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Modification of biologically active amides and amines with fluoro-containing heterocycles 5. Fluoro-containing heterocyclic derivatives of 2-amino-1,3,4-thiadiazoles

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Abstract

An approach to modification of biologically active 2-amino-1,3,4-thiadiazoles with fluoro-containing five-membered heterocycles was proposed. The approach involves reactions of imines (generated in situ from 2-amino-1,3,4-thiadiazoles and methyl trifluoropyruvate) with 1,3-binucleophiles such as 6-aminouracils, 6-aminothiouracils, N-substituted 3-aminocyclohexenones, N-substituted ureas, N-substituted benzamidines, and 3-aminocrotononitrile.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi pr., 142432, Chernogolovka, Moscow Region, Russian Federation

    V. B. Sokolov, A. Yu. Aksinenko, T. A. Epishina, T. V. Goreva & I. V. Martynov

Authors
  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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  3. T. A. Epishina
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  4. T. V. Goreva
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  5. I. V. Martynov
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Corresponding author

Correspondence to V. B. Sokolov.

Additional information

For Part 4, see Ref. 1.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 693–697, April, 2011.

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Sokolov, V.B., Aksinenko, A.Y., Epishina, T.A. et al. Modification of biologically active amides and amines with fluoro-containing heterocycles 5. Fluoro-containing heterocyclic derivatives of 2-amino-1,3,4-thiadiazoles. Russ Chem Bull 60, 707–711 (2011). https://doi.org/10.1007/s11172-011-0110-2

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  • DOI: https://doi.org/10.1007/s11172-011-0110-2

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