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Microwave-assisted synthesis of novel pyrazole and pyrazolo[3,4-d]pyridazine derivatives incorporating diaryl sulfone moiety as potential antimicrobial agents

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Abstract

We present a novel, facile and efficient methodology for the synthesis of pyrazoles and pyrazolo[3,4-d]pyridazines linked to diaryl sulfone moiety using synthetic talc as a solid base catalyst under microwave irradiation, via 1,3-dipolar cycloaddition reaction of the E-3-(dimethylamino)-1-(4-(phenylsulfonyl)phenyl)prop-2-en-1-one with different hydrazonyl halides. All synthesized compounds were evaluated for antibacterial and antifungal activities. The results showed that most of the synthesized compounds exhibited promising antimicrobial activities.

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Authors and Affiliations

  1. Department of Green Chemistry, National Research Centre, 33 EL Bohouth St. (former El Tahrir St.), Dokki, Giza, 12622, Egypt

    Mohamed F. Mady, Tamer S. Saleh, Ahmed A. El-Kateb & Naglaa M. Abd El-Rahman

  2. Microbiology and Immunology Department and Center of Excellence for Advanced Sciences, National Research Centre, 33 EL Bohouth St. (former El Tahrir St.), Dokki, Giza, 12622, Egypt

    Sherein I. Abd El-Moez

Authors
  1. Mohamed F. Mady
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  2. Tamer S. Saleh
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  3. Ahmed A. El-Kateb
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  4. Naglaa M. Abd El-Rahman
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  5. Sherein I. Abd El-Moez
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Correspondence to Mohamed F. Mady.

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Mady, M.F., Saleh, T.S., El-Kateb, A.A. et al. Microwave-assisted synthesis of novel pyrazole and pyrazolo[3,4-d]pyridazine derivatives incorporating diaryl sulfone moiety as potential antimicrobial agents. Res Chem Intermed 42, 753–769 (2016). https://doi.org/10.1007/s11164-015-2054-x

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