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Copper(I)-catalyzed synthesis of thienopyrazoloquinazolinone derivatives under ligand-free conditions

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Abstract

A series of fused tetracyclic thieno[3′,2′:3,4]pyrazolo[5,1-b]quinazolin-6(4H)-one derivatives were synthesized by reaction of 2-aminobenzohydrazide and 3-bromothiophene-2-carbaldehyde in good yields. The reaction includes subsequent condensation, cyclization, and CuBr-catalyzed Ullmann-type reaction under ligand-free conditions.

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Acknowledgments

We are grateful to the National Natural Science Foundation of China (20802061), the Major Natural Science Foundation of Jiangsu Province (14KJA150004), and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions for financial support.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou, 221116, Jiangsu, People’s Republic of China

    Wen-Ting Zhang, Dong-Sheng Chen, Mei-Mei Zhang & Xiang-Shan Wang

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  1. Wen-Ting Zhang
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  2. Dong-Sheng Chen
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  3. Mei-Mei Zhang
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  4. Xiang-Shan Wang
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Correspondence to Xiang-Shan Wang.

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Zhang, WT., Chen, DS., Zhang, MM. et al. Copper(I)-catalyzed synthesis of thienopyrazoloquinazolinone derivatives under ligand-free conditions. Res Chem Intermed 42, 6769–6776 (2016). https://doi.org/10.1007/s11164-016-2497-8

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