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Biosynthesis of gold nanoparticles using Prosopis farcta extract and its in vitro toxicity on colon cancer cells

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Abstract

Gold nanoparticles (Au-NPs) were prepared by “green” synthesis through the aqueous extract of Prosopis farcta. The P. farcta is a special herbal, which it can be a suitable candidate in the reduction process of Au3+ to Au0. The structure and morphology of the synthesized Au-NPs were characterized by UV–visible spectrophotometry, powder X-ray diffraction analysis and high-magnification transmission electron microscopy techniques. The Au-NPs were spherically uniform in shape with particle size of about 25 nm. The cytotoxicity effect of Au-NPs was studied on a colon (HT-29) cancerous cell line via the MTT assay, and the IC50 of Au-NPs was calculated to be 419.7 µg/mL. The results indicated that the apoptotic effects were increased on cells when the Au-NPs concentration reached 200 µg/mL. The Au-NPs were synthesized easily and with a very low cost and time by P. farcta extract for the first time.

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References

  1. W. Chen, W. Cai, L. Zhang, G. Wang, L. Zhang, J. Colloid Interface Sci. 238, 291 (2001)

    Article  CAS  Google Scholar 

  2. B. Knoll, F. Keilmann, Nature 399, 134 (1999)

    Article  CAS  Google Scholar 

  3. S. Sengupta, D. Eavarone, I. Capila, G. Zhao, N. Watson, T. Kiziltepe, R. Sasisekharan, Nature 436, 568 (2005)

    Article  CAS  Google Scholar 

  4. B. Wiley, Y. Sun, Y. Xia, Acc. Chem. Res. 40, 1067 (2007)

    Article  CAS  Google Scholar 

  5. A.D. Dwivedi, K. Gopal, Colloids Surf. A Physicochem. Eng. Asp. 369, 27 (2010)

    Article  CAS  Google Scholar 

  6. M. Khatami, S. Pourseyedi, M. Khatami, H. Hamidi, M. Zaeifi, L. Soltani, Bioresour. Bioprocess. 2, 19 (2015)

    Article  Google Scholar 

  7. A. Miri, N. Dorani, M. Darroudi, M. Sarani, Cell. Mol. Biol. 62, 46 (2016)

    CAS  Google Scholar 

  8. L. Castro, M.L. Blazquez, T.A. Munpz, F. Gonzalez, C. Garcia-Balboa, A. Ballester, Process Biochem. 46, 1076 (2011)

    Article  CAS  Google Scholar 

  9. K.P. Kumar, W. Paul, C.P. Sharma, Process Biochem. 46, 2007 (2011)

    Article  CAS  Google Scholar 

  10. M. Darroudi, M. Sarani, R.K. Oskuee, A.K. Zak, M.S. Amiri, Ceram. Int. 40, 2863 (2014)

    Article  CAS  Google Scholar 

  11. S.P. Dubey, M. Lahtinen, M. Sillanpää, Process Biochem. 45, 1065 (2010)

    Article  CAS  Google Scholar 

  12. F. Namvar, S. Azizi, M.B. Ahmad, K. Shameli, R. Mohamad, M. Mahdavi, PMd Tahir, Res. Chem. Intermed. 41, 5723 (2015)

    Article  CAS  Google Scholar 

  13. F. Harzallah-Skhiri, H. BenJannet, J. Appl. Sci. Res. 1, 130 (2005)

    Google Scholar 

  14. B. Gulalp, O. Karcioglu, Int. J. Clin. Pract. 62, 829 (2008)

    Article  CAS  Google Scholar 

  15. S. Al-Qurán, J. Nat. Prod. 1, 10 (2008)

    Google Scholar 

  16. G. Balasubramani, R. Ramkumar, N. Krishnaveni, A. Pazhanimuthu, T. Natarajan, R. Sowmiya, P. Perumal, J. Trace Elem. Med. Biol. 30, 83 (2015)

    Article  CAS  Google Scholar 

  17. W.H. Chen, X.D. Xu, H.Z. Jia, Q. Lei, G.F. Luo, S.X. Cheng, R.X. Zhuo, X.Z. Zhang, Biomaterials 34, 8798 (2013)

    Article  CAS  Google Scholar 

  18. A.K. Khan, R. Rashid, G. Murtaza, A. Zahra, Trop. J Pharm. Res. 13, 1169 (2014)

    Article  CAS  Google Scholar 

  19. A. Tomar, G. Garg, Global J. Pharm. 7, 34 (2013)

    Google Scholar 

  20. R. Mata, J.R. Nakkala, S.R. Sadras, Colloids Surf. B Biointerfaces 143, 499 (2016)

    Article  CAS  Google Scholar 

  21. J.G. Nirmala, S. Akila, R.T. Narendhirakannan, S. Chatterjee, Adv. Powder Technol. 28, 1170 (2017)

    Article  CAS  Google Scholar 

  22. B.S. Raghavan, S. Kondath, R. Anantanarayanan, R. Rajaram, Process Biochem. 50, 1966 (2015)

    Article  Google Scholar 

  23. T. Muthukumar, B. Sambandam, A. Aravinthan, T.P. Sastrya, J.H. Kimd, Process Biochem. 51, 384 (2016)

    Article  CAS  Google Scholar 

  24. A. Miri, M. Sarani, M.R. Bazaz, M. Darroudi, Spectrochim. Acta A Mol. Biomol. Spectrosc. 141, 287 (2015)

    Article  CAS  Google Scholar 

  25. T. Mosmann, J. Immunol. Methods 65, 55 (1983)

    Article  CAS  Google Scholar 

  26. K.M. Kumar, B.K. Mandal, M. Sinha, V. Krishnakumar, Spectrochim. Acta A Mol. Biomol. Spectrosc. 86, 490 (2012)

    Article  Google Scholar 

  27. F.A.A. Rajathi, C. Parthiban, V.G. Kumar, P. Anantharaman, Spectrochim. Acta A Mol. Biomol. Spectrosc. 99, 166 (2012)

    Article  Google Scholar 

  28. S.A. Aromal, Physica E Low Dimens. Syst. Nanostruct. 44, 1329 (2012)

    Article  CAS  Google Scholar 

  29. T.Y. Suman, S.R. Rajasree, R. Ramkumar, C. Rajthilak, P. Perumal, Spectrochim. Acta A Mol. Biomol. Spectrosc. 118, 11 (2014)

    Article  CAS  Google Scholar 

  30. M.F. Zayed, W.H. Eisa, Spectrochim. Acta A Mol. Biomol. Spectrosc. 121, 238 (2014)

    Article  CAS  Google Scholar 

  31. S.A. Aromal, K.V.D. Babu, D. Philip, Spectrochim. Acta A Mol. Biomol. Spectrosc. 96, 1025 (2012)

    Article  Google Scholar 

  32. P. Balashanmugam, P. Durai, M.D. Balakumaran, P.T. Kalaichelvan, J. Photochem. Photobiol. B 165, 163 (2016)

    Article  CAS  Google Scholar 

  33. M.Y. Lan, Y.B. Hsu, C.H. Hsu, C.Y. Ho, J.C. Lin, S.W. Lee, Auris Nasus Larynx 40, 563 (2013)

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacognosy, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran

    Abdolhossien Miri

  2. Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Majid Darroudi

  3. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Zabol University of Medical Science, Zabol, Iran

    Reza Entezari

  4. Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, P.O. Box 3333-669699, Zabol, Iran

    Mina Sarani

Authors
  1. Abdolhossien Miri
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  2. Majid Darroudi
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  3. Reza Entezari
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  4. Mina Sarani
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Correspondence to Mina Sarani.

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Miri, A., Darroudi, M., Entezari, R. et al. Biosynthesis of gold nanoparticles using Prosopis farcta extract and its in vitro toxicity on colon cancer cells. Res Chem Intermed 44, 3169–3177 (2018). https://doi.org/10.1007/s11164-018-3299-y

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  • DOI: https://doi.org/10.1007/s11164-018-3299-y

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