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A facile and efficient synthesis of tetrahydrobenzo[b]pyrans using lactose as a green catalyst

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Abstract

Lactose has been used as a mild, efficient, green, and inexpensive catalyst for the synthesis of tetrahydrobenzo[b]pyran derivatives via a one-pot, three-component condensation between aryl aldehydes, malononitrile, and dimedone in H2O:EtOH at 60 °C. This method offers a considerable number of advantages including short reaction time, high to quantitative yields, low cost, easy accesses, and simple work-up.

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Acknowledgments

We are thankful to the University of Sistan and Baluchestan Research Council for the partial support of this research.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran

    Fatemeh Noori Sadeh, Malek Taher Maghsoodlou, Nourallah Hazeri & Mehrnoosh Kangani

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  1. Fatemeh Noori Sadeh
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  2. Malek Taher Maghsoodlou
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  3. Nourallah Hazeri
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  4. Mehrnoosh Kangani
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Correspondence to Malek Taher Maghsoodlou.

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Sadeh, F.N., Maghsoodlou, M.T., Hazeri, N. et al. A facile and efficient synthesis of tetrahydrobenzo[b]pyrans using lactose as a green catalyst. Res Chem Intermed 41, 5907–5914 (2015). https://doi.org/10.1007/s11164-014-1710-x

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  • DOI: https://doi.org/10.1007/s11164-014-1710-x

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