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One-pot green synthesis and bio-assay of pyrazolylphosphonates

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Abstract

An efficient one-pot synthesis of bioactive pyrazolylphosphonates is accomplished by the reaction of 3-methyl-1-phenyl-2-pyrazoline-5-one with various aryl aldehydes and diethyl phosphite in the presence of β-cyclodextrin (β-CD) as a catalyst. The compounds were tested for their anti-oxidant activity by DPPH and H2O2 radical scavenging assay and for anticancer activity against breast cancer (MCF-7), prostate cancer (DU-145) and lung cancer (A-549) cell lines with sulfarodamine-B (SRB) assay. Most of the synthesized compounds showed promising anti-oxidant activity and significant anticancer activity when compared with the standard drugs.

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Acknowledgements

The authors are grateful to Prof. C. Devendranath Reddy, Department of Chemistry, S.V. University, Tirupati, for his helpful discussions and acknowledge the funding support from DST-SERB, New Delhi, India, through Project No. SB/S1/OC-96/2013, Dt. 05-11-2014. One of the authors Dr. S. Santhisudha expresses sincere thanks to the Science and Engineering Research Board (SERB), New Delhi, India, for providing financial assistance (DST No: PDF/2016/000102, Dt: 11-07-2016). The corresponding author, Prof. C. Suresh Reddy, being an associate member of Institute of Food Security and Sustainable Agriculture, University Malaysia Kelantan, Jeli Campus, Malaysia, expresses his sincere thanks to University Malaysia Kelantan for their timely encouragement in our research work.

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Authors and Affiliations

  1. Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, 517 502, India

    Gundluru Mohan, Sarva Santhisudha, Sudileti Murali, Nemallapudi Bakthavatchala Reddy, Gundala Sravya & Cirandur Suresh Reddy

  2. Department of Chemistry, Dravidian University, Kuppam, Andhra Pradesh, 517 426, India

    Sarva Santhisudha

  3. Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Street, Yekaterinburg, Russian Federation, 620002

    Nemallapudi Bakthavatchala Reddy, Gundala Sravya & Grigory V Zyryanov

  4. I.Ya. Postovskiy Institute of Organic Synthesis, Ural Division of the Russian Academy of Sciences, 22 S. Kovalevskoy Street, Yekaterinburg, Russian Federation, 620219

    Grigory V Zyryanov

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  1. Gundluru Mohan
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  2. Sarva Santhisudha
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Correspondence to Cirandur Suresh Reddy.

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Mohan, G., Santhisudha, S., Murali, S. et al. One-pot green synthesis and bio-assay of pyrazolylphosphonates. Res Chem Intermed 44, 3475–3491 (2018). https://doi.org/10.1007/s11164-018-3319-y

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  • DOI: https://doi.org/10.1007/s11164-018-3319-y

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