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Improved Synthesis of Thiofluorescein

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Abstract

Thiofluorescein was synthesized in a preparative yield by successive demethylation of 3,3′-dimethoxydiphenyl sulfide to 3,3′-dihydroxydiphenyl sulfide and condensation of the latter with phthalic anhydride in H2SO4. The title compound was also obtained in a higher yield from 3,3′-dimethoxydiphenyl sulfide directly in a one-pot process combining the condensation in H2SO4 and demethylation in 2 Py · H2SO4.

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Authors and Affiliations

  1. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. Akademika Lavrent’ eva 9, Novosibirsk, 630090, Russia

    V. V. Russkikh, A. V. Konstantinova, V. N. Berezhnaya, T. N. Gerasimova & V. V. Shelkovnikov

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  1. V. V. Russkikh
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  2. A. V. Konstantinova
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  3. V. N. Berezhnaya
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  4. T. N. Gerasimova
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  5. V. V. Shelkovnikov
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__________

Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 60–63.

Original Russian Text Copyright © 2005 by Russkikh, Konstantinova, Berezhnaya, Gerasimova, Shelkovnikov.

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Russkikh, V.V., Konstantinova, A.V., Berezhnaya, V.N. et al. Improved Synthesis of Thiofluorescein. Russ J Org Chem 41, 57–60 (2005). https://doi.org/10.1007/s11178-005-0120-3

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  • DOI: https://doi.org/10.1007/s11178-005-0120-3

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