenated 1,2,4-Triazoloquinazolines by Condensation of 3,5-Diamino-1,2,4-triazole with Aromatic Aldehydes and Dimedone. Russ J Org Chem 41, 114–119 (2005). https://doi.org/10.1007/s11178-005-0131-0
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DOI: https://doi.org/10.1007/s11178-005-0131-0